{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:23:01Z","timestamp":1762867381743,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pre\u2010labour rupture of membranes (<jats:styled-content style=\"fixed-case\">PROM<\/jats:styled-content>) at term is a common event with early induction of labour reducing infectious morbidity without increasing the caesarean rate. Syntocinon is commonly used for induction but prostaglandins are also routinely used. Large studies have shown no difference in the maternal and neonatal outcomes with either method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the safety and efficacy of vaginal prostaglandin (<jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>) compared to syntocinon for induction of labour in term\u2010<jats:styled-content style=\"fixed-case\">PROM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a single\u2010centre randomised controlled trial at Ipswich Hospital of women presenting at \u226537\u00a0weeks gestation with <jats:styled-content style=\"fixed-case\">PROM<\/jats:styled-content>. Women were randomised and managed in labour as per local guidelines. Analysis was by intention to treat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and eighty\u2010four women were recruited, 90 in the <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> group and 94 in the oxytocin group. Women in both arms were of similar demographics and 53% of women in the <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> group did not require any oxytocin. There was a statistically significant lower incidence of fetal heart rate abnormality in the <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> group, 4.4% versus 12.8%. There was no difference in epidural use, caesarean section, maternal infection, admission to special care nursery or neonatal sepsis. Time to onset of labour was significantly longer in the PG group, 25.7\u00a0h versus 19.7\u00a0h but with no difference in the length of first stage. Maternal satisfaction was high in both groups with no significant difference in breastfeeding rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Induction of labour with oxytocin or vaginal prostaglandins are safe and efficacious options for women in the context of <jats:styled-content style=\"fixed-case\">PROM<\/jats:styled-content> at term.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12788","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T06:06:37Z","timestamp":1519279597000},"page":"654-659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prostaglandin gel versus oxytocin \u2013 prelabour rupture of membranes at term \u2013 A randomised controlled trial"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5979-8091","authenticated-orcid":false,"given":"Kassam","family":"Mahomed","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Ipswich Hospital and University of Queensland  Ipswich Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kellie","family":"Wild","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Ipswich Hospital  Ipswich Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R.","family":"Weekes","sequence":"additional","affiliation":[{"name":"Caboolture Hospital  Caboolture Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"CD005302","article-title":"Planned early birth versus expectant management (waiting) for prelabour rupture of membranes at term (37\u00a0weeks or more)","author":"Middleton P","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2010.01206.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604183341601"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.04.031"},{"issue":"3","key":"e_1_2_6_6_1","first-page":"199","article-title":"A randomized study comparing intravaginal prostaglandin gel (PGE2) with oxytocin for induction of labour in premature rupture of membrane at term","volume":"14","author":"Rijal H","year":"2012","journal-title":"Nepal Med Coll J"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.07.035"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1028-4559(10)60010-1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(15)30290-5"},{"key":"e_1_2_6_10_1","unstructured":"NICE.Inducing labour. 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