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Little is understood about its effects during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To describe the current understanding of COVID\u201019 illness in pregnant women, to describe obstetric outcomes and to identify gaps in the existing knowledge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medline Ovid, EMBASE, World Health Organization COVID\u201019 research database and Cochrane COVID\u201019 in pregnancy spreadsheet were accessed on 18\/4, 18\/5 and 23\/5 2020. Articles were screened via Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses guidelines. The following were excluded: reviews, opinion pieces, guidelines, articles pertaining solely to other viruses, single case reports.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty articles were included in this review. Some pregnant participants may have been included in multiple publications, as admission dates overlap for reports from the same hospital. However, a total of 1287 confirmed SARS\u2010CoV\u20102 positive pregnant cases are reported. Where universal testing was undertaken, asymptomatic infection occurred in 43.5\u201392% of cases. In the cohort studies, severe and critical COVID\u201019 illness rates approximated those of the non\u2010pregnant population. Eight maternal deaths, six neonatal deaths, seven stillbirths and five miscarriages were reported. Nineteen neonates were SARS\u2010CoV\u20102 positive, confirmed by reverse transcription polymerase chain reaction of nasopharyngeal swabs. [Correction added on 2 September 2020, after first online publication: the number of neonates indicated in the preceding sentence has been corrected from \u2018Thirteen\u2019 to \u2018Nineteen\u2019.]<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Where universal screening was conducted, SARS\u2010CoV\u20102 infection in pregnancy was often asymptomatic. Severe and critical disease rates approximate those in the general population. Vertical transmission is possible; however, it is unclear whether SARS\u2010CoV\u20102 positive neonates were infected <jats:italic>in utero<\/jats:italic>, intrapartum or postpartum. Future work should assess risks of congenital syndromes and adverse perinatal outcomes where infection occurs in early and mid\u2010pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13204","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T02:15:28Z","timestamp":1597112128000},"page":"640-659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["COVID\u201019 and pregnancy: A review of clinical characteristics, obstetric outcomes and vertical transmission"],"prefix":"10.1111","volume":"60","author":[{"given":"Elicia","family":"Pettirosso","sequence":"first","affiliation":[{"name":"The University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3007-1822","authenticated-orcid":false,"given":"Michelle","family":"Giles","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Monash University Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Cole","sequence":"additional","affiliation":[{"name":"Multiple Pregnancy Clinic The Royal Women's Hospital Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7736-4000","authenticated-orcid":false,"given":"Megan","family":"Rees","sequence":"additional","affiliation":[{"name":"The University of Melbourne Melbourne Victoria Australia"},{"name":"Department of Respiratory and Sleep Disorders Medicine The Royal Melbourne Hospital Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,10]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Coronavirus disease 2019 (COVID\u201019) Situation report \u2010 133","author":"who.int"},{"key":"e_1_2_5_3_1","volume-title":"Coronavirus disease 2019 (COVID\u201019) Situation report \u2013 46","author":"who.int"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","unstructured":"who.int [homepage on the internet].Geneva: World Health Organisation Interim guidance: Clinical management of severe acute respiratory infection (SARI) when COVID\u201019 disease is suspected. v1.2[Cited 21 April 2020]. 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