{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:41:26Z","timestamp":1787568086890,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Progesterone elevation (PE) is perceived as the product of cumulative secretion of low levels of progesterone from multiple developing follicles and is commonly present in high responders. Therefore, PE occurring with an unexpectedly low number of follicles potentially represents a different pathophysiological entity such as follicular dysregulation, which may reflect poorer follicular and oocyte quality, which is not yet well studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine if progesterone elevation is associated with oocyte or embryo quality in patients with 1\u20134 follicles \u2265\u200910\u2009mm on the day of triggering final oocyte maturation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a multi\u2010centre retrospective cohort study of 1393 IVF\/ICSI cycles with a low response (1\u20134 follicles \u2265\u200910\u2009mm) to ovarian stimulation performed from January 2018 to April 2022. Unexpected PE was defined as serum progesterone levels &gt;\u20094.77\u2009nmol\/L on the day of triggering final oocyte maturation. The primary outcome was the number of usable Day 5 blastocysts. Generalised estimating equations were used to account for the clustered nature of data and to adjust for the effect of multiple confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A negative association of PE with the primary outcome measure of this study was shown in the multivariable regression analysis where the number of usable blastocysts was significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) lower in the PE group (adjusted mean 0.18, 95% CI 0.07\u20130.28) compared to the non\u2010PE group (adjusted mean 0.27, 95% CI 0.24\u20130.31) after adjusting for confounders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PE on day of triggering final oocyte maturation is negatively associated with fertilisation rates and the number of usable blastocysts in patients with 1\u20134 follicles \u2265\u200910\u2009mm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajo.70160","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:47:32Z","timestamp":1784011652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Progesterone Elevation on the Day of Triggering Final Oocyte Maturation Is Associated With Decreased Oocyte and Embryo Quality in Low Responders"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7045-3484","authenticated-orcid":false,"given":"Yin Jun","family":"Law","sequence":"first","affiliation":[{"name":"Department of Maternity and Gynaecology John Hunter Hospital  Newcastle New South Wales 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