{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:18:29Z","timestamp":1780499909409,"version":"3.54.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":3190,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1111\/ajt.12572","type":"journal-article","created":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T10:47:16Z","timestamp":1389091636000},"page":"677-684","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Alemtuzumab and Sirolimus in Renal Transplantation: Six-Year Results of a Single-Arm Prospective Pilot Study"],"prefix":"10.1016","volume":"14","author":[{"given":"A.I.","family":"Sutherland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.Z.","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zilvetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Brockmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ruse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.V.","family":"Fuggle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Harden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"Friend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/ajt.12572_bib1","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1097\/01.TP.0000123082.31092.53","article-title":"Wound-healing complications after kidney transplantation: A prospective, randomized comparison of sirolimus and tacrolimus","volume":"77","author":"Dean","year":"2004","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12572_bib2","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1111\/j.1600-6143.2005.01123.x","article-title":"Alemtuzumab induction and sirolimus plus mycophenolate mofetil maintenance for CNI and steroid-free kidney transplant immunosuppression","volume":"5","author":"Flechner","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12572_bib3","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1097\/TP.0b013e3181613e65","article-title":"Poor tolerance of sirolimus in a steroid avoidance regimen for renal transplantation","volume":"85","author":"Smith","year":"2008","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12572_bib4","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1056\/NEJM200012143432417","article-title":"Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients","volume":"343","author":"Singer","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1111\/ajt.12572_bib5","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/S0140-6736(05)77739-4","article-title":"Prope tolerance, perioperative Campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients","volume":"351","author":"Calne","year":"1998","journal-title":"Lancet"},{"key":"10.1111\/ajt.12572_bib6","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1111\/j.1600-6143.2005.01067.x","article-title":"Alemtuzumab induction and prednisone-free maintenance immunotherapy in kidney transplantation: Comparison with basiliximab induction\u2014Long-term results","volume":"5","author":"Kaufman","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12572_bib7","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/j.1600-6143.2004.00515.x","article-title":"Long-term renal allograft survival: Have we made significant progress or is it time to rethink our analytic and therapeutic strategies?","volume":"4","author":"Meier-Kriesche","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12572_bib8","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/01.TP.0000128636.70499.6E","article-title":"Calcineurin inhibitor nephrotoxicity: Longitudinal assessment by protocol histology","volume":"78","author":"Nankivell","year":"2004","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12572_bib9","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1097\/01.tp.0000178393.78084.9b","article-title":"Superior outcomes in renal transplantation after early cyclosporine withdrawal and sirolimus maintenance therapy, regardless of baseline renal function","volume":"80","author":"Russ","year":"2005","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12572_bib10","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1056\/NEJMoa067411","article-title":"Reduced exposure to calcineurin inhibitors in renal transplantation","volume":"357","author":"Ekberg","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1111\/ajt.12572_bib11","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1182\/blood.V73.6.1431.1431","article-title":"Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: Influence of antibody isotype","volume":"73","author":"Dyer","year":"1989","journal-title":"Blood"},{"key":"10.1111\/ajt.12572_bib12","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/0140-6736(92)92294-P","article-title":"Humanised monoclonal antibody therapy for rheumatoid arthritis","volume":"340","author":"Isaacs","year":"1992","journal-title":"Lancet"},{"key":"10.1111\/ajt.12572_bib13","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0140-6736(94)91339-0","article-title":"Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis","volume":"344","author":"Moreau","year":"1994","journal-title":"Lancet"},{"key":"10.1111\/ajt.12572_bib14","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/00007890-198908000-00013","article-title":"Campath-1M-prophylactic use after kidney transplantation. A randomized controlled clinical trial","volume":"48","author":"Friend","year":"1989","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12572_bib15","first-page":"869","article-title":"Successful treatment of renal allograft rejection with a humanized antilymphocyte monoclonal antibody","volume":"27","author":"Friend","year":"1995","journal-title":"Transplant Proc"},{"key":"10.1111\/ajt.12572_bib16","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1111\/j.1600-6143.2005.00822.x","article-title":"Alemtuzumab (CAMPATH 1H) induction therapy in cadaveric kidney transplantation\u2014Efficacy and safety at five years","volume":"5","author":"Watson","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12572_bib17","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1034\/j.1600-6143.2003.00120.x","article-title":"Campath-1H induction plus rapamycin monotherapy for renal transplantation: Results of a pilot study","volume":"3","author":"Knechtle","year":"2003","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12572_bib18","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/01.TP.0000071362.99021.D9","article-title":"Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (CAMPATH-1H)","volume":"76","author":"Kirk","year":"2003","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12572_bib19","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1399-0012.2009.01082.x","article-title":"Long-term results after conversion from calcineurin inhibitors to sirolimus in renal transplant patients","volume":"24","author":"Martinez-Mier","year":"2010","journal-title":"Clin Transplant"},{"key":"10.1111\/ajt.12572_bib20","doi-asserted-by":"crossref","first-page":"505","DOI":"10.7326\/0003-4819-144-7-200604040-00009","article-title":"Brief communication: Sirolimus-associated pneumonitis: 24 cases in renal transplant recipients","volume":"144","author":"Champion","year":"2006","journal-title":"Ann Intern Med"},{"key":"10.1111\/ajt.12572_bib21","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1093\/ndt\/gfm420","article-title":"Pneumonitis associated with sirolimus: Clinical characteristics, risk factors and outcome\u2014A single-centre experience and review of the literature","volume":"22","author":"Weiner","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"10.1111\/ajt.12572_bib22","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/j.1600-6143.2009.02581.x","article-title":"Early and limited use of tacrolimus to avoid rejection in an alemtuzumab and sirolimus regimen for kidney transplantation: Clinical results and immune monitoring","volume":"9","author":"Knechtle","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12572_bib23","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1097\/01.tp.0000260142.38619.9c","article-title":"Rapamycin inhibits proliferation of Epstein\u2013Barr virus-positive B-cell lymphomas through modulation of cell-cycle protein expression","volume":"83","author":"Vaysberg","year":"2007","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12572_bib24","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1111\/j.1600-6143.2007.01972.x","article-title":"Dissociation of depletional induction and posttransplant lymphoproliferative disease in kidney recipients treated with alemtuzumab","volume":"7","author":"Kirk","year":"2007","journal-title":"Am J Transplant"},{"issue":"Suppl 1","key":"10.1111\/ajt.12572_bib25","doi-asserted-by":"crossref","first-page":"i27","DOI":"10.1093\/ndt\/gfm088","article-title":"Post-transplant lymphoproliferative disorder\u2014The potential of proliferation signal inhibitors","volume":"22","author":"Pascual","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"10.1111\/ajt.12572_bib26","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1056\/NEJMoa1009546","article-title":"Alemtuzumab induction in renal transplantation","volume":"364","author":"Hanaway","year":"2011","journal-title":"N Engl J Med"},{"issue":"4 Pt 1","key":"10.1111\/ajt.12572_bib27","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1600-6143.2005.00776.x","article-title":"Analysis of factors that influence survival with post-transplant lymphoproliferative disorder in renal transplant recipients: The Israel Penn International Transplant Tumor Registry experience","volume":"5","author":"Trofe","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12572_bib28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/2047-1440-2-7","article-title":"Campath, calcineurin inhibitor reduction and chronic allograft nephropathy (3C) study: Background, rationale, and study protocol","volume":"2","author":"Haynes","year":"2013","journal-title":"Transplant Res"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.12572","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522253842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522253842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:02:44Z","timestamp":1761627764000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522253842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S1600613522253842"],"URL":"https:\/\/doi.org\/10.1111\/ajt.12572","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alemtuzumab and Sirolimus in Renal Transplantation: Six-Year Results of a Single-Arm Prospective Pilot Study","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.12572","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}