{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T13:54:23Z","timestamp":1776952463597,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the effect of oral complementary and alternative medicine (CAM) on the oocyte, embryo and pregnancy rate in first\u2010cycle <jats:italic>in vitro<\/jats:italic> fertilisation (<jats:styled-content style=\"fixed-case\">IVF)<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A prospective cohort study using the International <jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content> Questionnaire, reviewing patient <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> outcomes. Local ethics approval was obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over 18\u00a0months (October 2015 to April 2017) 25 patients were prospectively recruited, with 52% (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>13) using herbal or dietary supplements, including Chinese medicine, fish oil, liver \u2018detox\u2019, co\u2010enzyme Q10, spirulina, probiotics and maca root. Comparing users to non\u2010users, there was no statistical difference in age, body mass index, primary infertility, gravidity or parity. Total follicle\u2010stimulating hormone dose was equivalent (2760 vs 2451 <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>,<jats:italic> P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.60), but there was a significant difference in maximum oestradiol response (4134 vs 8335, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.045), on univariate analysis alone. While no difference was found in the number of follicles &gt;11 mm (7.5 vs 11.5, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.80), or eggs collected (8.0 vs 12.5, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.91), there was a lower number of eggs fertilised in users (3.0 vs 4.0, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.046). There was no difference in the chemical or clinical pregnancy rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This small study demonstrates a high use of oral CAM in first\u2010cycle <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> patients, with a wide range of types. There appears to be a lower fertilisation rate in the women who used oral\u00a0CAMs. It is unclear whether this is a negative effect of the CAM or selection bias. This concern about confounders supports the need for further research into unregulated herbal medicine on <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> outcomes, given that so many women are using these substances.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13023","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T02:26:55Z","timestamp":1562812015000},"page":"712-716","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral complementary medicine use and first\u2010cycle <i>in vitro<\/i> fertilisation \u2013 What are the effects on the oocyte, the embryo and the pregnancy rate?"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3934-732X","authenticated-orcid":false,"given":"Violet","family":"Kieu","sequence":"first","affiliation":[{"name":"Women's and Newborn Program Monash Health Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2832-4747","authenticated-orcid":false,"given":"Martin","family":"Healey","sequence":"additional","affiliation":[{"name":"The Royal Women's Hospital Melbourne Victoria Australia"},{"name":"Department of Obstetrics &amp; Gynaecology The University of Melbourne Melbourne Victoria Australia"},{"name":"Monash IVF Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8756-3994","authenticated-orcid":false,"given":"Beverley","family":"Vollenhoven","sequence":"additional","affiliation":[{"name":"Women's and Newborn Program Monash Health Melbourne Victoria Australia"},{"name":"Monash IVF Clayton Victoria Australia"},{"name":"Department of Obstetrics &amp; Gynaecology Monash University Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12056"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12324"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep077"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12365"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep17475"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja16.00614"},{"key":"e_1_2_6_8_1","first-page":"1","article-title":"Promoting healthy lifestyle in fertility clinics; 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