{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:58:31Z","timestamp":1773327511827,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Syphilis in pregnancy and congenital syphilis (CS) are increasing in Australia. Prevention of adverse outcomes requires adherence to management guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim is to evaluate the management of syphilis in pregnant women and their newborns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A retrospective study of public health notifications, clinical records and testing results of women with positive syphilis serology in pregnancy requiring treatment from 2016 to 2018 inclusive across South\u2010East Queensland was conducted. Management was described and compared with contemporary guidelines from the Australasian Society of Infectious Diseases, the Communicable Diseases Network Australia and the United States Centers for Disease Control and Prevention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 30 women identified, 22 (73%) had management consistent with the guidelines (stage\u2010appropriate penicillin regimen, appropriate dosing interval and treatment completed greater than 30\u00a0days before delivery). Only 14 (47%) women had documentation of partner testing and\/or treatment. Of 26 mother\u2013infant pairs with complete data, 16 (62%) had investigations at delivery consistent with recommendations (parallel maternal\u2013infant rapid plasma reagin, infant syphilis immunoglobulin M, placental histopathology +\/\u2013 syphilis polymerase chain reaction and infant clinical examination). One infant met the criteria for confirmed CS. Five infants received penicillin therapy. Only seven (27%) infants had serological monitoring after discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Management can be optimised with timely maternal testing and treatment, comprehensive partner screening and treatment, strict adherence to seven\u2010day penicillin dosing for late latent syphilis and thorough maternal and infant testing after treatment and delivery. If maternal treatment was inadequate in pregnancy, consideration needs to be given to close evaluation and empiric treatment of the infant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13424","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T16:26:41Z","timestamp":1630427201000},"page":"91-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Addressing the crisis of congenital syphilis: Key findings from an evaluation of the management of syphilis in pregnancy and the newborn in South\u2010East Queensland"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1604-8060","authenticated-orcid":false,"given":"Mandy","family":"Wu","sequence":"first","affiliation":[{"name":"Queensland Children\u2019s Hospital Brisbane Australia"},{"name":"School of Clinical Medicine University of Queensland Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy","family":"Seel","sequence":"additional","affiliation":[{"name":"Metro North Public Health Unit Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumudu","family":"Britton","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine University of Queensland Brisbane Australia"},{"name":"Royal Brisbane and Women\u2019s Hospital Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2513-2013","authenticated-orcid":false,"given":"Judith A.","family":"Dean","sequence":"additional","affiliation":[{"name":"School of Public Health Faculty of Medicine University of Queensland Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattea","family":"Lazarou","sequence":"additional","affiliation":[{"name":"School of Public Health Faculty of Medicine University of Queensland Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huda","family":"Safa","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department Mater Mothers\u2019 Hospital Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Griffin","sequence":"additional","affiliation":[{"name":"Infectious Diseases Mater Mothers\u2019 Hospital Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7246-8540","authenticated-orcid":false,"given":"Clare","family":"Nourse","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine University of Queensland Brisbane Australia"},{"name":"Infection Management and Prevention Service Queensland Children\u2019s Hospital Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"The Global Elimination of Congenital Syphilis. 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[Accessed 28\/07\/2020.] Available from URLhttps:\/\/ww2.health.wa.gov.au\/Articles\/J_M\/Metropolitan\u2010Perth\u2010syphilis\u2010outbreak\u2010alert?_cldee=ai5kZWFuNEB1cS5lZHUuYXU%3d&recipientid=contact\u201060af88ef75d3e41180ecc4346badb650\u201099705011ff804f20bf681bcde2d3c348&esid=8b4df1f8\u20108fe6\u2010ea11\u2010a817\u2010000d3ae15585."},{"key":"e_1_2_6_8_1","unstructured":"Victoria State Government.Congenital Syphilis in Victoria 2020. [Accessed 22\/07\/2020.] Available from URLhttps:\/\/www2.health.vic.gov.au\/about\/news\u2010and\u2010events\/healthalerts\/congenital\u2010syphilis."},{"key":"e_1_2_6_9_1","unstructured":"Notifications of Syphilis in Queensland 2019 Report. State of Queensland (Queensland Health);2020."},{"key":"e_1_2_6_10_1","unstructured":"Multijurisdictional Syphilis Outbreak Working Group.Multijurisdictional Syphilis Outbreak Surveillance Report: August 2020. 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