{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:04:23Z","timestamp":1783688663131,"version":"3.55.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"vor","delay-in-days":1967,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1111\/ajt.14226","type":"journal-article","created":{"date-parts":[[2017,2,11]],"date-time":"2017-02-11T03:02:36Z","timestamp":1486782156000},"page":"1941-1944","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Hemoglobin-Based Oxygen Carrier Rescues Double-Transplant Patient From Life-Threatening Anemia"],"prefix":"10.1016","volume":"17","author":[{"given":"M.F.","family":"Gomez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Aljure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ciancio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/ajt.14226_bib1","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1111\/trf.12565","article-title":"An update on mortality and morbidity in patients with very low postoperative hemoglobin levels who decline blood transfusion (CME)","volume":"54","author":"Shander","year":"2014","journal-title":"Transfusion"},{"key":"10.1111\/ajt.14226_bib2","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1213\/ANE.0000000000000305","article-title":"A safety and efficacy evaluation of hemoglobin-based oxygen carrier HBOC-201 in a randomized, multicenter red blood cell controlled trial in noncardiac surgery patients","volume":"119","author":"Van Hemelrijck","year":"2014","journal-title":"Anest Analg"},{"key":"10.1111\/ajt.14226_bib3","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1213\/ANE.0b013e3181cd473b","article-title":"When blood is not an option: Factors affecting survival after the use of a hemoglobin-based oxygen carrier in 54 patients with life-threatening anemia","volume":"110","author":"Mackenzie","year":"2010","journal-title":"Anest Analg"},{"key":"10.1111\/ajt.14226_bib4","first-page":"1484","article-title":"HBOC-201 as an alternative to blood transfusion: Efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery","volume":"64","author":"Jahr","year":"2008","journal-title":"J Trauma"},{"key":"10.1111\/ajt.14226_bib5","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1213\/01.ANE.0000136477.46472.EB","article-title":"The effect of hemopure on coagulation in clinically relevant concentrations","volume":"99","author":"James","year":"2004","journal-title":"Anest Analg"},{"key":"10.1111\/ajt.14226_bib6","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1046\/j.1537-2995.2002.00123.x","article-title":"Mortality and morbidity in patients with very low postoperative Hb levels who decline blood transfusion","volume":"42","author":"Carson","year":"2002","journal-title":"Transfusion"},{"key":"10.1111\/ajt.14226_bib7","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1111\/j.1537-2995.2010.02603.x","article-title":"Management of acute anemia in a Jehovah\u2019s witness patient with acute lymphoblastic leukemia with polymerized bovine hemoglobin-based oxygen carrier: A case report and review of literature","volume":"50","author":"Donahue","year":"2010","journal-title":"Transfusion"},{"key":"10.1111\/ajt.14226_bib8","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1097\/00000539-200106000-00010","article-title":"The successful use of hemoglobin-based oxygen carrier as a primary blood substitute during abdominal aneurysm repair with large blood loss","volume":"92","author":"Sprung","year":"2001","journal-title":"Anest Analg"},{"key":"10.1111\/ajt.14226_bib9","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1111\/j.1537-2995.2007.01435.x","article-title":"Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled hemorrhage with prolonged delayed definitive care","volume":"47","author":"Arnaud","year":"2007","journal-title":"Transfusion"},{"key":"10.1111\/ajt.14226_bib10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1177\/0897190012451928","article-title":"Bovine hemoglobin: A nontraditional approach to the management of acute anemia in a Jehovah\u2019s Witness patient with autoimmune hemolytic anemia","volume":"26","author":"Jordan","year":"2013","journal-title":"J Pharm Pract"},{"key":"10.1111\/ajt.14226_bib11","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/01.shk.0000170354.18437.2f","article-title":"Effects of bovine polymerized hemoglobin on coagulation in controlled hemorrhagic shock in swine","volume":"24","author":"Arnaud","year":"2005","journal-title":"Shock"},{"key":"10.1111\/ajt.14226_bib12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/SHK.0b013e3181778dc3","article-title":"Resuscitation with the hemoglobin-based oxygen carrier, HBOC-201, in a swine model of severe uncontrolled hemorrhage and traumatic brain injury","volume":"31","author":"Stern","year":"2009","journal-title":"Shock"},{"key":"10.1111\/ajt.14226_bib13","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1097\/00005373-200106000-00015","article-title":"Hypotensive resuscitation using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) leads to reversal of anaerobic metabolism","volume":"50","author":"McNeil","year":"2001","journal-title":"J Trauma"},{"key":"10.1111\/ajt.14226_bib14","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/01.ta.0000219730.71206.3a","article-title":"Prehospital HBOC-201 after traumatic brain injury and hemorrhagic shock in swine","volume":"61","author":"Patel","year":"2006","journal-title":"J Trauma"},{"key":"10.1111\/ajt.14226_bib15","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jclinane.2008.05.012","article-title":"Management of hemorrhagic shock when blood is not an option","volume":"20","author":"Mackenzie","year":"2008","journal-title":"J Clin Anesth"},{"key":"10.1111\/ajt.14226_bib16","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1423-0410.2011.01573.x","article-title":"Clinical benefits and cost-effectiveness of allogeneic red-blood-cell transfusion in severe symptomatic anaemia","volume":"103","author":"Beliaev","year":"2012","journal-title":"Vox Sang"},{"key":"10.1111\/ajt.14226_bib17","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1007\/BF03022050","article-title":"Enhanced central organ oxygenation after application of bovine cell-free hemoglobin HBOC-201","volume":"52","author":"Freitag","year":"2005","journal-title":"Can J Anaesth"},{"key":"10.1111\/ajt.14226_bib18","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/0026-2862(81)90099-6","article-title":"Oxygen gradients between red blood cells in the microcirculation","volume":"22","author":"Homer","year":"1981","journal-title":"Microvasc Res"},{"key":"10.1111\/ajt.14226_bib19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0300-9572(02)00053-9","article-title":"HBOC-201 improves survival in a swine model of hemorrhagic shock and liver injury","volume":"54","author":"Katz","year":"2002","journal-title":"Resuscitation"},{"key":"10.1111\/ajt.14226_bib20","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1001\/jama.299.19.jrv80007","article-title":"Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death","volume":"299","author":"Natanson","year":"2008","journal-title":"J Am Med Assoc"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.14226","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522250679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522250679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/ajt.14226\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:16:26Z","timestamp":1761628586000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522250679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S1600613522250679"],"URL":"https:\/\/doi.org\/10.1111\/ajt.14226","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hemoglobin-Based Oxygen Carrier Rescues Double-Transplant Patient From Life-Threatening Anemia","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.14226","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}