{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:10:41Z","timestamp":1791216641119,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T00:00:00Z","timestamp":1661040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015988","name":"Norman Beischer Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015988","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>An incidental finding of a thickened endometrium on ultrasound in the postmenopausal patient without bleeding is a common presentation to gynaecological services; however there is limited evidence to guide clinical practice as to when hysteroscopic evaluation and endometrial sampling is required.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine the endometrial thickness at which endometrial sampling is indicated in asymptomatic postmenopausal women referred with thickened endometrium on ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A single\u2010centre retrospective case series of postmenopausal women without bleeding undergoing hysteroscopy was conducted. Logistic regression was used to examine the association between a range of variables and pre\u2010malignant or malignant pathology and endometrial thickness. The optimal endometrial thickness threshold was identified to maximise model sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 404 postmenopausal women were included in this study, having undergone a hysteroscopy at the study site between 1 July 2008 and 30 June 2018. The mean (SD) age of patients at presentation was 65 (9.09) years and the mean body mass index was 29.86\u2009kg\/m<jats:sup>2<\/jats:sup> (6.52). Of these women, nine (2.2%) were diagnosed with endometrial carcinoma and seven (1.7%) had endometrial hyperplasia with atypia. The most common histopathological finding was of a benign endometrial polyp (153: 37.9%). When including hyperplasia with or without atypia in histopathology of interest, a cut\u2010off of \u22659\u2009mm provides the greatest sensitivity (83.3%) and specificity (63.8%) for a diagnosis of pre\u2010malignant or malignant pathology (classification accuracy of 64.8%; area under the receiver operating characteristic: 0.7358, 95% CI: 0.6439, 0.8278) in this cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Using an endometrial thickness of \u22659\u2009mm can be used as a cut\u2010off for endometrial sampling in postmenopausal women without bleeding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13604","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T03:53:44Z","timestamp":1661140424000},"page":"887-893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Determining a threshold measurement of endometrial thickness for asymptomatic postmenopausal women: A tertiary centre case series"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9850-4797","authenticated-orcid":false,"given":"Amy","family":"Stewart","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Peninsula Health  Melbourne Victoria Australia"},{"name":"Mercy Hospital for Women  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurjot","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Readman","sequence":"additional","affiliation":[{"name":"Mercy Hospital for Women  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5183-2892","authenticated-orcid":false,"given":"Sonia R.","family":"Grover","sequence":"additional","affiliation":[{"name":"Mercy Hospital for Women  Melbourne Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5742-9148","authenticated-orcid":false,"given":"Samantha S.","family":"Mooney","sequence":"additional","affiliation":[{"name":"Mercy Hospital for Women  Melbourne Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,21]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"GallosID AlazzamM ClarkTJet al.Management of Endometrial Hyperplasia. Green\u2010top Guideline No. 67 2016. [Accessed on July 24 2021.] Available from URL:https:\/\/www.rcog.org.uk\/globalassets\/documents\/guidelines\/green\u2010top\u2010guidelines\/gtg_67_endometrial_hyperplasia.pdf"},{"key":"e_1_2_6_3_1","unstructured":"Australian Institute of Health and Welfare (AIHW) 2017.Australian Cancer Incidence and Mortality (ACIM) books.Canberra:AIHW. 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