{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:09:20Z","timestamp":1791212960452,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":2792,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NIH","award":["R01AI097361"],"award-info":[{"award-number":["R01AI097361"]}]},{"name":"NIH","award":["R01AI091977"],"award-info":[{"award-number":["R01AI091977"]}]},{"name":"NIH","award":["R56AI101150"],"award-info":[{"award-number":["R56AI101150"]}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1111\/ajt.13087","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T22:45:12Z","timestamp":1422917112000},"page":"942-953","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"title":["TIM-1 Signaling Is Required for Maintenance and Induction of Regulatory B Cells"],"prefix":"10.1016","volume":"15","author":[{"given":"M.Y.","family":"Yeung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.R.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.J.","family":"Workman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.A.A.","family":"Vignali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.F.","family":"Padera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.K.","family":"Kuchroo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Najafian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.M.","family":"Rothstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/ajt.13087_bib1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1749-6632.2009.05137.x","article-title":"B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer","volume":"1183","author":"DiLillo","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1111\/ajt.13087_bib2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev-immunol-020711-074934","article-title":"Immune regulatory function of B cells","volume":"30","author":"Mauri","year":"2012","journal-title":"Annu Rev Immunol"},{"key":"10.1111\/ajt.13087_bib3","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.immuni.2008.03.017","article-title":"A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses","volume":"28","author":"Yanaba","year":"2008","journal-title":"Immunity"},{"key":"10.1111\/ajt.13087_bib4","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/ni833","article-title":"B cells regulate autoimmunity by provision of IL-10","volume":"3","author":"Fillatreau","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1111\/ajt.13087_bib5","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1172\/JCI46274","article-title":"Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice","volume":"121","author":"Ding","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1111\/ajt.13087_bib6","doi-asserted-by":"crossref","first-page":"14080","DOI":"10.1073\/pnas.0700326104","article-title":"Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells","volume":"104","author":"Gray","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/ajt.13087_bib7","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1073\/pnas.1109173109","article-title":"A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells","volume":"109","author":"Miles","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/ajt.13087_bib8","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nature12979","article-title":"IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases","volume":"507","author":"Shen","year":"2014","journal-title":"Nature"},{"key":"10.1111\/ajt.13087_bib9","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1172\/JCI34487","article-title":"Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells","volume":"118","author":"Ichimura","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1111\/ajt.13087_bib10","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.immuni.2007.11.011","article-title":"TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells","volume":"27","author":"Kobayashi","year":"2007","journal-title":"Immunity"},{"key":"10.1111\/ajt.13087_bib11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.immuni.2007.01.014","article-title":"Structures of T cell immunoglobulin mucin receptors 1 and 2 reveal mechanisms for regulation of immune responses by the TIM receptor family","volume":"26","author":"Santiago","year":"2007","journal-title":"Immunity"},{"key":"10.1111\/ajt.13087_bib12","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nri2366","article-title":"New roles for TIM family members in immune regulation","volume":"8","author":"Kuchroo","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1111\/ajt.13087_bib13","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.0105-2896.2010.00903.x","article-title":"TIM genes: A family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity","volume":"235","author":"Freeman","year":"2010","journal-title":"Immunol Rev"},{"key":"10.1111\/ajt.13087_bib14","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1172\/JCI32562","article-title":"Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice","volume":"118","author":"Degauque","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1111\/ajt.13087_bib15","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1084\/jem.20062498","article-title":"Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function","volume":"204","author":"Xiao","year":"2007","journal-title":"J Exp Med"},{"key":"10.1111\/ajt.13087_bib16","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1172\/JCI32451","article-title":"The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model","volume":"118","author":"Ueno","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1111\/ajt.13087_bib17","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/ni739","article-title":"Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family","volume":"2","author":"McIntire","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1111\/ajt.13087_bib18","doi-asserted-by":"crossref","first-page":"12105","DOI":"10.1073\/pnas.1120914109","article-title":"Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice","volume":"109","author":"Xiao","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/ajt.13087_bib19","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.immuni.2014.03.004","article-title":"TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity","volume":"40","author":"Angiari","year":"2014","journal-title":"Immunity"},{"key":"10.1111\/ajt.13087_bib20","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1681\/ASN.2011070646","article-title":"Orphan nuclear receptor Nur77 promotes acute kidney injury and renal epithelial apoptosis","volume":"23","author":"Balasubramanian","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/ajt.13087_bib21","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.cub.2009.01.042","article-title":"The phosphatidylserine receptor TIM-4 does not mediate direct signaling","volume":"19","author":"Park","year":"2009","journal-title":"Curr Biol"},{"key":"10.1111\/ajt.13087_bib22","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1128\/MCB.05993-11","article-title":"Two-step engulfment of apoptotic cells","volume":"32","author":"Toda","year":"2012","journal-title":"Mol Cell Biol"},{"key":"10.1111\/ajt.13087_bib23","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1034\/j.1600-6143.2003.00062.x","article-title":"Allograft rejection in a new allospecific CD4+ TCR transgenic mouse","volume":"3","author":"Sayegh","year":"2003","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.13087_bib24","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.4049\/jimmunol.169.7.3744","article-title":"Physiological mechanisms of regulating alloimmunity: Cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size","volume":"169","author":"Sho","year":"2002","journal-title":"J Immunol"},{"key":"10.1111\/ajt.13087_bib25","doi-asserted-by":"crossref","first-page":"a008748","DOI":"10.1101\/cshperspect.a008748","article-title":"Clearing the dead: Apoptotic cell sensing, recognition, engulfment, and digestion","volume":"5","author":"Hochreiter-Hufford","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1111\/ajt.13087_bib26","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.cell.2010.02.014","article-title":"Autoimmunity and the clearance of dead cells","volume":"140","author":"Nagata","year":"2010","journal-title":"Cell"},{"key":"10.1111\/ajt.13087_bib27","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/nri2214","article-title":"Engulfment of apoptotic cells: signals for a good meal","volume":"7","author":"Ravichandran","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1111\/ajt.13087_bib28","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.4049\/jimmunol.1003021","article-title":"Natural IgM is required for suppression of inflammatory arthritis by apoptotic cells","volume":"186","author":"Notley","year":"2011","journal-title":"J Immunol"},{"key":"10.1111\/ajt.13087_bib29","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nm.3554","article-title":"Interleukin-35 induces regulatory B cells that suppress autoimmune disease","volume":"20","author":"Wang","year":"2014","journal-title":"Nat Med"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.13087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.13087","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S160061352200168X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S160061352200168X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/ajt.13087\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:09:52Z","timestamp":1761628192000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S160061352200168X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S160061352200168X"],"URL":"https:\/\/doi.org\/10.1111\/ajt.13087","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TIM-1 Signaling Is Required for Maintenance and Induction of Regulatory B Cells","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.13087","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}