{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:12:11Z","timestamp":1773015131449,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Using a Gonadotrophin Releasing Hormone Agonist (GnRHa) trigger and freezing all eggs or embryos is the most effective strategy for preventing Ovarian Hyperstimulation Syndrome (OHSS) in IVF cycles. The literature predominantly suggests that severe OHSS can virtually be eliminated using the GnRHa trigger. The aim of this study was to determine the clinical characteristics and disease severity of OHSS in patients who received a GnRHa trigger compared to standard Human Chorionic Gonadotropin (HCG) trigger.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study of patients with OHSS admitted to a single tertiary referral hospital over a five\u2010year period, from January 2016 to December 2021. HCG and GnRHa trigger cohorts were compared with respect to baseline characteristics, IVF cycle characteristics and OHSS outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 150 cases of severe OHSS requiring admission, 24 (16%) occurred after a GnRHa trigger and 126 (84%) occurred after an HCG trigger. Baseline characteristics were not significantly different. Baseline AMH and the number of oocytes retrieved were significantly higher in the GnRHa group ((69.6 versus 41.4\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and (28.3 versus 21.7\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0038) respectively). There was no significant difference in most markers of clinical severity or length of hospital admission.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Using a GnRHa trigger and freeze\u2010all protocol reduces but does not eliminate OHSS in high\u2010risk women. Further preventative strategies may be necessary in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajo.70072","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T05:29:03Z","timestamp":1763443743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Severe Ovarian Hyperstimulation Syndrome (\n                    <scp>OHSS<\/scp>\n                    ) After Gonadotrophin Releasing Hormone Agonist (\n                    <scp>GnRHa<\/scp>\n                    ) Triggering"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5040-1142","authenticated-orcid":false,"given":"Olivia","family":"Slifirski","sequence":"first","affiliation":[{"name":"The Royal Women's Hospital  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genia","family":"Rozen","sequence":"additional","affiliation":[{"name":"Reproductive Services Unit, the Royal Women's Hospital  Parkville Victoria Australia"},{"name":"Melbourne IVF  East Melbourne Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6531-4786","authenticated-orcid":false,"given":"Chase","family":"Medwin","sequence":"additional","affiliation":[{"name":"The Royal Women's Hospital  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nassar","family":"Nassar","sequence":"additional","affiliation":[{"name":"Reproductive Services Unit, the Royal Women's Hospital  Parkville Victoria Australia"},{"name":"Melbourne IVF  East Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Polyakov","sequence":"additional","affiliation":[{"name":"Reproductive Services Unit, the Royal Women's Hospital  Parkville Victoria Australia"},{"name":"Melbourne IVF  East Melbourne Victoria Australia"},{"name":"Faculty of Medicine, Dentistry and Health Sciences University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.08.048"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/8.6.559"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.13688"},{"key":"e_1_2_6_5_1","unstructured":"Royal College of Obstetricians & Gynaecologists \u201cThe Management of Ovarian Hyperstimulation Syndrome: Green\u2010Top Guideline No. 5 \u201d(2016)."},{"issue":"1","key":"e_1_2_6_6_1","first-page":"11","article-title":"Update on Ovarian Hyperstimulation Syndrome: Part 1\u2014Incidence and Pathogenesis","volume":"52","author":"Binder H.","year":"2007","journal-title":"International Journal of Fertility and Women's Medicine"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(17)30070-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.07.1292"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh638"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei475"},{"issue":"3","key":"e_1_2_6_11_1","first-page":"248","article-title":"Ovarian Hyperstimulation Syndrome: A Narrative Review of Its Pathophysiology, Risk Factors, Prevention, Classification, and Management","volume":"43","author":"Namavar Jahromi B. 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