{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:09:51Z","timestamp":1758816591856,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>For Australian women with screen\u2010detected adenocarcinoma<jats:italic>\u2010in\u2010situ<\/jats:italic> (<jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content>), an excisional biopsy is mandatory for further assessment, treatment, and to exclude the presence of cervical adenocarcinoma. The only exclusion to this rule is if the woman has a clinically evident invasive cervical malignancy. Excisional treatments should be tailored according to a patient's age and future obstetric needs. To date, practitioner compliance with this recommendation has not been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate clinical management for patients with a cytological test result predicting <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content>. Secondary aims were to report the most severe histological findings of excisional biopsy specimens following cytological prediction of <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content> and investigate treatment outcomes for conservatively managed patients with biopsy\u2010confirmed <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A retrospective, population\u2010based cohort study was conducted. Cases were ascertained from the Tasmanian and Western Australia Cervical Screening Registries. Cytology and histology results for women with an index cervical smear reporting <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content> from 2001 to 2012 were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred and twenty\u2010one women (age range 18\u201369\u00a0years) had an index smear reporting <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content>. Cervical cancer was diagnosed in 62 (19.3%) patients within the study cohort. Twenty\u2010one of 321 patients (6.7%) were not initially managed according to the 2005 <jats:styled-content style=\"fixed-case\">NHMRC <\/jats:styled-content><jats:italic>Guidelines for the management of asymptomatic women with screen\u2010detected abnormalities,<\/jats:italic> including two women diagnosed with an occult cancer following a total hysterectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A minority of women were not managed in accordance with guidelines. This is of concern given that nearly one in five women with a smear predicting <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content> had a final diagnosis of cervical cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12886","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T21:12:55Z","timestamp":1538773975000},"page":"294-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["RANZCOG Fellows\u2019 adherence to guidelines following cytological prediction of cervical adenocarcinoma\u2010<i>in\u2010situ<\/i>: Cause for concern?"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0728-1584","authenticated-orcid":false,"given":"Aime","family":"Powell","sequence":"first","affiliation":[{"name":"Institute for Health Research University of Notre Dame Australia  Fremantle Western Australia Australia"},{"name":"Gynaecological Cancer Research 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