{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:36:11Z","timestamp":1747182971277,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cervical screening programs have had an important effect on the reduction of cervical cancer rates. Comprehensive programs require access to pathological review to improve the sensitivity of screening cytology and the specificity of diagnostic histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine the number of cases where cervical cytology or histology was amended at cytopathological review; whether amendments were \u2018upgrades\u2019 or \u2018downgrades\u2019, and how amendments aligned with follow\u2010up results for these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A retrospective cohort study was performed of all patients reviewed from January 2016 to December 2017 (<jats:italic>n<\/jats:italic>\u00a0=\u00a0287 cases, from 254 patients) at colposcopy multidisciplinary meetings at Wellington Hospital, a tertiary referral hospital. Where amendments to cytology or histology were made, follow\u2010up results were retrieved where available (85.7% and 84.2% respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cytology or histology was amended in 24.7% of cases. Smear cytology was amended in 16.7%. Where cytology was upgraded (<jats:italic>n<\/jats:italic>\u00a0=\u00a09), 44% had subsequent results of equal or higher grade including one case of adenocarcinoma. Where cytology was downgraded (<jats:italic>n<\/jats:italic>\u00a0=\u00a019), 93.8% (81.9\u2013100%) had follow\u2010up studies showing equal or lower results. Cervical biopsy histology was amended in 12.2% of cases (upgraded <jats:italic>n<\/jats:italic>\u00a0=\u00a019, downgraded <jats:italic>n<\/jats:italic>\u00a0=\u00a06). Large loop excision of the transformation zone or cone biopsy histology was amended in three cases (7.9%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cytopathological review appears to improve the specificity of the comprehensive cervical screening program, leading to a reduction in unnecessary treatment. Additionally, a small number of cases of malignant or premalignant disease were detected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13136","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T10:00:35Z","timestamp":1582279235000},"page":"444-448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cytopathological review of cervical pathology: Impact for women and follow\u2010up results"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4572-0277","authenticated-orcid":false,"given":"Simon M.","family":"Scheck","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Hawke\u2019s Bay Fallen Soldiers\u2019 Memorial Hospital Hastings New Zealand"},{"name":"Department of Obstetrics and Gynaecology School of Medicine Wellington Regional Hospital University of Otago Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam J.","family":"Lepine","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology School of Medicine Wellington Regional Hospital University of Otago Wellington New Zealand"},{"name":"Department of Obstetrics and Gynaecology Wellington Regional Hospital Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Wellington Regional Hospital Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Robb","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Wellington Regional Hospital Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Southern Community Laboratories Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Clentworth","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Wellington Regional Hospital Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dushyant","family":"Maharaj","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology School of Medicine Wellington Regional Hospital University of Otago Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Tully","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Wellington Regional Hospital Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Tristram","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Wellington Regional Hospital Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,21]]},"reference":[{"volume-title":"Guidelines for Cervical Screening in New Zealand","year":"2008","author":"National Screening Unit","key":"e_1_2_6_2_1"},{"issue":"20","key":"e_1_2_6_3_1","article-title":"Cervical screening programme colposcopy and programme Management","author":"Tidy JA","year":"2016","journal-title":"Public Health Engl"},{"key":"e_1_2_6_4_1","unstructured":"HPVprimary screening.National Screening Unit New Zealand 2017."},{"key":"e_1_2_6_5_1","unstructured":"AndersonL SavilleM WrightG.Cytology and explanation of AMBS 2004 terminology for reporting cervical cytology 2018."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.11.1500"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02651.x"},{"key":"e_1_2_6_8_1","unstructured":"Cancer Council Australia Cervical Cancer Screening Guidelines 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