{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:15:44Z","timestamp":1760660144074,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fluoroscopic hysterosalpingography (HSG) with Lipiodol\u00ae is safe and has a therapeutic effect on fertility: transient in endometriosis\u2010related infertility and sustained in unexplained infertility. Ultrasound is replacing fluoroscopy as the preferred imaging modality for HSG due to comfort and radiation safety (no ionising radiation). The safety of ultrasound\u2010guided Lipiodol\u00ae HSG is uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Prospectively observe pregnancy and complication rates after ultrasound\u2010guided Lipiodol\u00ae HSG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A single\u2010centre prospective study of women with unexplained infertility undergoing ultrasound\u2010guided Lipiodol\u00ae uterine bathing and tubal flushing after tubal patency confirmed with ExEm\u00ae Foam HyFoSy (hysterosalpingo\u2010foam\u2010sonography). Pregnancy outcomes at six\u2009months and serum and urinary thyroid function at one, three and eight weeks were recorded. Pain scores were recorded during and immediately after HSG. Descriptive statistics are reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010two participants were enrolled between July 2019 and April 2021, median age 33\u2009years (range 21\u201345). Only 45 (87%, 45\/52) completed the Lipiodol\u00ae HSG; 5\/7 experienced intravasation during initial HyFoSy. Of 30 women at follow\u2010up, 57% had biochemical (17\/30, 95% CI 37%\u201375%), 53% clinical (16\/30 95% CI 34%\u201372%) and 35% ongoing pregnancies (11\/30, 95% CI 20%\u201356%). The rate of subclinical hypothyroidism (SCH) at two months was 41% (7\/17). One intravasation event occurred during Lipiodol\u00ae HSG (2%, 1\/45). Median pain score was 5\/10 (range 0\u20139, interquartile range 2.5\u20137). No anaphylaxis, infection or oil embolism was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Outpatient ultrasound\u2010guided Lipiodol\u00ae HSG was safe, with pregnancy rates comparable to previous studies of fluoroscopic guidance. Rates of intravasation and SCH were also similar, confirming the need to monitor thyroid function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13794","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T06:00:28Z","timestamp":1706767228000},"page":"326-333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ultrasound\u2010guided Lipiodol\u00ae hysterosalpingography: A prospective study on pregnancy and complication rates"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6906-588X","authenticated-orcid":false,"given":"Glen","family":"Lo","sequence":"first","affiliation":[{"name":"Western Ultrasound For Women  Perth Western Australia Australia"},{"name":"King Edward Memorial Hospital  Perth Western Australia Australia"},{"name":"Sir Charles Gairdner Osborne Park Health Group  Perth Western Australia Australia"},{"name":"Curtin University Medical School  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3630-3356","authenticated-orcid":false,"given":"Dana","family":"Hince","sequence":"additional","affiliation":[{"name":"Institute for Health Research, The University of Notre Dame  Fremantle Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Johnson","sequence":"additional","affiliation":[{"name":"Flinders University  Adelaide South Australia Australia"},{"name":"Auckland Gynaecology Group and Repromed Auckland  Auckland New Zealand"},{"name":"Flinders Medical Centre and Flinders Fertility  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul L.","family":"Hofman","sequence":"additional","affiliation":[{"name":"Liggins Institute University of Auckland  Auckland New 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