{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:19:28Z","timestamp":1780377568718,"version":"3.54.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":3563,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1111\/ajt.12068","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T17:08:12Z","timestamp":1358442492000},"page":"589-599","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Pretransplant Antithymocyte Globulin Has Increased Efficacy in Controlling Donor-Reactive Memory T Cells in Mice"],"prefix":"10.1016","volume":"13","author":[{"given":"K.","family":"Ayasoufi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Valujskikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/ajt.12068_bib1","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/j.1600-6143.2004.00453.x","article-title":"Memory T cells in transplantation: Generation, function, and potential role in rejection","volume":"4","author":"Bingaman","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12068_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.tp.0000226082.17507.da","article-title":"The impact of memory T cells on rejection and the induction of tolerance","volume":"82","author":"Brook","year":"2006","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12068_bib3","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1600-6143.2005.01215.x","article-title":"The challenge of inhibiting alloreactive T cell memory","volume":"6","author":"Valujskikh","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12068_bib4","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/MOT.0b013e3283061126","article-title":"Targeting T cell memory: Where do we stand?","volume":"13","author":"Valujskikh","year":"2008","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1111\/ajt.12068_bib5","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1681\/ASN.2007020151","article-title":"Frontiers in nephrology: T cell memory as a barrier to transplant tolerance","volume":"18","author":"Valujskikh","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/ajt.12068_bib6","doi-asserted-by":"crossref","first-page":"5456","DOI":"10.4049\/jimmunol.172.9.5456","article-title":"In vivo helper functions of alloreactive memory CD4+ T cells remain intact despite donor-specific transfusion and anti-CD40 ligand therapy","volume":"172","author":"Chen","year":"2004","journal-title":"J Immunol"},{"key":"10.1111\/ajt.12068_bib7","doi-asserted-by":"crossref","first-page":"770","DOI":"10.4049\/jimmunol.176.2.770","article-title":"Lymphoid sequestration of alloreactive memory CD4 T cells promotes cardiac allograft survival","volume":"176","author":"Zhang","year":"2006","journal-title":"J Immunol"},{"key":"10.1111\/ajt.12068_bib8","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1600-6143.2007.02096.x","article-title":"ICOS-Dependent and -independent functions of memory CD4 T cells in allograft rejection","volume":"8","author":"Zhang","year":"2008","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12068_bib9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1600-6143.2008.02460.x","article-title":"Effector functions of donor-reactive CD8 memory T cells are dependent on ICOS induced during division in cardiac grafts","volume":"9","author":"Schenk","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12068_bib10","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1111\/j.1600-6143.2008.02302.x","article-title":"Donor-reactive CD8 memory T cells infiltrate cardiac allografts within 24-h posttransplant in naive recipients","volume":"8","author":"Schenk","year":"2008","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12068_bib11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.trim.2004.05.009","article-title":"Tolerance induction in clinical transplantation","volume":"13","author":"Fehr","year":"2004","journal-title":"Transpl Immunol"},{"key":"10.1111\/ajt.12068_bib12","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.2165\/00003495-200868150-00004","article-title":"Tolerance-inducing immunosuppressive strategies in clinical transplantation: An overview","volume":"68","author":"Golshayan","year":"2008","journal-title":"Drugs"},{"key":"10.1111\/ajt.12068_bib13","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1432-2277.2008.00788.x","article-title":"Depleting T cell subpopulations in organ transplantation","volume":"22","author":"Haudebourg","year":"2009","journal-title":"Transpl Int"},{"key":"10.1111\/ajt.12068_bib14","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/sj.leu.2404683","article-title":"Mechanisms of action of antithymocyte globulin: T cell depletion and beyond","volume":"21","author":"Mohty","year":"2007","journal-title":"Leukemia"},{"key":"10.1111\/ajt.12068_bib15","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1111\/j.1600-6143.2006.01703.x","article-title":"Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft","volume":"7","author":"Koyama","year":"2007","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12068_bib16","doi-asserted-by":"crossref","first-page":"5584","DOI":"10.4049\/jimmunol.179.8.5584","article-title":"OX40 controls functionally different T cell subsets and their resistance to depletion therapy","volume":"179","author":"Kroemer","year":"2007","journal-title":"J Immunol"},{"key":"10.1111\/ajt.12068_bib17","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.4049\/jimmunol.176.8.4632","article-title":"Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it","volume":"176","author":"Neujahr","year":"2006","journal-title":"J Immunol"},{"key":"10.1111\/ajt.12068_bib18","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1600-6143.2006.01641.x","article-title":"Recovery of functional memory T cells in lung transplant recipients following induction therapy with alemtuzumab","volume":"7","author":"Zeevi","year":"2007","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12068_bib19","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1097\/01.tp.0000235910.47214.67","article-title":"No synergy between ATG induction and costimulation blockade induced kidney allograft survival in rhesus monkeys","volume":"82","author":"Haanstra","year":"2006","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12068_bib20","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1600-6143.2005.00759.x","article-title":"Immunocompetent T cells with a memory-like phenotype are the dominant cell type following antibody-mediated T cell depletion","volume":"5","author":"Pearl","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12068_bib21","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/TP.0b013e3181abc061","article-title":"In vivo characterization of rabbit anti-mouse thymocyte globulin: A surrogate for rabbit anti-human thymocyte globulin","volume":"88","author":"Ruzek","year":"2009","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12068_bib22","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1111\/j.1600-6143.2009.02820.x","article-title":"Memory T cell predominance following T cell depletional therapy derives from homeostatic expansion of naive T cells","volume":"9","author":"Sener","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12068_bib23","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1034\/j.1600-6143.2002.20603.x","article-title":"Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice","volume":"2","author":"Valujskikh","year":"2002","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12068_bib24","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1111\/j.1600-6143.2007.01971.x","article-title":"Synergistic deposition of C4d by complement-activating and non-activating antibodies in cardiac transplants","volume":"7","author":"Murata","year":"2007","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12068_bib25","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1182\/blood-2007-08-106526","article-title":"Characterization of in vitro antimurine thymocyte globulin-induced regulatory T cells that inhibit graft-versus-host disease in vivo","volume":"111","author":"Ruzek","year":"2008","journal-title":"Blood"},{"key":"10.1111\/ajt.12068_bib26","doi-asserted-by":"crossref","first-page":"12698","DOI":"10.1073\/pnas.1207219109","article-title":"Unexpected role for MHC II-peptide complexes in shaping CD8 T cell expansion and differentiation in vivo","volume":"109","author":"Do","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/ajt.12068_bib27","first-page":"250","article-title":"Enzyme linked immunosorbent spot (ELISPOT) assay for detection of alloreactive cytokine-secreting cells\u2014detailed methods","volume":"3","author":"Valujskikh","year":"2000","journal-title":"Graft"},{"key":"10.1111\/ajt.12068_bib28","doi-asserted-by":"crossref","first-page":"352","DOI":"10.4049\/jimmunol.162.1.352","article-title":"Contributions of direct and indirect T cell alloreactivity during allograft rejection in mice","volume":"162","author":"Benichou","year":"1999","journal-title":"J Immunol"},{"key":"10.1111\/ajt.12068_bib29","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1097\/00007890-199804150-00008","article-title":"High-resolution characterization of cytokine-producing alloreactivity in naive and allograft-primed mice","volume":"65","author":"Matesic","year":"1998","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12068_bib30","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1172\/JCI8082","article-title":"Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection","volume":"104","author":"Trambley","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1111\/ajt.12068_bib31","doi-asserted-by":"crossref","first-page":"6849","DOI":"10.4049\/jimmunol.165.12.6849","article-title":"Genetic characterization of strain differences in the ability to mediate CD40\/CD28-independent rejection of skin allografts","volume":"165","author":"Williams","year":"2000","journal-title":"J Immunol"},{"key":"10.1111\/ajt.12068_bib32","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/TP.0b013e3181e64217","article-title":"A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model","volume":"90","author":"D\u2019Addio","year":"2010","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12068_bib33","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/TP.0b013e31822923f7","article-title":"Murine antithymocyte globulin T cell depletion is mediated predominantly by macrophages, but the Fas\/FasL pathway selectively targets regulatory T cells","volume":"92","author":"Neff","year":"2011","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12068_bib34","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1097\/00007890-199706270-00018","article-title":"Expression of chemokine genes during rejection and long-term acceptance of cardiac allografts","volume":"63","author":"Fairchild","year":"1997","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12068_bib35","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1097\/00007890-199606270-00015","article-title":"Induction of chemokine gene expression during allogeneic skin graft rejection","volume":"61","author":"Kondo","year":"1996","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12068_bib36","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1097\/00007890-199103000-00024","article-title":"Antibodies against functional leukocyte surface molecules in polyclonal antilymphocyte and antithymocyte globulins","volume":"51","author":"Bonnefoy-Berard","year":"1991","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12068_bib37","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1097\/01.TP.0000053198.99206.E6","article-title":"Functional antibodies to leukocyte adhesion molecules in antithymocyte globulins","volume":"75","author":"Michallet","year":"2003","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12068_bib38","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/01.tp.0000251975.81281.22","article-title":"Antithymocyte globulins suppress dendritic cell function by multiple mechanisms","volume":"83","author":"Naujokat","year":"2007","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12068_bib39","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1097\/00007890-199504270-00020","article-title":"Comparative polyclonal antithymocyte globulin and antilymphocyte\/antilymphoblast globulin anti-CD antigen analysis by flow cytometry","volume":"59","author":"Bourdage","year":"1995","journal-title":"Transplantation"},{"issue":"Suppl 4","key":"10.1111\/ajt.12068_bib40","first-page":"217","article-title":"Increased intra-graft FoxP3+ T cells and cardiac allograft survival with pre-transplant administration of ATG","volume":"10","author":"Gao","year":"2010","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12068_bib41","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1111\/j.1600-6143.2010.03210.x","article-title":"Immune reconstitution following rabbit antithymocyte globulin","volume":"10","author":"Gurkan","year":"2010","journal-title":"Am J Transplant"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.12068","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522258481?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522258481?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:00:05Z","timestamp":1761627605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522258481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S1600613522258481"],"URL":"https:\/\/doi.org\/10.1111\/ajt.12068","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pretransplant Antithymocyte Globulin Has Increased Efficacy in Controlling Donor-Reactive Memory T Cells in Mice","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.12068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}