{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:47:13Z","timestamp":1769597233501,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the results of microdissection testicular sperm extraction (micro\u2010TESE) and intracytoplasmic sperm injection (ICSI) for treatment of non\u2010obstructive azoospermia (NOA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We retrospectively analysed data of 88 consecutive patients with clinical NOA who were treated with micro\u2010TESE by a single surgeon, between August 2014 and September 2020, in Melbourne, Victoria. Upon a successful sperm retrieval, sperm was either used fresh for ICSI, frozen for future use or both. The outcome measures were sperm retrieval rate (SRR), and in vitro fertilisation (IVF)\/ICSI results. Furthermore, SRR was calculated for the predominant causes and histopathological patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall SRR was 61.2%. It was significantly higher in patients with a history of cryptorchidism and other childhood diseases (100%) than in the other NOA groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Patients with Klinefelter syndrome had a 75% SRR. Among the different types of testicular histology, the highest SRR were noted in patients with complete hyalinisation (100%) and hypospermatogenesis (92.9%), and low with Sertoli cell\u2010only syndrome (46.3%). The SRR has significantly increased from 33.3% in 2015\u20132016 to 73.6% in 2019\u20132020 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.009). Of the 52 patients with SSR, 47 underwent IVF\/ICSI. Fertilisation rate was 42.4%. Twenty\u2010nine couples achieved at least one good\u2010quality embryo and had embryo transfer. Nineteen achieved pregnancy (40.4%), and in three patients a miscarriage resulted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first report from Australia showing that micro\u2010TESE is an effective treatment for NOA with high SRR. The increasing success rates over several years indicate the importance of surgical skill and laboratory staff experience.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13477","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T01:58:53Z","timestamp":1643853533000},"page":"300-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Micro\u2010testicular sperm extraction outcomes for non\u2010obstructive azoospermia in a single large clinic in Victoria"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7106-1543","authenticated-orcid":false,"given":"Daniel","family":"Lantsberg","sequence":"first","affiliation":[{"name":"Reproductive Services Unit The\u00a0Royal Women\u2019s Hospital  Melbourne Victoria Australia"},{"name":"Lis Maternity Hospital Tel Aviv Medical Center  Tel Aviv Israel"},{"name":"Men\u2019s Health Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yossi","family":"Mizrachi","sequence":"additional","affiliation":[{"name":"Reproductive Services Unit The\u00a0Royal Women\u2019s Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0861-5643","authenticated-orcid":false,"given":"Darren J.","family":"Katz","sequence":"additional","affiliation":[{"name":"Men\u2019s Health Melbourne  Melbourne Victoria Australia"},{"name":"Department of Surgery Western Precinct University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Urology Western Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30043-2"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)62079-2"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03105-9"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2017.10.008"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmx008"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2010.08.006"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/HUMREP\/10.6.1457"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.1.131"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz028"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.4081\/aiua.2018.2.130"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.07.1136"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-020-02529-4"},{"key":"e_1_2_5_14_1","unstructured":"JungwirthA DiemerT KopaZ Krausz\u200fC.EAU Guidelines on. uroweb.org\u200f [Internet]2019[cited 2021 Sep 2]; 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