{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:56:38Z","timestamp":1791176198002,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":3005,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1111\/ajt.12816","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T15:47:55Z","timestamp":1407340075000},"page":"2001-2010","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Abrogation of Renal Allograft Tolerance in MGH Miniature Swine: The Role of Intra-Graft and Peripheral Factors in Long-Term Tolerance"],"prefix":"10.1016","volume":"14","author":[{"given":"J.R.","family":"Scalea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Okumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Villani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.C.","family":"Gillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Torabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Cormack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Moran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"LeGuern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.H.","family":"Sachs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/ajt.12816_bib1","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1073\/pnas.92.7.2800","article-title":"Molecular identification of porcine interleukin-10: Regulation of expression in a kidney allograft model","volume":"92","author":"Blancho","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/ajt.12816_bib2","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00007890-199405150-00002","article-title":"Development of tolerance to class II mismatched renal transplants following a short course of cyclosporine therapy in miniature swine","volume":"57","author":"Fishbein","year":"1994","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12816_bib3","first-page":"322","article-title":"Interleukin-2 reverses the ability of cyclosporine to induce tolerance to class I disparate kidney allografts in miniature swine","volume":"25","author":"Fishbein","year":"1993","journal-title":"Transplant Proc"},{"key":"10.1111\/ajt.12816_bib4","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/00007890-199209000-00020","article-title":"Induction of specific tolerance to class I disparate renal allografts in miniature swine with cyclosporine","volume":"54","author":"Rosengard","year":"1992","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12816_bib5","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1084\/jem.186.4.497","article-title":"Role of the thymus in transplantation tolerance in miniature swine. I. Requirement of the thymus for rapid and stable induction of tolerance to class I-mismatched renal allografts","volume":"186","author":"Yamada","year":"1997","journal-title":"J Exp Med"},{"key":"10.1111\/ajt.12816_bib6","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1097\/01.TP.0000116416.10799.C6","article-title":"Role of the thymus in transplantation tolerance in miniature Swine: IV. The thymus is required during the induction phase, but not the maintenance phase, of renal allograft tolerance","volume":"77","author":"Vagefi","year":"2004","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12816_bib7","doi-asserted-by":"crossref","first-page":"550","DOI":"10.4049\/jimmunol.162.1.550","article-title":"Peripheral tolerance to class I mismatched renal allografts in miniature swine: Donor antigen-activated peripheral blood lymphocytes from tolerant swine inhibit antidonor CTL reactivity","volume":"162","author":"Ierino","year":"1999","journal-title":"J Immunol"},{"key":"10.1111\/ajt.12816_bib8","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1097\/00007890-199808270-00007","article-title":"Mechanism of tolerance to class I-mismatched allografts in miniature swine: Regulation of interleukin-2 receptor a-chain expression on CD8 peripheral blood lymphocytes of tolerant animals","volume":"66","author":"Ierino","year":"1998","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12816_bib9","doi-asserted-by":"crossref","first-page":"4788","DOI":"10.4049\/jimmunol.153.10.4788","article-title":"Mechanism of cyclosporin-induced tolerance to primarily vascularized allografts in miniature swine. Effect of administration of exogenous IL-2","volume":"153","author":"Gianello","year":"1994","journal-title":"J Immunol"},{"key":"10.1111\/ajt.12816_bib10","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1111\/ajt.12194","article-title":"The induction of tolerance of renal allografts by adoptive transfer in miniature swine","volume":"13","author":"Okumi","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12816_bib11","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00007890-197612000-00004","article-title":"Transplantation in miniature swine. I. Fixation of the major histocompatibility complex","volume":"22","author":"Sachs","year":"1976","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12816_bib12","first-page":"645","article-title":"Peripheral blood progenitor cell mobilization and leukapheresis in pigs","volume":"49","author":"Nash","year":"1999","journal-title":"Lab Anim Sci"},{"key":"10.1111\/ajt.12816_bib13","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1097\/00007890-199503150-00023","article-title":"Tolerance to class I disparate renal allografts in miniature swine: Maintenance of tolerance despite induction of specific antidonor CTL responses","volume":"59","author":"Gianello","year":"1995","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12816_bib14","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/TP.0b013e31815e8eed","article-title":"Role of persistence of antigen and indirect recognition in the maintenance of tolerance to renal allografts","volume":"85","author":"Okumi","year":"2008","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12816_bib15","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00007890-199701150-00006","article-title":"Molecular and cellular events implicated in local tolerance to kidney allografts in miniature swine","volume":"63","author":"Blancho","year":"1997","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12816_bib16","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1084\/jem.160.5.1495","article-title":"Effect of class II antigen matching on renal allograft survival in miniature swine","volume":"160","author":"Pescovitz","year":"1984","journal-title":"J Exp Med"},{"key":"10.1111\/ajt.12816_bib17","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/00007890-198406000-00024","article-title":"Localization of class II MHC antigens on porcine renal vascular endothelium","volume":"37","author":"Pescovitz","year":"1984","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12816_bib18","doi-asserted-by":"crossref","first-page":"368","DOI":"10.4049\/jimmunol.133.1.368","article-title":"Preparation and characterization of monoclonal antibodies reactive with porcine PBL","volume":"133","author":"Pescovitz","year":"1984","journal-title":"J Immunol"},{"key":"10.1111\/ajt.12816_bib19","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.4049\/jimmunol.181.6.4027","article-title":"Linked suppression across an MHC-mismatched barrier in a miniature swine kidney transplantation model","volume":"181","author":"Griesemer","year":"2008","journal-title":"J Immunol"},{"key":"10.1111\/ajt.12816_bib20","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1053-2498(00)00256-4","article-title":"CTLA4Ig and donor-specific transfusion prolongs cardiac allograft survival in the miniature swine","volume":"20","author":"Lee","year":"2001","journal-title":"J Heart Lung Transplant"},{"key":"10.1111\/ajt.12816_bib21","first-page":"189","article-title":"Renal transplantation in miniature swine: Preliminary evidence that graft infiltrating leukocytes suppress donor-specific cell-mediated lymphocytotoxicity in co-culture","volume":"23","author":"Rosengard","year":"1991","journal-title":"Transplant Proc"},{"key":"10.1111\/ajt.12816_bib22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0198-8859(90)90012-E","article-title":"Transplantation in miniature swine: Analysis of graft-infiltrating lymphocytes provides evidence for local suppression","volume":"28","author":"Rosengard","year":"1990","journal-title":"Hum Immunol"},{"key":"10.1111\/ajt.12816_bib23","doi-asserted-by":"crossref","first-page":"19081","DOI":"10.1073\/pnas.0605159103","article-title":"Thymic rejuvenation and the induction of tolerance by adult thymic grafts","volume":"103","author":"Nobori","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/ajt.12816_bib24","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1111\/j.1600-6143.2004.00566.x","article-title":"TGF-beta induces Foxp3+ T-regulatory cells from CD4+ C","volume":"4","author":"Fu","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.12816_bib25","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1126\/science.1214277","article-title":"Rescued tolerant CD8 T cells are preprogrammed to reestablish the tolerant state","volume":"335","author":"Schietinger","year":"2012","journal-title":"Science"},{"key":"10.1111\/ajt.12816_bib26","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1097\/00007890-199112000-00020","article-title":"The failure of skin grafting to break tolerance to class I disparate renal allografts in miniature swine despite inducing marked anti-donor cellular immunity","volume":"52","author":"Rosengard","year":"1991","journal-title":"Transplantation"},{"key":"10.1111\/ajt.12816_bib27","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S0041-1345(96)00515-5","article-title":"Preliminary in vitro evidence for regulatory cells in a miniature swine renal allograft model","volume":"29","author":"Ierino","year":"1997","journal-title":"Transplant Proc"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.12816","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522255889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522255889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:04:17Z","timestamp":1761627857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522255889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S1600613522255889"],"URL":"https:\/\/doi.org\/10.1111\/ajt.12816","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Abrogation of Renal Allograft Tolerance in MGH Miniature Swine: The Role of Intra-Graft and Peripheral Factors in Long-Term Tolerance","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.12816","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}