{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:34Z","timestamp":1787013814076,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T00:00:00Z","timestamp":1516665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2018,10]]},"abstract":"\n Background and aims<\/jats:title>\n \n The aim of this study was to investigate the effectiveness of a levonorgestrel\u2010releasing intrauterine device (\n LNG<\/jats:styled-content>\n \u2010\n IUS<\/jats:styled-content>\n ) in the symptomatic relief of pain in women with endometriosis and additionally, to assess the changes in women's life quality and serum cancer antigen (\n CA)<\/jats:styled-content>\n 125 levels.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and methods<\/jats:title>\n \n All women who had an\n LNG<\/jats:styled-content>\n \u2010\n IUS<\/jats:styled-content>\n inserted for the treatment of dysmenorrhea, chronic pelvic pain or both for more than six months over a two\u2010year period were included in the study. Each woman was asked to complete questionnaires of the Short Form\u201036 and visual analogue scales (\n VAS<\/jats:styled-content>\n ) in the first visit and the third, sixth, ninth and twelfth months after the\n LNG<\/jats:styled-content>\n \u2010\n IUS<\/jats:styled-content>\n insertion.\n CA<\/jats:styled-content>\n 125 levels were measured at each visit.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Forty\u2010five women were included in the study. At the end of 12\u00a0months, mean dysmenorrhoea\n VAS<\/jats:styled-content>\n score decreased from 6.13 to 2.88, mean dsyspareunia\n VAS<\/jats:styled-content>\n score from 6.04 to 2.61 and\n CA<\/jats:styled-content>\n 125 level from 50.67 to 22.45. Endometriomas reduced in size in six women (mean size decreased from 31 to 20\u00a0mm) and disappeared in three.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Several favourable outcomes were found following\n LNG<\/jats:styled-content>\n \u2010\n IUS<\/jats:styled-content>\n insertion: (i) dyspareunia and dysmenorrhoea were clearly reduced; (ii) the size of endometriomas were decreased; (iii)\n CA<\/jats:styled-content>\n 125 levels significantly decreased; (iv) a few women experienced the typical systemic adverse effects of progestogens; however,\n LNG<\/jats:styled-content>\n \u2010\n IUS<\/jats:styled-content>\n \u2010related adverse events were generally tolerable and the discontinuation rate was as low as 6.66% (3\/45).\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ajo.12773","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T03:22:41Z","timestamp":1516677761000},"page":"560-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The levonorgestrel\u2010releasing intrauterine system is associated with a reduction in dysmenorrhoea and dyspareunia, a decrease in\n CA<\/scp>\n 125 levels, and an increase in quality of life in women with suspected endometriosis"],"prefix":"10.1111","volume":"58","author":[{"given":"Nese","family":"Yucel","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Goztepe Training and Research Hospital Istanbul Medeniyet University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdem","family":"Baskent","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Goztepe Training and Research 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