{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:02:08Z","timestamp":1781200928510,"version":"3.54.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":2253,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006396","name":"Alexion Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1111\/ajt.13882","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T06:43:18Z","timestamp":1464072198000},"page":"3041-3045","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Splenic Irradiation for the Treatment of Severe Antibody-Mediated Rejection"],"prefix":"10.1016","volume":"16","author":[{"given":"B.J","family":"Orandi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.E","family":"Lonze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Terezakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.S","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Alachkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M","family":"Bagnasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.L","family":"Segev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.B","family":"Orens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.A","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/ajt.13882_bib1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1056\/NEJMoa1012376","article-title":"Desensitization in HLA-incompatible kidney recipients and survival","volume":"365","author":"Montgomery","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1111\/ajt.13882_bib2","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1056\/NEJMoa1508380","article-title":"Survival benefit with kidney transplants from HLA-incompatible live donors","volume":"374","author":"Orandi","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1111\/ajt.13882_bib3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/ajt.12982","article-title":"Quantifying renal allograft loss following early antibody-mediated rejection","volume":"15","author":"Orandi","year":"2015","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.13882_bib4","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/TP.0000000000000298","article-title":"Eculizumab and splenectomy as salvage therapy for severe antibody-mediated rejection following HLA-incompatible kidney transplantation","volume":"98","author":"Orandi","year":"2014","journal-title":"Transplantation"},{"key":"10.1111\/ajt.13882_bib5","first-page":"518","article-title":"Rescue splenectomy for severe acute antibody-mediated rejection","author":"Locke","year":"2006","journal-title":"Clin Transpl"},{"key":"10.1111\/ajt.13882_bib6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/01.tp.0000243739.31440.2b","article-title":"Successful rescue of refractory, severe antibody mediated rejection with splenectomy","volume":"83","author":"Kaplan","year":"2007","journal-title":"Transplantation"},{"key":"10.1111\/ajt.13882_bib7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1084\/jem.20031104","article-title":"Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression","volume":"199","author":"Ueda","year":"2004","journal-title":"J Exp Med"},{"key":"10.1111\/ajt.13882_bib8","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nri1203","article-title":"Plasma-cell homing","volume":"3","author":"Kunkel","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1111\/ajt.13882_bib9","unstructured":"Case Report Publication Guidance: IRB Review and HIPAA Compliance. Office of Human Subjects Research\u2013Institutional Review Board 2006[cited 2015 Dec 08]. Available from: http:\/\/www.hopkinsmedicine.org\/institutional_review_board\/guidelines_policies\/guidelines\/case_report.html."},{"key":"10.1111\/ajt.13882_bib10","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1399-3046.2004.00214.x","article-title":"Transplanting patients with a positive donor-specific crossmatch: A single center's perspective","volume":"8","author":"Montgomery","year":"2004","journal-title":"Pediatr Transplant"},{"key":"10.1111\/ajt.13882_bib11","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/ajt.12590","article-title":"Banff 2013 meeting report: Inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions","volume":"14","author":"Haas","year":"2014","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.13882_bib12","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/j.1600-6143.2006.01709.x","article-title":"The utility of splenectomy as rescue treatment for severe acute antibody mediated rejection","volume":"7","author":"Locke","year":"2007","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.13882_bib13","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/ajt.13168","article-title":"Positive crossmatch kidney transplant recipients treated with eculizumab: Outcomes beyond 1 year","volume":"15","author":"Cornell","year":"2015","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.13882_bib14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0167-8140(00)00316-9","article-title":"Clinical indications and biological mechanisms of splenic irradiation in chronic leukaemias and myeloproliferative disorders","volume":"58","author":"Weinmann","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1111\/ajt.13882_bib15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/PL00002384","article-title":"Clinical indications and biological mechanisms of splenic irradiation in autoimmune diseases","volume":"177","author":"Weinmann","year":"2001","journal-title":"Strahlenther Onkol"},{"key":"10.1111\/ajt.13882_bib16","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.2174\/092986712800099866","article-title":"Modulation of inflammatory immune reactions by low-dose ionizing radiation: Molecular mechanisms and clinical application","volume":"19","author":"Rodel","year":"2012","journal-title":"Curr Med Chem"},{"key":"10.1111\/ajt.13882_bib17","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nri3045","article-title":"Modulation of the immune system by UV radiation: More than just the effects of vitamin D?","volume":"11","author":"Hart","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1111\/ajt.13882_bib18","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1667\/RR2160.1","article-title":"Effects of low-dose radiation on the immune system of mice after total-body irradiation","volume":"174","author":"Bogdandi","year":"2010","journal-title":"Radiat Res"},{"key":"10.1111\/ajt.13882_bib19","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.ijrobp.2013.05.029","article-title":"Adjuvant and salvage radiation therapy after prostatectomy: American Society for Radiation Oncology\/American Urological Association guidelines","volume":"86","author":"Valicenti","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1111\/ajt.13882_bib20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ijrobp.2010.04.042","article-title":"Fractionation for whole breast irradiation: An American Society for Radiation Oncology (ASTRO) evidence-based guideline","volume":"81","author":"Smith","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.13882","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522007389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522007389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:14:05Z","timestamp":1761628445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522007389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S1600613522007389"],"URL":"https:\/\/doi.org\/10.1111\/ajt.13882","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Splenic Irradiation for the Treatment of Severe Antibody-Mediated Rejection","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.13882","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}