{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:25:57Z","timestamp":1753878357386,"version":"3.41.2"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian J Rural Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to analyse the clinical presentation caused by enterovirus (EV) and\/or human parechovirus (HPeV) infection in children, as well as the management of such cases admitted to a regional hospital in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study reviewing medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single hospital in regional Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>All children under 18\u2009years admitted over the 5\u2010year period beginning from 1 January 2017 with confirmed EV and\/or HPeV infection. Cases with clinically insignificant EV\/HPeV isolation were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Data collected included demographic data, signs and symptoms present, specimens of EV\/HPeV isolation, co\u2010occurring pathogens, peak C\u2010reactive protein (CRP), antibiotic therapy, discharge diagnosis and follow\u2010up after discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 27 patients fulfilled the inclusion criteria; 81.5% of the patients were \u22643\u2009months of age with a median of 2\u2009months (interquartile range 1\u20133); 74.1% were males. The most common clinical features were a fever \u226538\u00b0C and irritability\/lethargy\/high\u2010pitched cry. 29.6% of the patients had co\u2010occurring pathogens detected, and a CRP \u226410\u2009mg\/L was observed in 77.8% of cases. All but two children were treated with antibiotics while awaiting polymerase chain reaction results. The most common discharge diagnosis was meningitis. In all, 74.1% of the children attended follow\u2010up appointments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EV and HPeV should be considered as a possible aetiology of fever and irritability\/lethargy\/high\u2010pitched cry in children under 3\u2009months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajr.13160","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T11:44:07Z","timestamp":1721389447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical presentation and management of enterovirus and parechovirus infection in children: A single\u2010centre study in regional Australia"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5726-1604","authenticated-orcid":false,"given":"Tharmarajah","family":"Sorubarajan","sequence":"first","affiliation":[{"name":"Rockhampton Base Hospital  Rockhampton Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sivapriyan","family":"Sorubarajan","sequence":"additional","affiliation":[{"name":"James Cook University  Townsville Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2018.02.007"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-016-2725-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6718a2"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja18.00149"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.DMIH2-0006-2015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.33321\/cdi.2022.46.55"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz685"},{"key":"e_1_2_10_9_1","unstructured":"NSW Health.Enteroviruses and human parechoviruses \u2013 information for clinicians. Updated May 23 2018. Accessed 15 Aug 2023."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piv030"},{"key":"e_1_2_10_11_1","first-page":"37","article-title":"Parechovirus and enterovirus infections in neonates","author":"Kielar M","year":"2019","journal-title":"Folia Med Cracov"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-315643"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.881516"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiac311"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/431511"}],"container-title":["Australian Journal of Rural Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajr.13160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T11:44:11Z","timestamp":1721389451000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajr.13160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,19]]},"references-count":14,"alternative-id":["10.1111\/ajr.13160"],"URL":"https:\/\/doi.org\/10.1111\/ajr.13160","archive":["Portico"],"relation":{},"ISSN":["1038-5282","1440-1584"],"issn-type":[{"type":"print","value":"1038-5282"},{"type":"electronic","value":"1440-1584"}],"subject":[],"published":{"date-parts":[[2024,7,19]]},"assertion":[{"value":"2023-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ajr.13160"}}