{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T14:25:58Z","timestamp":1777127158564,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian J Rural Health"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study is to determine if there are differences in outcome for patients diagnosed with multiple myeloma in a rural setting compared to a metropolitan setting and which factors influence these outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Illawarra Shoalhaven Local Health District.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participant<jats:bold>s<\/jats:bold><\/jats:title><jats:p>A total of 391 patients diagnosed with multiple myeloma between 2000 and 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Treatment and survival outcomes of these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients being treated in a rural cancer care centre had lower overall survival compared to those treated at a metropolitan cancer care centre (median OS\u2009=\u200944.4\u2009months vs. 80.2\u2009months, <jats:italic>p<\/jats:italic>\u2009=\u20090.002), despite access to similar treatments by the same group of haematologists. There was a significantly higher rate of upfront autologous transplantation (38% vs. 20%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) and higher rate of inclusion in clinical trials (16% vs. 7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.021) in patients treated at a metropolitan cancer care centre compared to the rural cancer care centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Multiple myeloma patients treated at a rural centre had shorter survival compared to patients treated at a metropolitan centre, and this may be related to lower rates of autologous transplantation and inclusion in clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajr.13189","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T17:04:29Z","timestamp":1727975069000},"page":"1207-1215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Differences in survival of patients with multiple myeloma in rural versus metropolitan regions: Analysis of population data of an Australian local health district"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3044-1419","authenticated-orcid":false,"given":"Sylvia","family":"Ai","sequence":"first","affiliation":[{"name":"Department of Haematology Wollongong Hospital  Wollongong New South Wales Australia"},{"name":"University of Wollongong  Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amarinder","family":"Thind","sequence":"additional","affiliation":[{"name":"University of Wollongong  Wollongong New South Wales Australia"},{"name":"Research Central Wollongong Hospital  Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurdeep","family":"Parmar","sequence":"additional","affiliation":[{"name":"Department of Haematology Wollongong Hospital  Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"243","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"McKenna RW","year":"2017"},{"key":"e_1_2_10_3_1","unstructured":"Cancer data in Australia [Internet]. 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