{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:23:20Z","timestamp":1787761400705,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian J Rural Health"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>THE CHALLENGE<\/jats:title>\n                    <jats:p>Rural and remote clinicians frequently make treatment decisions under conditions of uncertainty, exacerbated by limited access to specialist services, fewer locally available treatment options, and evidence that may not fully inform care for an individual patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>THE OPPORTUNITY<\/jats:title>\n                    <jats:p>N\u2010of\u20101 trials and related single\u2010case experimental designs (SCEDs) offer a structured method for generating individual\u2010level evidence to support treatment decisions yet remain rarely used in routine clinical practice. Beyond informing care for individual patients, aggregated N\u2010of\u20101 trials can also generate evidence that is directly relevant to rural populations and models of care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>IMPLICATIONS<\/jats:title>\n                    <jats:p>This editorial outlines the potential of N\u2010of\u20101 trials and SCEDs in rural and remote health and argues that increasing awareness, training, and practical support could enable their wider adoption.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajr.70241","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:43:33Z","timestamp":1786686213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Strengthening Rural Health With N\u2010of\u20101 Trials and Single\u2010Case Experimental Designs"],"prefix":"10.1111","volume":"34","author":[{"given":"Jane","family":"Nikles","sequence":"first","affiliation":[{"name":"RECOVER Injury Research Centre, Surgical, Treatment and Rehabilitation Service (STARS), The University of Queensland  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1745-4987","authenticated-orcid":false,"given":"Suzanne","family":"McDonald","sequence":"additional","affiliation":[{"name":"General Practice Clinical Unit, Medical School The University of Queensland  Brisbane Australia"},{"name":"Faculty of Health, Southern Cross University  Bilinga Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2425"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12961-024-01270-z"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/520609a"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2013.04.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198604033141406"},{"key":"e_1_2_9_7_1","unstructured":"OCEBM Levels of Evidence Working Group \u201cThe Oxford 2011 Levels of Evidence \u201daccessed 23 July 2026 https:\/\/www.cebm.ox.ac.uk\/resources\/levels\u2010of\u2010evidence\/ocebm\u2010levels\u2010of\u2010evidence."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.3981"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-7200-6_3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2031173"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00045391-200501000-00012"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-2299(03)00122-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel195"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1589\/jpts.31.39"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.17761\/2024-D-22-00077"},{"key":"e_1_2_9_16_1","first-page":"30","article-title":"Single Case Experimental Design Examining Cognitive Behavioural Therapy for Post\u2010Stroke Depression","volume":"11","author":"Myles L. 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