{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:49:22Z","timestamp":1791388162058,"version":"4.3.3"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T00:00:00Z","timestamp":1637452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["Postgraduate Scholarship"],"award-info":[{"award-number":["Postgraduate Scholarship"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There is a lack of evidence for pre\u2010eclampsia prophylaxis with aspirin in women with pre\u2010existing diabetes mellitus (DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the evidence for aspirin in pre\u2010eclampsia prophylaxis in women with pre\u2010existing DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>An electronic search using Ovid MEDLINE, Embase, CinicalTrials.gov and the Cochrane CENTRAL register of controlled trials through to February 2021 was performed. Reference lists of identified studies, previous review articles, clinical practice guidelines and government reports were manually searched. Randomised controlled trials (RCTs) of aspirin vs placebo for pre\u2010eclampsia prophylaxis were included. Articles were manually reviewed to determine if cohorts included women with DM. The systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses statement. Data from included trials were extracted independently by two authors who also independently assessed risk of bias as per the Cochrane Handbook criteria version 5.1.0. Data were analysed using Rev\u2010Man 5.4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty RCTs were identified, of which 11 included a confirmed subset of women with DM; however, data were insufficient for meta\u2010analysis. Meta\u2010analysis of 930 women with DM, from individual patient data included in a systematic review and unpublished data from one of the 11 RCTs, showed a non\u2010significant difference in the outcome of pre\u2010eclampsia in participants treated with aspirin compared to placebo (odds ratio 0.58; 95% CI 0.20\u20131.71; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.33).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pre\u2010eclampsia risk reduction with aspirin prophylaxis in women with pre\u2010existing DM may be similar to women without pre\u2010existing DM. However, randomised data within this meta\u2010analysis were insufficient, warranting the need for further studies within this high\u2010risk group of women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13460","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T06:59:45Z","timestamp":1637564385000},"page":"12-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Aspirin for the prevention of pre\u2010eclampsia in women with pre\u2010existing diabetes: Systematic review"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6441-9818","authenticated-orcid":false,"given":"Monica","family":"Zen","sequence":"first","affiliation":[{"name":"Westmead Institute for Maternal &amp; Fetal Medicine Westmead Hospital Sydney New South Wales Australia"},{"name":"Westmead Clinical School Faculty of Medicine and Health Westmead Hospital The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabbia","family":"Haider","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Nepean Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-0761","authenticated-orcid":false,"given":"David","family":"Simmons","sequence":"additional","affiliation":[{"name":"Macarthur Clinical School Western Sydney University Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Peek","sequence":"additional","affiliation":[{"name":"ANU Medical School The Australian National University Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Nolan","sequence":"additional","affiliation":[{"name":"ANU Medical School The Australian National University Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suja","family":"Padmanabhan","sequence":"additional","affiliation":[{"name":"Westmead Clinical School Faculty of Medicine and Health Westmead Hospital The University of Sydney Sydney New South Wales Australia"},{"name":"Department of Diabetes &amp; Endocrinology Westmead Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa","family":"Jesudason","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thushari I.","family":"Alahakoon","sequence":"additional","affiliation":[{"name":"Westmead Institute for Maternal &amp; Fetal Medicine Westmead Hospital Sydney New South Wales Australia"},{"name":"Westmead Clinical School Faculty of Medicine and Health Westmead Hospital The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6323-8006","authenticated-orcid":false,"given":"Ngai Wah","family":"Cheung","sequence":"additional","affiliation":[{"name":"Westmead Clinical School Faculty of Medicine and Health Westmead Hospital The University of Sydney Sydney New South Wales Australia"},{"name":"Department of Diabetes &amp; Endocrinology Westmead Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Westmead Clinical School Faculty of Medicine and Health Westmead Hospital The University of Sydney Sydney New South Wales Australia"},{"name":"Faculty of Health and Medical Sciences University of Adelaide Adelaide South Australia Australia"},{"name":"Department of Renal Medicine Westmead Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12629"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4004(91)90339-H"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1649882"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6111.467"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6661(200001\/02)9:1<62::AID-MFM13>3.0.CO;2-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.02.023"},{"key":"e_1_2_8_8_1","volume-title":"IDF Diabetes Atlas","author":"Federation; ID","year":"2019"},{"key":"e_1_2_8_9_1","unstructured":"WorldHealthOrganization.WHO recommendations for prevention and treatment of pre\u2010eclampsia and eclampsia. World Health Organization.2011. Available at:http:\/\/whqlibdocwhoint\/publications\/2011\/9789241548335_engpdf."},{"key":"e_1_2_8_10_1","unstructured":"National\u2010Institute\u2010for\u2010Health\u2010and\u2010Care\u2010Excellence.Hypertension in pregnancy: diagnosis and management. NICE clinical guideline 107.2010. Available at: niceorguk\/guidance\/cg107. updated January 2011."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10088.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92633-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704559"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(03)00169-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004659.pub2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322005000500010"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60712-0"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(15)30588-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","unstructured":"LoweSA BowyerL LustK McMahonLP MortonMR NorthRA PaechM SaidJM.SOMANZ guideline for the management of hypertensive disorders of pregnancy 2014.2015. Available at:https:\/\/wwwsomanzorg\/guidelinesasp.","DOI":"10.1111\/ajo.12399"},{"issue":"5","key":"e_1_2_8_20_1","first-page":"1122","article-title":"Hypertension in pregnancy. Report of the American College of obstetricians and gynecologists' task force on hypertension in pregnancy","volume":"122","author":"American College of O, Gynecologists, Task Force on Hypertension in P","year":"2013","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2013.09.019"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2019.11.002"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_8_24_1","unstructured":"HigginsJP GSe.Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0[updated March 2011]. The Cochrane Collaboration 2011.2011."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803123381101"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.12.781"},{"issue":"17","key":"e_1_2_8_27_1","first-page":"e426","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"138","author":"Whelton PK","year":"2018","journal-title":"Circulation"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92207-X"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91891-X"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90351-I"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70194-2"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1995.tb10872.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7329.71"},{"issue":"2","key":"e_1_2_8_34_1","first-page":"336","article-title":"24\u2010hour time\u2010dependent aspirin efficacy in patients with stable coronary artery disease","volume":"1","author":"Henry P","year":"2011","journal-title":"Thromb Haemost"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.03.013"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.06.008"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085566"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2007.05.002"},{"key":"e_1_2_8_39_1","first-page":"112","article-title":"Younger age, higher body mass index and lower adiponectin concentration predict higher serum thromboxane B2 level in aspirin\u2010treated patients with type 2 diabetes: an observational study","volume":"13","author":"Kaplon\u2010Cieslicka A","year":"2014","journal-title":"Cardiovasc"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta5330"},{"key":"e_1_2_8_41_1","first-page":"100465","article-title":"Investigating the role of early low\u2010dose aspirin in diabetes: A phase III multicentre double\u2010blinded placebo\u2010controlled randomised trial of aspirin therapy initiated in the first trimester of diabetes pregnancy. Contemporary Clinical Trials","volume":"16","author":"Finnegan C","year":"2019","journal-title":"Communications"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14149"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-018-2970-3"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641950109152635"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14889"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01747-1"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.7400"},{"issue":"5","key":"e_1_2_8_48_1","first-page":"826","article-title":"Usefulness of aspirin therapy in high\u2010risk pregnant women with abnormal uterine artery Doppler ultrasound at 14\u201316 weeks pregnancy: randomized controlled clinical trial","volume":"46","author":"Ebrashy A","year":"2005","journal-title":"Croat Med J"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2002.01046.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09513.x"}],"container-title":["Australian and New Zealand Journal of Obstetrics and Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajo.13460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajo.13460","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajo.13460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T12:28:23Z","timestamp":1693139303000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/ajo.13460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,21]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/ajo.13460"],"URL":"https:\/\/doi.org\/10.1111\/ajo.13460","archive":["Portico"],"relation":{},"ISSN":["0004-8666","1479-828X"],"issn-type":[{"value":"0004-8666","type":"print"},{"value":"1479-828X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,21]]},"assertion":[{"value":"2021-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}