{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T02:59:40Z","timestamp":1784257180004,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Vulvodynia and pudendal neuralgia comprise significant contributors to vulvar\u2010related pain and its impact on daily life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>A retrospective clinical audit was conducted at the Women\u2019s Health &amp; Research Institute of Australia, Sydney, to determine the pattern of use and the efficacy of the application of topical amitriptyline 0.5% plus oestriol 0.03% in organogel (AOO), to the vulvar vestibule in reducing the impact of pain on daily life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>There were 1174 patients who received a script from May 2017 until February 2020: 1054 patients agreed to be contacted and had a valid email address.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 376 (35.7%) patients who replied. Pain with intercourse was the main indication for use. Treatment was rated effective by 51.2% (95% CI: 35.4\u201366.8%) of patients less than 30\u00a0years of age, 66.7% (95% CI: 57.3\u201374.9%) of patients 30\u201350\u00a0years of age, and 58.3% (95% CI: 50.9\u201365.4%) in patients over 50. Stinging at the site of application was the most commonly reported side effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Topical AOO is an effective and well\u2010tolerated treatment for vulvar pain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13292","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T04:55:26Z","timestamp":1610686526000},"page":"270-274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Topical treatment of vulvodynia, dyspareunia and pudendal neuralgia: A single clinic audit of amitriptyline and oestriol in organogel"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0229-6514","authenticated-orcid":false,"given":"Chantelle M.","family":"Ruoss","sequence":"first","affiliation":[{"name":"Women\u2019s Health and Research Institute of Australia (WHRIA) Sydney New South Wales 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