{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:42:04Z","timestamp":1791996124878,"version":"4.4.0"},"reference-count":7,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Current guidelines recommend that resolution of a complete molar pregnancy (CMP) can only be confirmed once a negative \u03b2\u2010human chorionic gonadotropin (\u03b2\u2010hCG) has been maintained for six months following uterine surgical evacuation. However, multiple studies have found that the risk of developing gestational trophoblastic neoplasia (GTN) once a negative \u03b2\u2010hCG had been obtained is negligible, which suggests that a shorter follow\u2010up may be reasonable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the trend in \u03b2\u2010hCG following diagnosis of a CMP and the incidence of GTN, in a single unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>All patients presenting to the tertiary hospital, Royal Prince Alfred Hospital Early Pregnancy Assessment Service (RPAH EPAS), with a histopathological diagnosis of a CMP between 2010 and 2017 were included. Data collected included age, parity, \u03b2\u2010hCG at diagnosis, subsequent \u03b2\u2010hCG levels, incidence of GTN and treatment required.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010seven patients were diagnosed with CMP between January 2010 and July 2017 through RPAH EPAS. The mean age of women diagnosed with a CMP was 33\u00a0years. None of the 40 patients who spontaneously achieved a negative \u03b2\u2010hCG and completed their six months follow\u2010up had a subsequent rise in \u03b2\u2010hCG. The median number of days from surgical evacuation to normalisation of \u03b2\u2010hCG was 55.5\u00a0days. Sixteen out of 67 patients who had a CMP required further management for persistent GTN. None of these patients achieved a negative \u03b2\u2010hCG prior to further management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Consideration could be made to decreasing the period of \u03b2\u2010hCG monitoring for women who achieve a spontaneous negative \u03b2\u2010hCG following surgical evacuation of a CMP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13258","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T02:05:58Z","timestamp":1602209158000},"page":"213-216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Assessment of current follow\u2010up for complete molar pregnancies: A single centre review"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5115-2982","authenticated-orcid":false,"given":"Gaithri","family":"Mylvaganam","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Royal Prince Alfred Hospital Sydney Australia"},{"name":"Department of Gynaecology Oncology Chris O\u2019Brien Lifehouse Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Allanson","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Oncology Chris O\u2019Brien Lifehouse Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Allanson","sequence":"additional","affiliation":[{"name":"Department of Tissue Pathology and Diagnostic Oncology Royal Prince Alfred Hospital Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Philp","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Oncology Chris O\u2019Brien Lifehouse Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvan","family":"Pather","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Oncology Chris O\u2019Brien Lifehouse Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda","family":"Farrell","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Oncology Chris O\u2019Brien Lifehouse Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3871-2815","authenticated-orcid":false,"given":"Jonathan","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Oncology Chris O\u2019Brien Lifehouse Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Tejada\u2010Berges","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Oncology Chris O\u2019Brien Lifehouse Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Management of Gestational 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Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajo.13258","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajo.13258","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajo.13258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T12:42:47Z","timestamp":1695904967000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/ajo.13258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,8]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/ajo.13258"],"URL":"https:\/\/doi.org\/10.1111\/ajo.13258","archive":["Portico"],"relation":{},"ISSN":["0004-8666","1479-828X"],"issn-type":[{"value":"0004-8666","type":"print"},{"value":"1479-828X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,8]]},"assertion":[{"value":"2019-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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