{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:47:14Z","timestamp":1770706034094,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Germline <jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content>1\/2 mutations account for approximately 15% of invasive ovarian carcinomas. Referral of all women with non\u2010mucinous epithelial tubo\u2010ovarian and peritoneal cancer, especially high\u2010grade serous carcinoma (<jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content>) to genetic services for genetic counselling and subsequent <jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content> testing, has become standard of care in many countries. Publicly funded <jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content> testing was restricted to women \u226470 years old with <jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content> in New Zealand for most of our study period. Referral rates of women with <jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content> mutation testing in New Zealand have not previously been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine the proportion of eligible patients with tubo\u2010ovarian or peritoneal <jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content> referred to Auckland Gynaecologic Oncology Centre who were referred for genetic counselling. To determine the number of patients who underwent <jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content>1\/2 genetic testing and the rate of germline <jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content> mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible cases were identified from Auckland Gynaecologic Oncology multidisciplinary meetings database from 1 January 2012 to 31 December 2014. Genetic referrals sent were checked against the genetic services database to ensure that referrals were received. Genetic counselling clinic attendance, uptake and results of genetic testing were also collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and four eligible patients were identified with 58 patients referred. Referral rates increased from 37.5% in 2012 to 64.3% in 2014. Of the 58 patients referred, 53 attended genetic counselling, and 49 underwent <jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content> mutation testing, of whom 10 (20.4%) tested positive for a germline <jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content> mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, 55.8% of eligible patients were referred for genetic testing; however, referral rates increased with time. This <jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content> mutation\u2010positive rate is comparable with current international data.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12964","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T05:51:03Z","timestamp":1552974663000},"page":"444-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Referral patterns for genetic counselling of women diagnosed with tubo\u2010ovarian or peritoneal high\u2010grade serous carcinoma (<scp>HGSC<\/scp>) within the Auckland Gynaecological Oncology Centre"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7112-3329","authenticated-orcid":false,"given":"Michael J","family":"Burling","sequence":"first","affiliation":[{"name":"Westmead Public Hospital, Gynaeoncology Unit  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Gamet","sequence":"additional","affiliation":[{"name":"Auckland City Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lois","family":"Eva","sequence":"additional","affiliation":[{"name":"Auckland City Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai Ling","family":"Tan","sequence":"additional","affiliation":[{"name":"Auckland City Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World cancer research fund international.Cancer facts and figures. 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