{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:15:25Z","timestamp":1790129725938,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100015988","name":"Norman Beischer Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015988","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Preterm prelabour rupture of membranes (PPROM) is a common obstetric complication with significant maternal and foetal consequences. There is a lack of contemporary evidence regarding the optimal management of PPROM, including the best antibiotic regimen and management at previable gestations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To understand the contemporary management of PPROM among clinicians in Australia and Aotearoa New Zealand.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>An anonymous web\u2010based survey was designed and distributed, consisting of 31 questions about individual clinicians' routine management of PPROM across a range of different gestations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The survey was completed by 235 clinicians from across Australia and Aotearoa New Zealand. The majority (225\/232, 97%) routinely prescribed prophylactic antibiotics after PPROM, with 90 different antibiotic regimens documented. The most commonly prescribed prophylactic antibiotics were erythromycin (198\/225, 88%) and penicillins (103\/225, 46%). There was variation in practice regarding the timing of birth after PPROM, with 62% (147\/235) routinely delaying birth until after 37\u2009weeks of gestation, and 61% (143\/235) expediting birth after 34\u2009weeks of gestation if Group B\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      was cultured antenatally. For previable PPROM (&lt;\u200922\u2009weeks of gestation), 74% (171\/232) of women were routinely admitted to hospital at the time of diagnosis and 77% (173\/225) were routinely offered antibiotics. There was significant variation in the earliest gestational ages at which antenatal corticosteroids and resuscitation are offered.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We observed wide variation in clinical practice of management of PPROM. With a lack of national consensus regarding optimal management of this common pregnancy complication, contemporary clinical trials to define best practices are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajo.70039","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T01:50:38Z","timestamp":1745977838000},"page":"824-830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinician's Approach to Antibiotic Treatment and Management of Preterm Prelabour Rupture of Membranes (\n                    <scp>PPROM<\/scp>\n                    ) in Australia and Aotearoa New Zealand\u2014A Survey"],"prefix":"10.1111","volume":"65","author":[{"given":"Sonia","family":"Kua","sequence":"first","affiliation":[{"name":"Department of Maternal Fetal Medicine Royal Women's Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6162-0305","authenticated-orcid":false,"given":"Amanda","family":"Poprzeczny","sequence":"additional","affiliation":[{"name":"The Robinson Research Institute and Department of Obstetrics and Gynaecology The University of Adelaide  Adelaide Australia"},{"name":"Department of Obstetrics and Gynaecology The Women's and Children's Hospital, Women's and Babies Division  Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Groom","sequence":"additional","affiliation":[{"name":"Liggins Institute University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Payne","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynaecology, UWA Medical School University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9983-7457","authenticated-orcid":false,"given":"John","family":"Newnham","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynaecology, UWA Medical School University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Manley","sequence":"additional","affiliation":[{"name":"Newborn Research and Neonatal Services The Royal Women's Hospital  Melbourne Australia"},{"name":"Department of Obstetrics, Gynaecology and Newborn Health University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8267-1630","authenticated-orcid":false,"given":"Clare L.","family":"Whitehead","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine Royal Women's Hospital  Melbourne Australia"},{"name":"Department of Obstetrics, Gynaecology and Newborn Health University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Preterm Pre\u2010Labour Rupture of Membranes","author":"Safer Care Victoria","year":"2017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471\u20100528.15803"},{"key":"e_1_2_8_4_1","volume-title":"Prelabor Rupture of Membranes Before and at the Limit of Viability","author":"McElrath T.","year":"2024"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21884"},{"key":"e_1_2_8_6_1","volume-title":"Prophylactic Antibiotics in Obstetrics and 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