{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:46:05Z","timestamp":1792597565245,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>KEY POINTS<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy liver disease, characterised by pruritus and increased total serum bile acids (TSBA), Australian incidence 0.6\u20130.7%.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>ICP is diagnosed by <jats:bold>non\u2010fasting<\/jats:bold> TSBA <jats:italic>\u2265<\/jats:italic>19\u2009\u03bcmol\/L in a pregnant woman with pruritus without rash without a known pre\u2010existing liver disorder.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Peak TSBA <jats:italic>\u2265<\/jats:italic>40 and\u2009<jats:italic>\u2265<\/jats:italic>100\u2009\u03bcmol\/L identify severe and very severe disease respectively, associated with spontaneous preterm birth when severe, and with stillbirth, when very severe.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Benefit\u2010vs\u2010risk for iatrogenic preterm birth in ICP remains uncertain.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Ursodeoxycholic acid remains the best pharmacotherapy preterm, improving perinatal outcome and reducing pruritus, although it has not been shown to reduce stillbirth.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/ajo.13719","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T08:55:07Z","timestamp":1689065707000},"page":"656-665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Intrahepatic cholestasis of pregnancy \u2013 Diagnosis and management: A consensus statement of the Society of Obstetric Medicine of Australia and New Zealand (<scp>SOMANZ<\/scp>): Executive summary"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5355-2955","authenticated-orcid":false,"given":"William M.","family":"Hague","sequence":"first","affiliation":[{"name":"Robinson Research Institute The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Briley","sequence":"additional","affiliation":[{"name":"Women's Health &amp; 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