{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:36:13Z","timestamp":1747182973604,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T00:00:00Z","timestamp":1586822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>How best to target intrapartum antibiotic prophylaxis (IAP) to minimise both Early\u2010Onset Group B Streptococcus (EOGBS) neonatal infection and maternal\/fetal antibiotic exposure is uncertain, with both routine\u2010screening and risk\u2010factor approaches available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This retrospective cohort study was undertaken to examine the outcomes of a hybrid risk\u2010and\u2010screen approach to EOGBS prevention using GBS polymerase chain reaction (PCR). The target population was women with term prelabour rupture of membranes (TermPROM) having the risk factor of prolonged rupture of membranes (ROM) \u226518\u00a0h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Non\u2010labouring TermPROM women had rapid GBS PCR testing at presentation. GBS screen\u2010positive women proceeded to induction of labour and received IAP. GBS screen\u2010negative women were allowed home to await spontaneous labour and not given IAP regardless of duration of ROM, unless other risk factors developed. For all other women, the risk\u2010factor approach was followed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2009 to 2018, there were 20 cases of culture\u2010positive EOGBS, a rate of 0.36\/1000 live births (95% CI 0.22\u20130.56\/1000), comparable to other recent reports. Over 2010\u20132018 when laboratory data were available, 1120 TermPROM women with ROM \u226518\u00a0h avoided antibiotics because they were GBS PCR\u2010negative (2.3% of all births, 3.6% of vaginal births) while 338 TermPROM women with ROM &lt;18\u00a0h received targeted antibiotics for being GBS\u2010positive. No cases of EOGBS occurred in TermPROM women, those with ROM \u226518\u00a0h, or due to protocol\u2010compliance failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A hybrid approach involving risk\u2010factor\u2010based IAP and intrapartum GBS PCR screening of non\u2010labouring TermPROM women delivers acceptably low rates of EOGBS while minimising and better targeting antibiotic exposure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13159","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T05:05:19Z","timestamp":1586927119000},"page":"753-759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preventing Early\u2010Onset Group B Streptococcus neonatal infection and reducing antibiotic exposure using a rapid PCR test in term prelabour rupture of membranes"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6509-6926","authenticated-orcid":false,"given":"Mandy","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Women's and Newborn Health Westmead Hospital Sydney New South Wales Australia"},{"name":"Faculty of Medicine University of Sydney Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin","family":"Keighley","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Sydney Sydney New South Wales Australia"},{"name":"Centre for Infectious Diseases and Microbiology Public Health Institute for Clinical Pathology and Medical Research\u2010New South Wales Health Pathology Westmead Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Watts","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Sydney Sydney New South Wales Australia"},{"name":"Centre for Infectious Diseases and Microbiology Public Health Institute for Clinical Pathology and Medical Research\u2010New South Wales Health Pathology Westmead Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Plymoth","sequence":"additional","affiliation":[{"name":"Pite\u00e5 Hospital Pite\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therese M.","family":"McGee","sequence":"additional","affiliation":[{"name":"Department of Women's and Newborn Health Westmead Hospital Sydney New South Wales Australia"},{"name":"Faculty of Medicine University of Sydney Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2017-314671"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix658"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12145"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12977"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix655"},{"key":"e_1_2_6_7_1","unstructured":"Maternal Group B Streptococcus in pregnancy: screening and management. 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