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The pelvic milieu comprising immature dendritic cells, dysfunctional cytotoxic lymphocytes, and an imbalance in production of interleukin\u201012 isoforms including Type I\/II interferons (IFNs) is thought to play a major role in this process. The recent discovery of an immunomodulating lipidic peptide, designated IK14004, that activates natural killer (NK) and CD8+ T cells, skews IL\u201012 signalling towards the IL\u201012p70 isoform and uncouples production of Type I from Type II IFNs may enable earlier diagnosis of endometriosis and could also have therapeutic benefit.<\/jats:p>","DOI":"10.1111\/ajo.70123","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T07:27:44Z","timestamp":1774942064000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Immunomodulating Peptide With Potential to Counteract Endometriosis"],"prefix":"10.1111","volume":"66","author":[{"given":"Michael","family":"Agrez","sequence":"first","affiliation":[{"name":"InterK Peptide Therapeutics Limited  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2021.103462"},{"issue":"3","key":"e_1_2_4_3_1","first-page":"911","article-title":"Interleukin\u201012 and Its Free p40 Subunit Regulate Immune Recognition of Endometrial Cells: Potential Role in Endometriosis","volume":"83","author":"Mazzeo D.","year":"1998","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2916070"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55224-8"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13786"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.14002"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-15455-5"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-47229-y"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8091468"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12111554"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-010-9321-x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105539"},{"key":"e_1_2_4_14_1","article-title":"Toll\u2010Like Receptor 2\u2010Tpl2\u2010Dependent ERK Signaling Drives Inverse Interleukin 12 Regulation in Dendritic Cells and Macrophages","volume":"89","author":"Groft S. 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