{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:18:04Z","timestamp":1772817484654,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>While intracytoplasmic sperm injection (<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>) was developed for overcoming male infertility, it is increasingly being used for non\u2010male factor indications, without consensus regarding the safety and efficacy of this approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine whether ICSI offers any benefit compared to standard <jats:italic>in vitro<\/jats:italic> fertilisation (<jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>), in the setting of normal semen parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Retrospective analysis of reproductive outcomes in 3363 stimulated cycles (<jats:styled-content style=\"fixed-case\">IVF <\/jats:styled-content>= 1661; <jats:styled-content style=\"fixed-case\">ICSI <\/jats:styled-content>= 1702), in patients treated between 2009\u20132015, was performed. Selected couples had no male factor infertility. Couples with abnormal semen parameters (based on <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> 2010 guidelines), presence of anti\u2010sperm antibodies and low oocyte yield of \u22644 oocytes, were excluded. The outcomes analysed included: (1) fertilisation rate (<jats:styled-content style=\"fixed-case\">FR<\/jats:styled-content>); (2) clinical pregnancy rate (<jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content>); and (3) live birth rate (<jats:styled-content style=\"fixed-case\">LBR<\/jats:styled-content>), by method of fertilisation used (<jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> vs <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>) and controlling for significant confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FR<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CPR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LBR<\/jats:styled-content> were significantly higher in the <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> group compared with <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> (67.1% vs 62.3%, 23.06% vs 16.8%, 17.22% vs 13.2%, respectively). Pregnancy rate with <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> was approximately 30% lower than with <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>, even when controlling for significant factors such as day of embryo transfer and number of embryos transferred. This translates to one less pregnancy in every 15 cycles where <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> was used without clear indication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data suggest that <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> may be detrimental to clinical outcomes and contributes to the wider understanding of use of <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> in normospermic men.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13004","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T06:00:06Z","timestamp":1560319206000},"page":"706-711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Use of intracytoplasmic sperm injection (<scp>ICSI<\/scp>) in normospermic men may result in lower clinical pregnancy and live birth 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