{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T20:15:24Z","timestamp":1769631324855,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Microvascular scarring compromises the functionality of the endometrium, and vascular flow at the junctional zone (JZ) may be the key to understanding poor reproductive outcomes in women with Asherman syndrome (AS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate whether vascular perfusion of the uterus, measured by dynamic contrast\u2010enhanced magnetic resonance imaging (DCE\u2010MRI) is impaired in women with intrauterine adhesions (IUA) and AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A prospective observational cohort pilot study of 23 women with IUA treated with hysteroscopic synecholysis and a control group of two patients with cervix cancer were subject to DCE\u2010MRI with gadolinium to assess uterine vascularity. Twelve regions of interest (ROIs) were allocated on the DCE\u2010MRI image incorporating the JZ, with control ROI placed at the psoas muscle. Individual ROIs were compared to the mean total perfusion (TP) in the same uterus. Pre\u2010 and post\u2010operative perfusion analyses were performed on five women. Receiver operator curves (ROC) were used to analyse MRI as a predictor of IUA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in perfusion; a trend toward reduced perfusion was observed in women with IUA compared to the controls. The ROC was predictive of higher\u2010grade and inoperable IUA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Reduced perfusion on DCE\u2010MRI as assessed by ROC predicted higher\u2010stage AS. The results of this study support further investigation of DCE\u2010MRI as a prognostic tool for AS prior to surgical intervention to assist in providing prognostic guidance for women suffering from AS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13799","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T03:33:51Z","timestamp":1708054431000},"page":"341-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Perfusion magnetic resonance imaging in Asherman syndrome"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7932-550X","authenticated-orcid":false,"given":"Rebecca","family":"Deans","sequence":"first","affiliation":[{"name":"School of Women's and Children's Health, University of New South Wales  Sydney New South Wales Australia"},{"name":"Royal Hospital for Women  Sydney New South Wales 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