{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T05:48:34Z","timestamp":1781243314438,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In high income countries, ~30% of pregnant women are provided with intrapartum antibiotic prophylaxis (IAP) for early\u2010onset group B streptococcal infection (EOGBSI). The infection rate is low, 0.2\/1000 livebirths in our jurisdiction, and others. We hypothesised factors, other than IAP alone, were reasons for the low rate of EOGBSI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Compliance with our local guideline, referred to here as \u2018the guideline\u2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Compliance was defined as an initial dose of benzylpenicillin IAP followed by four\u2010hourly doses until birth. The study population was drawn from 4098 women who had 4100 pregnancies resulting in 4200 babies in an Australian birth setting from 1\/1\/2016 to 31\/12\/2016. Most, 93%, were eligible for universal GBS screening, 67% were reported as screened and 90% of these had a result documented; 23% were positive for GBS. A random sample (<jats:italic>n<\/jats:italic>\u00a0=\u00a0223) was taken for further analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The adjusted odds of receiving benzylpenicillin IAP in accord with the guideline were three times higher among primiparous compared to multiparous women (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, odds ratio (OR)\u00a0=\u00a03.4, 95% CI 1.7\u20136.7) and three times higher among women experiencing induction of labour compared to women who commenced labour spontaneously (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, OR\u00a0=\u00a03.4, 95% CI 1.8\u20136.3). Of the 223 women, 188 received IAP: 176 received benzylpenicillin IAP, 31% (or 24% of the total sample) received this intervention in accord with the guideline, 24% received benzylpenicillin \u22654\u00a0h before birth but not in accord with the guideline and 44% received benzylpenicillin &lt;4\u00a0h before birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that sub\u2010optimal compliance was largely a consequence of an unrealistic guideline.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13370","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T05:21:58Z","timestamp":1620969718000},"page":"870-875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intrapartum antibiotic prophylaxis for women who are screened positive for group B streptococcal colonisation: Clinical compliance with the guideline"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0309-2778","authenticated-orcid":false,"given":"Kathryn","family":"Braye","sequence":"first","affiliation":[{"name":"Faculty of Health University of Technology Sydney Sydney New South Wales Australia"},{"name":"Department of Maternity and gynaecology John Hunter Hospital Hunter New England Local Health District New Lambton New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Ferguson","sequence":"additional","affiliation":[{"name":"NSW Health Pathology John Hunter Hospital Hunter New England Local Health District New Lambton New South Wales Australia"},{"name":"The University of Newcastle Faculty of Health and Medicine Callaghan New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Ball","sequence":"additional","affiliation":[{"name":"Clinical Research Design IT and Statistical Support Unit (CReDITSS) The University of Newcastle Hunter Medical Research Institute New Lambton New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maralyn","family":"Foureur","sequence":"additional","affiliation":[{"name":"Hunter New England Local Health District, Nurses and Midwives Research Centre The University of Newcastle Callaghan New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30055-X"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61651-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.552652"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318280d4f6"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31821dc76f"},{"key":"e_1_2_5_7_1","first-page":"CD007467","article-title":"Intrapartum antibiotics for known maternal Group B streptococcal colonization","volume":"6","author":"Ohlsson A","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wombi.2017.10.012"},{"key":"e_1_2_5_9_1","first-page":"1","article-title":"Prevention of perinatal group B streptococcal disease: revised guidelines mortality and morbidity weekly report (MMWR)","volume":"59","author":"Centers for Disease Control and Prevention","year":"2010","journal-title":"Recommend Rep"},{"key":"e_1_2_5_10_1","article-title":"UK National Screening committee (UK NSC). 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