{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:36:08Z","timestamp":1747182968213,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T00:00:00Z","timestamp":1577404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Chlamydia trachomatis <\/jats:italic>(<jats:italic>C.\u00a0trachomatis<\/jats:italic>) prevalence has been reported to be increasing. Whether this is a true increase over time or confounded by increases in testing and\/or use of more sensitive assays is to be determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>One laboratory service has been detecting <jats:italic>C.\u00a0trachomatis<\/jats:italic> for the past 30\u00a0years within the Royal Women's Hospital Melbourne. We conducted a retrospective audit of records over the period 1986\u20132016 from a clinic population routinely offered chlamydia screening. These were women presenting for family planning advice (termination of pregnancy, intrauterine device insertion or considered at high risk), who underwent chlamydia testing in the context of various diagnostic assays used over this time period. Assays utilised included culture, enzyme immunoassay (EIA), DNA probe, and nucleic acid amplification testing (NAAT). Non\u2010parametric test for trend was used to determine significant differences between prevalence estimates across ordered groups. Least squares regression was conducted to describe a linear trend matching known data points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, there was no significant change for chlamydia prevalence which was 2.2%, in the 30\u2010year study period (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.7). Over time diagnostic assays changed from culture, to EIA, DNA probe, to the more sensitive NAAT. The bulk of the positives were in women under 25\u00a0years of age (57%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chlamydia prevalence has been stable over 30\u00a0years, remaining a problem in young women. Screening for those at risk needs underscoring in a national sexual health program.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13106","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T18:34:26Z","timestamp":1577471666000},"page":"149-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010term trends of <i>Chlamydia trachomatis<\/i> in a clinic population at the Royal Women's Hospital, Melbourne"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6869-311X","authenticated-orcid":false,"given":"Suzanne Marie","family":"Garland","sequence":"first","affiliation":[{"name":"Centre for Women's Infectious Diseases Research The Royal Women's Hospital Melbourne Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology Royal Women's Hospital University of Melbourne Melbourne Victoria Australia"},{"name":"Infection &amp; Immunity Theme 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