{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:49:38Z","timestamp":1780591778170,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1104136"],"award-info":[{"award-number":["1104136"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1174523"],"award-info":[{"award-number":["1174523"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010invasive prenatal screening (NIPS) is being increasingly used by expectant parents. Much provision of this test in Australia is occurring in clinical settings where specialised genetic counselling is unavailable, such as general practice. Potential psychosocial consequences from this kind of prenatal genetic screening remain largely unexplored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To explore clinicians' experiences with NIPS for aneuploidy, their perspectives of the benefits and harms of NIPS, clinicians' information needs, and their perceptions of the needs of expectant parents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Qualitative, semi\u2010structured interviews with 17 health professionals (clinical geneticists, obstetricians, genetic counsellors and general practitioners) who request and counsel for NIPS in Australian hospital and private practice settings, conducted between June 2019 and February 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five themes were identified relating to clinicians' perceptions and experiences of NIPS in their practice: perceived benefits of NIPS, perceived harms of NIPS (with two subthemes: clinical harms and psychosocial harms), financial and equity\u2010related concerns, counselling as a protective buffer against perceived harms, and clinicians' unmet education needs. While clinicians view NIPS as a useful and high\u2010quality screening test, especially for detection of common trisomies, many participants had concerns about how NIPS has been implemented in practice, particularly the quality (and often absence) of pre\u2010\/post\u2010test counselling and the routinisation of testing for sex chromosome aneuploidies, microdeletion and microduplication syndromes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings support the need for targeted clinician training around NIPS, and for a shared decision\u2010making approach to support expectant parents' autonomous decisions about NIPS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13533","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T05:03:49Z","timestamp":1652245429000},"page":"830-837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinician views and experiences of non\u2010invasive prenatal genetic screening tests in Australia"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6384-1745","authenticated-orcid":false,"given":"Shannon","family":"McKinn","sequence":"first","affiliation":[{"name":"Wiser Healthcare, Sydney School of Public Health, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasrin","family":"Javid","sequence":"additional","affiliation":[{"name":"Sydney Institute for Women, Children and their Families Sydney Local Health District  Sydney New South Wales Australia"},{"name":"Royal Prince Alfred Hospital Women and Babies Ambulatory Care Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainsley J.","family":"Newson","sequence":"additional","affiliation":[{"name":"Bioethics, Wiser Healthcare and Sydney Health Ethics, Sydney School of Public Health, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucinda","family":"Freeman","sequence":"additional","affiliation":[{"name":"School of Women and Children's Health University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carissa","family":"Bonner","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4200-9295","authenticated-orcid":false,"given":"Antonia W.","family":"Shand","sequence":"additional","affiliation":[{"name":"Children's Hospital at Westmead Clinical School, Faculty of Medicine and Health The University of Sydney  Sydney Australia"},{"name":"Royal Hospital for Women Department of Maternal Fetal Medicine  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Nassar","sequence":"additional","affiliation":[{"name":"Paediatric and Perinatal Epidemiology, Children's Hospital at Westmead Clinical School, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy J.L.","family":"Bell","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology, Wiser Healthcare, Sydney School of Public Health, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-083118-015053"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17484"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-072115-033220"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-021-00941-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001091"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31352"},{"key":"e_1_2_8_8_1","unstructured":"Royal Australian and New Zealand College of Obstetricians and Gynecologists human genetics Society of Australia.Prenatal screening and diagnostic testing for fetal chromosomal and genetic conditions (C\u2010Obs59).2018. RANZCOG. [Accessed Sep 2021.] Available from:https:\/\/ranzcog.edu.au\/RANZCOG_SITE\/media\/RANZCOG\u2010MEDIA\/Women%27sHealth\/Statementandguidelines\/Clinical\u2010Obstetrics\/Prenatal\u2010screening_1.pdf?ext=.pdf."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004084"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.10.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50928"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-021-01101-4"},{"key":"e_1_2_8_13_1","unstructured":"Medical Services Advisory Committee.Public summary document: application no. 1492 \u2013 non\u2010invasive prenatal testing (NIPT) for trisomies 21 18 and 13.Canberra:MSAC 2019. 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