{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:24:27Z","timestamp":1791595467391,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Endometrial cancer is the most common gynaecological malignancy in Australia. Patients diagnosed in their reproductive window may desire a fertility\u2010sparing approach, opposed to standard surgical care. International guidelines on fertility\u2010sparing management exist; however, these highlight the lack of high\u2010level evidence to support the recommendations. There are no Australian\u2010specific guidelines or registries, leading to uncertainty as to how patients are managed locally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To survey clinicians in Australia regarding fertility\u2010sparing management of endometrial cancer, to identify areas of consensus and variation, barriers to care and research priorities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A 47\u2010item online survey was distributed to clinicians who manage patients with endometrial cancer in Australia between November 2024 and January 2025. Responses were analysed descriptively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 70 eligible clinicians, 56% responded. There was agreement on appropriate candidate selection for FIGO grade 1 disease with absent\/focal myoinvasion, use of hysteroscopy for diagnosis, and preference for levonorgestrel intra\u2010uterine device as initial therapy. Opinions were divided on management of patients with Lynch syndrome or more extensive myoinvasion, the diagnostic utility of endometrial pipelle, and treatment of recurrences. POLE mutation testing and hysteroscopic resection were uncommon practices. Most respondents referred patients to fertility specialists, while other members of the multi\u2010disciplinary team were less frequently utilised. The most frequent research priorities were weight\u2010loss strategies (31%) and molecular profiling (27%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinicians in Australia have common approaches to diagnosis and first\u2010line therapy, but there is variation in patient selection, surveillance and engagement with a multi\u2010disciplinary team. These discrepancies highlight the potential benefits of local guidelines and further research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajo.70176","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:02:36Z","timestamp":1789628556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fertility\u2010Sparing Treatment of Endometrial Cancer: Survey of Australian Practice"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6770-9394","authenticated-orcid":false,"given":"Harrison","family":"Odgers","sequence":"first","affiliation":[{"name":"Department of Gynaecologic Oncology Chris O'Brien Lifehouse, Camperdown  Sydney New South Wales Australia"},{"name":"Sydney Medical School The University of Sydney, Camperdown  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7036-8968","authenticated-orcid":false,"given":"Rhonda","family":"Farrell","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology Chris O'Brien Lifehouse, Camperdown  Sydney New South Wales Australia"},{"name":"Sydney Medical School The University of Sydney, Camperdown  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00323-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0832"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14030751"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2020-002230"},{"key":"e_1_2_8_6_1","first-page":"506","article-title":"An Ecological Evaluation of the Increasing Incidence of Endometrial Cancer and the Obesity Epidemic","volume":"224","author":"Smrz S. A.","year":"2021","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.01.036"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.19169"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoac057"},{"key":"e_1_2_8_10_1","unstructured":"National Comprehensive Cancer Network \u201cClinical Practice Guidelines in Oncology Uterine Neoplasms Version 3.2025 \u201daccessed June 2025 https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/uterine.pdf."},{"key":"e_1_2_8_11_1","unstructured":"New Zealand Gynaecologic Cancer Group \u201cFertility\u2010Preserving Management of Early Endometrial Cancer \u201d(2023) accessed June 2025 https:\/\/www.tewhatuora.govt.nz\/assets\/Publications\/Cancer\/NZGCG\u2010Fertility\u2010Preserving\u2010Management\u2010of\u2010Early\u2010Endometrial\u2010Cancer.pdf."},{"key":"e_1_2_8_12_1","volume-title":"Optimal Care Pathway for Women With Endometrial Cancer, Second Edition","author":"Cancer Council of Australia","year":"2021"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5662\/wjm.v11.i4.116"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2013.12.002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000524"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2023.04.027"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5515-y"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-020-05551-0"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2016.08.004"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.12.017"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22351"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djae210"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijgc.2024.100033","article-title":"Laparoscopic Bariatric Surgery With Hysterectomy for Endometrial Cancer to Improve Long\u2010Term Outcomes: A Review Article","volume":"35","author":"Goddard E.","year":"2024","journal-title":"International Journal of Gynecological Cancer"},{"key":"e_1_2_8_25_1","article-title":"What Is Best for Weight Loss? A Comparative Review of the Safety and Efficacy of Bariatric Surgery Versus Glucagon\u2010Like Peptide\u20101 Analogue","volume":"15","author":"Klair N.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2024.07.008"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30496"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgc.2024.100016"},{"key":"e_1_2_8_29_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijgc.2024.100024","article-title":"The Prognostic Impact of Molecular Classification in Endometrial Cancer That Undergoes Fertility\u2010Sparing Treatment","volume":"35","author":"Luigi A.","year":"2025","journal-title":"International Journal of Gynecological Cancer"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(25)00167-6"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgc.2025.101644"},{"key":"e_1_2_8_32_1","doi-asserted-by":"crossref","DOI":"10.3802\/jgo.2017.28.e16","article-title":"Hysteroscopy in Fertility\u2010Sparing Management for Early Endometrial Cancer: A Double\u2010Edged Sword","volume":"28","author":"Park J.\u2010Y.","year":"2017","journal-title":"Journal of Gynecologic Oncology"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2020.101794"}],"container-title":["Australian and New Zealand Journal of Obstetrics and Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajo.70176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajo.70176","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajo.70176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:02:42Z","timestamp":1789628562000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/ajo.70176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,17]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/ajo.70176"],"URL":"https:\/\/doi.org\/10.1111\/ajo.70176","archive":["Portico"],"relation":{},"ISSN":["0004-8666","1479-828X"],"issn-type":[{"value":"0004-8666","type":"print"},{"value":"1479-828X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,17]]},"assertion":[{"value":"2025-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70176"}}