{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:43:24Z","timestamp":1790757804259,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":2351,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Regione Lombardia, Programma Ricerca Trapianti"},{"name":"IRCCS Policlinico San Matteo, progetti Ricerca Corrente"},{"name":"Istituto G. Gaslini, progetti Ricerca Corrente"},{"name":"Fondazione La Nuova Speranza Onlus"},{"name":"Fondazione Malattie Renali del Bambino, Genova"}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1111\/ajt.13700","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T04:50:41Z","timestamp":1451883041000},"page":"2106-2116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"title":["Acquisition of C3d\u2010Binding Activity by De Novo Donor\u2010Specific HLA Antibodies Correlates With Graft Loss in Nonsensitized Pediatric Kidney Recipients"],"prefix":"10.1016","volume":"16","author":[{"given":"P.","family":"Comoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tagliamacco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Quartuccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Innocente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Trivelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Magnasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Klersy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Rubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ramondetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zecca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Garibotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.M.","family":"Ghiggeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cardillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nocera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ginevri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1111\/ajt.13700_bib1","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1111\/j.1600-6143.2011.03640.x","article-title":"Revisiting traditional risk factors for rejection and graft loss after kidney transplantation","volume":"11","author":"Dunn","year":"2011","journal-title":"Am J Transplant"},{"issue":"4","key":"10.1111\/ajt.13700_bib2","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/TP.0b013e3181b11b72","article-title":"HLA-specific antibodies developed in the first year posttransplant are predictive of chronic rejection and renal graft loss","volume":"88","author":"Lee","year":"2009","journal-title":"Transplantation"},{"issue":"11","key":"10.1111\/ajt.13700_bib3","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1111\/j.1600-6143.2009.02800.x","article-title":"De novo donor-specific antibody at the time of kidney transplant biopsy associates with microvascular pathology and late graft failure","volume":"9","author":"Hidalgo","year":"2009","journal-title":"Am J Transplant"},{"issue":"1","key":"10.1111\/ajt.13700_bib4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/TP.0b013e3181e065de","article-title":"Evidence for antibody-mediated injury as a major determinant of late kidney allograft failure","volume":"90","author":"Gaston","year":"2010","journal-title":"Transplantation"},{"issue":"8","key":"10.1111\/ajt.13700_bib5","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1681\/ASN.2009101065","article-title":"Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation","volume":"21","author":"Lefaucheur","year":"2010","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"10.1111\/ajt.13700_bib6","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1600-6143.2011.03840.x","article-title":"Understanding the causes of kidney transplant failure: The dominant role of antibody-mediated rejection and nonadherence","volume":"12","author":"Sellares","year":"2012","journal-title":"Am J Transplant"},{"issue":"8","key":"10.1111\/ajt.13700_bib7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.humimm.2009.04.013","article-title":"Presensitized kidney graft recipients with HLA class I and II antibodies are at increased risk for graft failure: A Collaborative Transplant Study report","volume":"70","author":"Susal","year":"2009","journal-title":"Hum Immunol"},{"issue":"12","key":"10.1111\/ajt.13700_bib8","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1111\/j.1600-6143.2008.02441.x","article-title":"Alloantibody levels and acute humoral rejection early after positive crossmatch kidney transplantation","volume":"8","author":"Burns","year":"2008","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.13700_bib9","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/ki.2015.205","article-title":"Preformed circulating HLA-specific memory B cells predict high risk of humoral rejection in kidney transplantation","volume":"88","author":"Lucia","year":"2015","journal-title":"Kidney Int"},{"issue":"5","key":"10.1111\/ajt.13700_bib10","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1600-6143.2012.04013.x","article-title":"Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant","volume":"12","author":"Wiebe","year":"2012","journal-title":"Am J Transplant"},{"issue":"12","key":"10.1111\/ajt.13700_bib11","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1111\/j.1600-6143.2012.04251.x","article-title":"Posttransplant de novo donor-specific HLA antibodies identify pediatric kidney recipients at risk for late antibody-mediated rejection","volume":"12","author":"Ginevri","year":"2012","journal-title":"Am J Transplant"},{"issue":"3","key":"10.1111\/ajt.13700_bib12","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/TP.0b013e31827d62e3","article-title":"Incidence and impact of de novo donor-specific alloantibody in primary renal allografts","volume":"95","author":"Everly","year":"2013","journal-title":"Transplantation"},{"issue":"1","key":"10.1111\/ajt.13700_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/TP.0b013e31827a19cc","article-title":"Consensus guidelines on the testing and clinical management issues associated with HLA and non-HLA antibodies in transplantation","volume":"95","author":"Tait","year":"2013","journal-title":"Transplantation"},{"issue":"5","key":"10.1111\/ajt.13700_bib14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.molmed.2015.02.004","article-title":"The perfect storm: HLA antibodies, complement, FcgammaRs, and endothelium in transplant rejection","volume":"21","author":"Thomas","year":"2015","journal-title":"Trends Mol Med"},{"issue":"10","key":"10.1111\/ajt.13700_bib15","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.humimm.2011.07.001","article-title":"Novel C1q assay reveals a clinically relevant subset of human leukocyte antigen antibodies independent of immunoglobulin G strength on single antigen beads","volume":"72","author":"Chen","year":"2011","journal-title":"Hum Immunol"},{"issue":"9","key":"10.1111\/ajt.13700_bib16","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1097\/TP.0b013e3182888db6","article-title":"The role of immunoglobulin-G subclasses and C1q in de novo HLA-DQ donor-specific antibody kidney transplantation outcomes","volume":"95","author":"Freitas","year":"2013","journal-title":"Transplantation"},{"issue":"3","key":"10.1111\/ajt.13700_bib17","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/TP.0b013e318203fd26","article-title":"C1q-fixing human leukocyte antigen antibodies are specific for predicting transplant glomerulopathy and late graft failure after kidney transplantation","volume":"91","author":"Yabu","year":"2011","journal-title":"Transplantation"},{"issue":"1","key":"10.1111\/ajt.13700_bib18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1399-3046.2011.01599.x","article-title":"Complement-fixing donor-specific antibodies identified by a novel C1q assay are associated with allograft loss","volume":"16","author":"Sutherland","year":"2012","journal-title":"Pediatr Transplant"},{"issue":"13","key":"10.1111\/ajt.13700_bib19","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1056\/NEJMoa1302506","article-title":"Complement-binding anti-HLA antibodies and kidney-allograft survival","volume":"369","author":"Loupy","year":"2013","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1111\/ajt.13700_bib20","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1681\/ASN.2014040326","article-title":"Non-complement-binding de novo donor-specific anti-hla antibodies and kidney allograft survival","volume":"27","author":"Guidicelli","year":"2016","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"10.1111\/ajt.13700_bib21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1681\/ASN.2013101144","article-title":"Detection of C3d-binding donor-specific anti-HLA antibodies at diagnosis of humoral rejection predicts renal graft loss","volume":"26","author":"Sicard","year":"2015","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"10.1111\/ajt.13700_bib22","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1681\/ASN.2008030287","article-title":"New equations to estimate GFR in children with CKD","volume":"20","author":"Schwartz","year":"2009","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"10.1111\/ajt.13700_bib23","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1053\/j.ajkd.2014.01.436","article-title":"Performance of creatinine-based GFR estimating equations in solid-organ transplant recipients","volume":"63","author":"Shaffi","year":"2014","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"10.1111\/ajt.13700_bib24","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1600-6143.2009.02987.x","article-title":"Banff \u201809 meeting report: Antibody mediated graft deterioration and implementation of Banff working groups","volume":"10","author":"Sis","year":"2010","journal-title":"Am J Transplant"},{"issue":"2","key":"10.1111\/ajt.13700_bib25","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/ajt.12590","article-title":"Banff 2013 meeting report: Inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions","volume":"14","author":"Haas","year":"2014","journal-title":"Am J Transplant"},{"issue":"7","key":"10.1111\/ajt.13700_bib26","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/tri.12316","article-title":"DQ molecules are the principal stimulators of de novo donor-specific antibodies in nonsensitized pediatric recipients receiving a first kidney transplant","volume":"27","author":"Tagliamacco","year":"2014","journal-title":"Transpl Int"},{"issue":"6","key":"10.1111\/ajt.13700_bib27","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/TP.0000000000000315","article-title":"Deciphering complement interference in anti-human leukocyte antigen antibody detection with flow beads assays","volume":"98","author":"Visentin","year":"2014","journal-title":"Transplantation"},{"issue":"2","key":"10.1111\/ajt.13700_bib28","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/0049124104268644","article-title":"Multimodel inference\u2014understanding AIC and BIC in model selection","volume":"33","author":"Burnham","year":"2004","journal-title":"Sociol Methods Res"},{"issue":"11","key":"10.1111\/ajt.13700_bib29","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nrneph.2012.212","article-title":"The role of complement in antibody-mediated rejection in kidney transplantation","volume":"8","author":"Stegall","year":"2012","journal-title":"Nat Rev Nephrol"},{"issue":"6","key":"10.1111\/ajt.13700_bib30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.humimm.2012.04.016","article-title":"Cutoff values and data handling for solid-phase testing for antibodies to HLA: Effects on listing unacceptable antigens for thoracic organ transplantation","volume":"73","author":"Liu","year":"2012","journal-title":"Hum Immunol"},{"issue":"2","key":"10.1111\/ajt.13700_bib31","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1600-6143.2011.03836.x","article-title":"A novel pathway of chronic allograft rejection mediated by NK cells and alloantibody","volume":"12","author":"Hirohashi","year":"2012","journal-title":"Am J Transplant"},{"issue":"8","key":"10.1111\/ajt.13700_bib32","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1111\/j.1600-6143.2010.03201.x","article-title":"NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: Evidence for NK cell involvement in antibody-mediated rejection","volume":"10","author":"Hidalgo","year":"2010","journal-title":"Am J Transplant"},{"issue":"11","key":"10.1111\/ajt.13700_bib33","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1111\/j.1600-6143.2009.02819.x","article-title":"Effect of antibodies on endothelium","volume":"9","author":"Zhang","year":"2009","journal-title":"Am J Transplant"},{"issue":"10","key":"10.1111\/ajt.13700_bib34","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1097\/TP.0000000000000190","article-title":"Changes in successive measures of de novo donor-specific anti-human leukocyte antigen antibodies intensity and the development of allograft dysfunction","volume":"98","author":"Dieplinger","year":"2014","journal-title":"Transplantation"},{"issue":"6","key":"10.1111\/ajt.13700_bib35","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1097\/TP.0000000000000699","article-title":"C1q binding activity of de novo donor-specific HLA antibodies in renal transplant recipients with and without antibody-mediated rejection","volume":"99","author":"Yell","year":"2015","journal-title":"Transplantation"},{"issue":"1","key":"10.1111\/ajt.13700_bib36","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.healun.2012.09.021","article-title":"Persistent strong anti-HLA antibody at high titer is complement binding and associated with increased risk of antibody-mediated rejection in heart transplant recipients","volume":"32","author":"Zeevi","year":"2013","journal-title":"J Heart Lung Transplant"},{"key":"10.1111\/ajt.13700_bib37","doi-asserted-by":"crossref","unstructured":"Bohmig GA, Kikic Z, Wahrmann M, et al. Detection of alloantibody-mediated complement activation: a diagnostic advance in monitoring kidney transplant rejection? Clin Biochem 2015; doi: 10.1016\/j.clinbiochem.2015.05.024 [Epub ahead of print].","DOI":"10.1016\/j.clinbiochem.2015.05.024"},{"issue":"12","key":"10.1111\/ajt.13700_bib38","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nrneph.2013.234","article-title":"Transplantation: Complementing donor-specific antibody testing","volume":"9","author":"Tinckam","year":"2013","journal-title":"Nat Rev Nephrol"},{"key":"10.1111\/ajt.13700_bib39","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1111\/ajt.12859","article-title":"The clinical spectrum of de novo donor-specific antibodies in pediatric renal transplant recipients","volume":"14","author":"Kim","year":"2014","journal-title":"Am J Transplant"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.13700","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.13700","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522009261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522009261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/ajt.13700\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:13:27Z","timestamp":1761628407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522009261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S1600613522009261"],"URL":"https:\/\/doi.org\/10.1111\/ajt.13700","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acquisition of C3d\u2010Binding Activity by De Novo Donor\u2010Specific HLA Antibodies Correlates With Graft Loss in Nonsensitized Pediatric Kidney Recipients","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.13700","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}