{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T18:37:54Z","timestamp":1773859074368,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate the indications for maternal TORCH (<jats:italic>Toxoplasma gondii<\/jats:italic>, rubella, cytomegalovirus (CMV), and herpes simplex virus (HSV)) serology, with a focus on the yield in isolated fetal growth restriction (FGR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A retrospective review of antenatal TORCH testing between January 2014 and December 2018 was carried out at two hospitals in Melbourne, Australia. TORCH testing ordered for pregnancy losses and stillbirth was excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Medical records of 718 pregnancies were reviewed, representing 760 fetuses. Isolated FGR was the indication for TORCH screening in 71.2% of pregnancies. Screens ordered for isolated FGR were positive in 7.4% (95% CI 5.5\u201310.0%). There were 49 positive maternal immunoglobulin M (CMV\u2009=\u200934, <jats:italic>Toxoplasma<\/jats:italic>\u2009=\u200915). Two acute maternal infections during pregnancy were diagnosed (CMV\u2009=\u20091, <jats:italic>Toxoplasma<\/jats:italic>\u2009=\u20091), with both screens ordered to assess symptomatic maternal illness. There was one neonatal CMV infection, born to a woman with symptomatic primary CMV. No maternal or neonatal rubella or HSV infections were identified. We found a diagnostic yield of TORCH screening for isolated FGR of 0.0% (95% CI 0.00\u20130.8%). An estimated AUD$64\u2009269.75 was expended on maternal TORCH screens in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal TORCH testing for isolated FGR is of no diagnostic yield and should be abandoned.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13802","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T04:49:07Z","timestamp":1708490947000},"page":"354-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical utility of maternal TORCH screening in fetal growth restriction: A retrospective two\u2010centre study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0413-0218","authenticated-orcid":false,"given":"Christine A.","family":"Wade","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Austin Health  Melbourne Victoria Australia"},{"name":"Department of Infectious Diseases Northern Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Northern Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha E.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Austin Health  Melbourne Victoria Australia"},{"name":"Department of Infectious Diseases The University of Melbourne at the Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"},{"name":"Department of Perinatal Medicine Mercy Hospital for Women  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9720-3562","authenticated-orcid":false,"given":"Lisa","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Northern Health  Melbourne Victoria Australia"},{"name":"Department of Perinatal Medicine Mercy Hospital for Women  Melbourne Victoria Australia"},{"name":"Department of Obstetrics, Gynaecology and Newborn Medicine The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197108000-00144"},{"issue":"6","key":"e_1_2_7_3_1","first-page":"352","article-title":"Influence of infection on fetal growth and development","volume":"21","author":"Knox GE","year":"1978","journal-title":"J Reprod Med"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1242"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.05.010"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6073"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2018.10.039"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2013.872609"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13522"},{"key":"e_1_2_7_10_1","unstructured":"Choosing Wisely Australia.Choosing Wisely Australia: An Initiative of NPS MedicineWise.2016. 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