{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:38:17Z","timestamp":1791308297691,"version":"4.3.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":2439,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 A1097423"],"award-info":[{"award-number":["R01 A1097423"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1111\/ajt.13613","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T00:24:50Z","timestamp":1448411090000},"page":"1102-1112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":113,"title":["CD57+ CD4 T Cells Underlie Belatacept-Resistant Allograft Rejection"],"prefix":"10.1016","volume":"16","author":[{"given":"J.","family":"Espinosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Herr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Tharp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bosinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"A.B.","family":"Farris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Cheeseman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Stempora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Townsend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Durrbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.D.","family":"Kirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1111\/ajt.13613_bib1","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1182\/blood.V92.5.1549.417k32_1549_1555","article-title":"Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients","volume":"92","author":"Rooney","year":"1998","journal-title":"Blood"},{"issue":"5","key":"10.1111\/ajt.13613_bib2","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1182\/blood-2009-08-239186","article-title":"Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients","volume":"115","author":"Heslop","year":"2010","journal-title":"Blood"},{"issue":"3","key":"10.1111\/ajt.13613_bib3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1399-3062.2009.00372.x","article-title":"Cytomegalovirus infection and disease in the new era of immunosuppression following solid organ transplantation","volume":"11","author":"Fisher","year":"2009","journal-title":"Transpl Infect Dis"},{"issue":"2","key":"10.1111\/ajt.13613_bib4","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/ajt.12574","article-title":"The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation","volume":"14","author":"Xu","year":"2014","journal-title":"Am J Transplant"},{"issue":"1","key":"10.1111\/ajt.13613_bib5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/00000478-199301000-00007","article-title":"The histopathological changes associated with allograft rejection and drug toxicity in renal transplant recipients maintained on FK506. Clinical significance and comparison with cyclosporine","volume":"17","author":"Randhawa","year":"1993","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10.1111\/ajt.13613_bib6","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2215\/CJN.04800908","article-title":"Calcineurin inhibitor nephrotoxicity","volume":"4","author":"Naesens","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"issue":"5 Pt 1","key":"10.1111\/ajt.13613_bib7","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/j.1600-6143.2006.01259.x","article-title":"A new look at blockade of T-cell costimulation: A therapeutic strategy for long-term maintenance immunosuppression","volume":"6","author":"Larsen","year":"2006","journal-title":"Am J Transplant"},{"issue":"3","key":"10.1111\/ajt.13613_bib8","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1600-6143.2009.03005.x","article-title":"A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study)","volume":"10","author":"Vincenti","year":"2010","journal-title":"Am J Transplant"},{"issue":"1","key":"10.1111\/ajt.13613_bib9","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1600-6143.2011.03785.x","article-title":"Three-year outcomes from BENEFIT, a randomized, active-controlled, parallel-group study in adult kidney transplant recipients","volume":"12","author":"Vincenti","year":"2012","journal-title":"Am J Transplant"},{"issue":"11","key":"10.1111\/ajt.13613_bib10","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1111\/ajt.12460","article-title":"Long-term belatacept exposure maintains efficacy and safety at 5 years: Results from the long-term extension of the BENEFIT study","volume":"13","author":"Rostaing","year":"2013","journal-title":"Am J Transplant"},{"issue":"6","key":"10.1111\/ajt.13613_bib11","doi-asserted-by":"crossref","first-page":"807","DOI":"10.2144\/000112761","article-title":"A quantitative real-time PCR method for absolute telomere length","volume":"44","author":"O\u2019Callaghan","year":"2008","journal-title":"Biotechniques"},{"issue":"3","key":"10.1111\/ajt.13613_bib12","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1093\/nar\/gkn1027","article-title":"Telomere length measurement by a novel monochrome multiplex quantitative PCR method","volume":"37","author":"Cawthon","year":"2009","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"10.1111\/ajt.13613_bib13","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1084\/jem.186.9.1407","article-title":"Phenotypic and functional separation of memory and effector human CD8+ T cells","volume":"186","author":"Hamann","year":"1997","journal-title":"J Exp Med"},{"issue":"10","key":"10.1111\/ajt.13613_bib14","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.4049\/jimmunol.141.10.3249","article-title":"Differential activation requirements for virgin and memory T cells","volume":"141","author":"Byrne","year":"1988","journal-title":"J Immunol"},{"issue":"7","key":"10.1111\/ajt.13613_bib15","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/nm.1993","article-title":"Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates","volume":"15","author":"Weaver","year":"2009","journal-title":"Nat Med"},{"issue":"1","key":"10.1111\/ajt.13613_bib16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1600-6143.2010.03317.x","article-title":"Selective targeting of human alloresponsive CD8+ effector memory T cells based on CD2 expression","volume":"11","author":"Lo","year":"2011","journal-title":"Am J Transplant"},{"issue":"10","key":"10.1111\/ajt.13613_bib17","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1097\/TP.0b013e31824e75d7","article-title":"Combined costimulatory and leukocyte functional antigen-1 blockade prevents transplant rejection mediated by heterologous immune memory alloresponses","volume":"93","author":"Kitchens","year":"2012","journal-title":"Transplantation"},{"issue":"6","key":"10.1111\/ajt.13613_bib18","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ni.2035","article-title":"T cell exhaustion","volume":"12","author":"Wherry","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1111\/ajt.13613_bib19","first-page":"17","article-title":"Role of PD-1 in regulating T-cell immunity","volume":"350","author":"Jin","year":"2011","journal-title":"Curr Top Microbiol Immunol"},{"issue":"7","key":"10.1111\/ajt.13613_bib20","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1182\/blood-2002-07-2103","article-title":"Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells","volume":"101","author":"Brenchley","year":"2003","journal-title":"Blood"},{"issue":"2","key":"10.1111\/ajt.13613_bib21","doi-asserted-by":"crossref","first-page":"E20","DOI":"10.1371\/journal.pbio.0020020","article-title":"Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection","volume":"2","author":"Papagno","year":"2004","journal-title":"PLoS Biol"},{"issue":"6","key":"10.1111\/ajt.13613_bib22","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/jb\/mvm221","article-title":"Expression and function of the HNK-1 carbohydrate","volume":"143","author":"Morita","year":"2008","journal-title":"J Biochem"},{"issue":"12","key":"10.1111\/ajt.13613_bib23","doi-asserted-by":"crossref","first-page":"8415","DOI":"10.4049\/jimmunol.175.12.8415","article-title":"Functional and phenotypic characterization of CD57+CD4+ T cells and their association with HIV-1-induced T cell dysfunction","volume":"175","author":"Palmer","year":"2005","journal-title":"J Immunol"},{"issue":"1","key":"10.1111\/ajt.13613_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-2567.2011.03470.x","article-title":"CD8+ CD28- and CD8+ CD57+ T cells and their role in health and disease","volume":"134","author":"Strioga","year":"2011","journal-title":"Immunology"},{"issue":"1","key":"10.1111\/ajt.13613_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1189\/jlb.0809566","article-title":"CD57+ T lymphocytes and functional immune deficiency","volume":"87","author":"Focosi","year":"2010","journal-title":"J Leukoc Biol"},{"issue":"8","key":"10.1111\/ajt.13613_bib26","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1158\/0008-5472.CAN-09-4595","article-title":"Telomere length in prospective and retrospective cancer case-control studies","volume":"70","author":"Pooley","year":"2010","journal-title":"Cancer Res"},{"issue":"3","key":"10.1111\/ajt.13613_bib27","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9","article-title":"The Ki-67 protein: From the known and the unknown","volume":"182","author":"Scholzen","year":"2000","journal-title":"J Cell Physiol"},{"issue":"12","key":"10.1111\/ajt.13613_bib28","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.1172\/JCI43895","article-title":"LFA-1-specific therapy prolongs allograft survival in rhesus macaques","volume":"120","author":"Badell","year":"2010","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1111\/ajt.13613_bib29","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1111\/ajt.12719","article-title":"IL-15 induces alloreactive CD28(-) memory CD8 T cell proliferation and CTLA4-Ig resistant memory CD8 T cell activation","volume":"14","author":"Traitanon","year":"2014","journal-title":"Am J Transplant"},{"issue":"2","key":"10.1111\/ajt.13613_bib30","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jss.2015.02.033","article-title":"Viral-induced CD28 loss evokes costimulation independent alloimmunity","volume":"196","author":"Mou","year":"2015","journal-title":"J Surg Res"},{"issue":"25","key":"10.1111\/ajt.13613_bib31","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1056\/NEJM199806183382506","article-title":"The role of T-cell costimulatory activation pathways in transplant rejection","volume":"338","author":"Sayegh","year":"1998","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1111\/ajt.13613_bib32","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/nrneph.2013.183","article-title":"Targeting co-stimulatory pathways: Transplantation and autoimmunity","volume":"10","author":"Ford","year":"2014","journal-title":"Nat Rev Nephrol"},{"issue":"5","key":"10.1111\/ajt.13613_bib33","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.smim.2004.08.013","article-title":"Generation and maintenance of immunological memory","volume":"16","author":"Gourley","year":"2004","journal-title":"Semin Immunol"},{"issue":"5258","key":"10.1111\/ajt.13613_bib34","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1126\/science.272.5258.54","article-title":"Immunological memory and protective immunity: Understanding their relation","volume":"272","author":"Ahmed","year":"1996","journal-title":"Science"},{"issue":"6","key":"10.1111\/ajt.13613_bib35","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1155\/2011\/217860","article-title":"Immunosenescent CD57+CD4+ T-cells accumulate and contribute to interferon-gamma responses in HIV patients responding stably to ART","volume":"31","author":"Fernandez","year":"2011","journal-title":"Dis Markers"},{"issue":"2","key":"10.1111\/ajt.13613_bib36","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.4049\/jimmunol.135.2.1061","article-title":"Two-color immunofluorescence and flow cytometry analysis of lymphocytes in long-term renal allotransplant recipients: Identification of a major Leu-7+\/Leu-3+ subpopulation","volume":"135","author":"Legendre","year":"1985","journal-title":"J Immunol"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.13613","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522008760?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522008760?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:10:28Z","timestamp":1761628228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522008760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S1600613522008760"],"URL":"https:\/\/doi.org\/10.1111\/ajt.13613","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD57+ CD4 T Cells Underlie Belatacept-Resistant Allograft Rejection","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.13613","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}