{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:37:30Z","timestamp":1774611450075,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Intraperitoneal local anaesthetic has shown benefit in operative laparoscopy; however, no randomised controlled trial has been reported with patients having diagnostic laparoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine the effect of intraperitoneal ropivacaine on post\u2010operative analgesic requirements, pain, nausea scores and recovery following gynaecological diagnostic laparoscopy and hysteroscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Randomised double\u2010blind placebo\u2010controlled trial. Well women aged 18\u201350\u00a0years, undergoing day case hysteroscopy and diagnostic laparoscopy for gynaecological indications were randomised to 20\u00a0mL of 150\u00a0mg intraperitoneal ropivacaine diluted in saline, or 20\u00a0mL normal saline instillation (placebo) at the end of the procedure. Women were followed up until eight hours post\u2010discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Slower than anticipated recruitment meant that the study was finished before the sample size of 100 patients was achieved. Fifty\u2010nine patients were included for analysis. Thirty\u2010one patients were randomised to ropivacaine and 28 patients to control. Sixty\u2010one percent of patients in both arms required opioid medication in recovery. The total median equivalent morphine dose was significantly higher in the patients randomised to control (11.7 mg) vs ropivacaine (6.7\u00a0mg), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03. Time to discharge was 20\u00a0min faster in patients randomised to ropivacaine, but this finding did not reach significance. Overall pain and nausea scores in the first eight hours showed no significant differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was significantly reduced opioid use in recovery when using intraperitoneal ropivacaine compared to placebo, in this randomised placebo\u2010controlled trial on women undergoing day case diagnostic laparoscopy and hysteroscopy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13439","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T18:02:52Z","timestamp":1634752972000},"page":"118-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The effect of intraperitoneal ropivacaine on post\u2010operative pain and recovery after diagnostic laparoscopy and hysteroscopy: A randomised double\u2010blind placebo\u2010controlled trial"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2876-3005","authenticated-orcid":false,"given":"Natasha","family":"Frawley","sequence":"first","affiliation":[{"name":"School of Medicine The University of Melbourne Melbourne Victoria Australia"},{"name":"Ballarat Health Services Ballarat Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Jones","sequence":"additional","affiliation":[{"name":"Monash Health Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora","family":"Pearce","sequence":"additional","affiliation":[{"name":"School of Population and Global Health The University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8756-3994","authenticated-orcid":false,"given":"Beverley","family":"Vollenhoven","sequence":"additional","affiliation":[{"name":"Monash Health Melbourne Victoria Australia"},{"name":"Monash University Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Royal Australian and New Zealand College of Obstetricians patient education website. 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