{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:42:43Z","timestamp":1774327363917,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Adenomyosis is a benign disorder defined by ectopic endometrial glands within the uterine myometrium. A study by Mooney et al reported the myometrial\u2010cervical ratio (MCR), a novel ultrasound measurement that was found to improve the preoperative diagnosis of adenomyosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To validate the association between sonographic MCR and adenomyosis confirmed on histopathology in an independent patient group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Single\u2010centre retrospective cohort study including women who underwent hysterectomy between 1 January 2016 and 31 December 2018 for a benign, non\u2010obstetric indication with an ultrasound at the study centre prior to surgery. Clinical details and histopathology were extracted. Ultrasound images were reviewed by a gynaecology ultrasound subspecialist blinded to histological findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight hundred eighty\u2010seven patients underwent hysterectomy in the study period for eligible indications; 317 had an ultrasound at the study centre and were included. There was no statistically significant association between the MCR and adenomyosis on histology when all patients were included; however, increased MCR was associated with adenomyosis when those with fibroids on ultrasound were excluded. The area under the receiver operating characteristic for this model was 0.614 (95% CI: 0.53 to 0.69). The optimal MCR cut\u2010point in this subgroup was 1.79, which achieved 55.6% sensitivity and 62.8% specificity, with 58.5% correctly classified. There was no significant difference in MCR compared to traditional ultrasound markers of adenomyosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a population undergoing hysterectomy for benign and non\u2010obstetric indications, the MCR applied to preoperative ultrasound was only weakly associated with a histological diagnosis of adenomyosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13515","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T07:04:36Z","timestamp":1646982276000},"page":"560-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The use of the myometrial\u2010cervical ratio in the ultrasound diagnosis of adenomyosis \u2013 A validation study"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0987-4401","authenticated-orcid":false,"given":"Tristan","family":"McCaughey","sequence":"first","affiliation":[{"name":"The Royal Women's Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5742-9148","authenticated-orcid":false,"given":"Samantha","family":"Mooney","sequence":"additional","affiliation":[{"name":"The Mercy Women's Hospital  Melbourne Victoria Australia"},{"name":"Department Obstetrics &amp; Gynaecology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keryn","family":"Harlow","sequence":"additional","affiliation":[{"name":"The Royal Women's Hospital  Melbourne Victoria Australia"},{"name":"The Mercy Women's Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Healey","sequence":"additional","affiliation":[{"name":"The Royal Women's Hospital  Melbourne Victoria Australia"},{"name":"Department Obstetrics &amp; Gynaecology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Stone","sequence":"additional","affiliation":[{"name":"The Mercy Women's Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(72)90781-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2006.01.006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-016-0185-6"},{"issue":"3","key":"e_1_2_6_5_1","first-page":"163","article-title":"Adenomyosis: prevalence, risk factors, symptoms and clinical findings","volume":"34","author":"Yeniel O","year":"2007","journal-title":"Clin Exp Obstet Gynecol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des332"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2016.09.006"},{"issue":"5","key":"e_1_2_6_8_1","first-page":"688","article-title":"Adenomyosis: symptoms, histology, and pregnancy terminations","volume":"95","author":"Levgur M","year":"2000","journal-title":"Obstet Gynecol"},{"issue":"2","key":"e_1_2_6_9_1","first-page":"105","article-title":"The preoperative diagnosis of adenomyosis","volume":"4","author":"Weseley AC","year":"1982","journal-title":"Diagn Gynecol Obstet"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2018.01.013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.19.suppl_1.g99oc13s147"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.06.009"},{"issue":"3","key":"e_1_2_6_13_1","first-page":"177","article-title":"Diagnosis of adenomyosis: a review","volume":"52","author":"Levgur M","year":"2007","journal-title":"J Reprod Med"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.13434"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14806"},{"key":"e_1_2_6_16_1","unstructured":"ClaytonP.CUTPT: Stata module for empirical estimation of cutpoint for a diagnostic test. 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