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This approach is not supported by the available evidence, which shows that very early losses are just as prognostically important as clinical losses. Clinical pregnancy is a biologically meaningless construct and is not a suitable method for determining whether a loss is \u2018valid\u2019 or not. The exclusion extends to clinical trials, where treatment is often not initiated until clinical pregnancy has been established. Treatment opportunities are being missed as a result. This exclusion of early pregnancy needs to stop.<\/jats:p>","DOI":"10.1111\/ajo.70033","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T21:37:28Z","timestamp":1743197848000},"page":"867-869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["It's Time to Stop Excluding Early Pregnancy (Losses)"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0949-8293","authenticated-orcid":false,"given":"Miranda","family":"Aalderink","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.13821"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7271.1259"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead040"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu042"},{"key":"e_1_2_4_6_1","unstructured":"The ESHRE Guideline Group on RPL R.Bender Atik O. 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