{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:39:37Z","timestamp":1792291177618,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":1877,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C3417"],"award-info":[{"award-number":["HI14C3417"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102015R1A1A3A04000946"],"award-info":[{"award-number":["NRF\u20102015R1A1A3A04000946"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1111\/ajt.14316","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T05:23:11Z","timestamp":1492579391000},"page":"2601-2616","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Effect of Empagliflozin on Tacrolimus-Induced Pancreas Islet Dysfunction and Renal Injury"],"prefix":"10.1016","volume":"17","author":[{"given":"J.","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.W.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.H.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.W.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/ajt.14316_bib1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.47102\/annals-acadmedsg.V40N4p160","article-title":"Incidence and risk factors for development of new-onset diabetes after kidney transplantation","volume":"40","author":"Bee","year":"2011","journal-title":"Ann Acad Med Singapore"},{"key":"10.1111\/ajt.14316_bib2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2215\/CJN.01471005","article-title":"Hypoadiponectinemia is associated with insulin resistance and glucose intolerance after renal transplantation: Impact of immunosuppressive and antihypertensive drug therapy","volume":"1","author":"Hjelmesaeth","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1111\/ajt.14316_bib3","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1111\/j.1523-1755.2002.kid582.x","article-title":"Patient survival after renal transplantation: IV. Impact of post-transplant diabetes","volume":"62","author":"Cosio","year":"2002","journal-title":"Kidney Int"},{"key":"10.1111\/ajt.14316_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0272-6386(99)70101-0","article-title":"Risk for posttransplant diabetes mellitus with current immunosuppressive medications","volume":"34","author":"Weir","year":"1999","journal-title":"Am J Kidney Dis"},{"key":"10.1111\/ajt.14316_bib5","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1034\/j.1600-6143.2003.00010.x","article-title":"Diabetes mellitus after kidney transplantation in the United States","volume":"3","author":"Kasiske","year":"2003","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.14316_bib6","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1097\/00007890-199312000-00039","article-title":"Effects of FK506 and cyclosporine on dynamic insulin secretion from isolated dog pancreatic islets","volume":"56","author":"Ishizuka","year":"1993","journal-title":"Transplantation"},{"key":"10.1111\/ajt.14316_bib7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/TP.0000000000000146","article-title":"Combined treatment of tacrolimus and everolimus increases oxidative stress by pharmacological interactions","volume":"98","author":"Piao","year":"2014","journal-title":"Transplantation"},{"issue":"Suppl 3","key":"10.1111\/ajt.14316_bib8","first-page":"S1","article-title":"KDIGO clinical practice guideline for the care of kidney transplant recipients","volume":"9","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.14316_bib9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1463-1326.2011.01517.x","article-title":"Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: Characterisation and comparison with other SGLT-2 inhibitors","volume":"14","author":"Grempler","year":"2012","journal-title":"Diabetes Obes Metab"},{"key":"10.1111\/ajt.14316_bib10","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1038\/ki.2010.509","article-title":"Glucose handling by the kidney","author":"Mather","year":"2011","journal-title":"Kidney Int Suppl"},{"key":"10.1111\/ajt.14316_bib11","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s12020-016-0943-4","article-title":"SGLT2 inhibitors in the management of type 2 diabetes","volume":"53","author":"Monica Reddy","year":"2016","journal-title":"Endocrine"},{"key":"10.1111\/ajt.14316_bib12","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1111\/j.1600-6143.2009.02751.x","article-title":"Influence of sirolimus on cyclosporine-induced pancreas islet dysfunction in rats","volume":"9","author":"Song","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.14316_bib13","doi-asserted-by":"crossref","first-page":"e100798","DOI":"10.1371\/journal.pone.0100798","article-title":"Dipeptidyl peptidase IV inhibitor MK-0626 attenuates pancreatic islet injury in tacrolimus-induced diabetic rats","volume":"9","author":"Jin","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1111\/ajt.14316_bib14","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1124\/jpet.114.213454","article-title":"The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves beta-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat","volume":"350","author":"Hansen","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/ajt.14316_bib15","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1097\/01.TP.0000155305.49439.4C","article-title":"Combined effects of losartan and pravastatin on interstitial inflammation and fibrosis in chronic cyclosporine-induced nephropathy","volume":"79","author":"Li","year":"2005","journal-title":"Transplantation"},{"key":"10.1111\/ajt.14316_bib16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/TP.0b013e3182421604","article-title":"Drug interaction between cyclosporine and mTOR inhibitors in experimental model of chronic cyclosporine nephrotoxicity and pancreatic islet dysfunction","volume":"93","author":"Piao","year":"2012","journal-title":"Transplantation"},{"key":"10.1111\/ajt.14316_bib17","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1111\/j.1600-6143.2005.00979.x","article-title":"Rosiglitazone protects against cyclosporine-induced pancreatic and renal injury in rats","volume":"5","author":"Chung","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.14316_bib18","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3904\/kjim.2015.394","article-title":"Effects of metformin on hyperglycemia in an experimental model of tacrolimus- and sirolimus-induced diabetic rats","volume":"32","author":"Jin","year":"2017","journal-title":"Korean J Intern Med"},{"key":"10.1111\/ajt.14316_bib19","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1093\/ndt\/gfq537","article-title":"Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy","volume":"26","author":"Yoon","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1111\/ajt.14316_bib20","doi-asserted-by":"crossref","first-page":"F46","DOI":"10.1152\/ajprenal.00428.2002","article-title":"Pravastatin treatment attenuates interstitial inflammation and fibrosis in a rat model of chronic cyclosporine-induced nephropathy","volume":"286","author":"Li","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1111\/ajt.14316_bib21","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1159\/000089905","article-title":"Inhibitory effect of pravastatin on transforming growth factor beta1-inducible gene h3 expression in a rat model of chronic cyclosporine nephropathy","volume":"25","author":"Li","year":"2005","journal-title":"Am J Nephrol"},{"key":"10.1111\/ajt.14316_bib22","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/TP.0b013e31825ace5c","article-title":"Chronic cyclosporine nephropathy is characterized by excessive autophagosome formation and decreased autophagic clearance","volume":"94","author":"Lim","year":"2012","journal-title":"Transplantation"},{"key":"10.1111\/ajt.14316_bib23","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/TP.0b013e318296c9a9","article-title":"Influence of N-acetylcysteine on Klotho expression and its signaling pathway in experimental model of chronic cyclosporine nephropathy in mice","volume":"96","author":"Piao","year":"2013","journal-title":"Transplantation"},{"key":"10.1111\/ajt.14316_bib24","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/nep.12273","article-title":"Ginseng treatment attenuates autophagic cell death in chronic cyclosporine nephropathy","volume":"19","author":"Lim","year":"2014","journal-title":"Nephrology"},{"key":"10.1111\/ajt.14316_bib25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.trsl.2016.03.012","article-title":"Effects of addition of a dipeptidyl peptidase IV inhibitor to metformin on sirolimus-induced diabetes mellitus","volume":"174","author":"Jin","year":"2016","journal-title":"Transl Res"},{"key":"10.1111\/ajt.14316_bib26","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/aps.2013.2","article-title":"Characterization of a novel curcumin analog P1 as potent inhibitor of the NF-kappaB signaling pathway with distinct mechanisms","volume":"34","author":"Peng","year":"2013","journal-title":"Acta Pharmacol Sin"},{"key":"10.1111\/ajt.14316_bib27","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1517\/14740338.2016.1135900","article-title":"A safety evaluation of empagliflozin for the treatment of type 2 diabetes","volume":"15","author":"Neeland","year":"2016","journal-title":"Expert Opin Drug Saf"},{"key":"10.1111\/ajt.14316_bib28","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1358\/dot.2015.51.9.2368554","article-title":"Empagliflozin: A new treatment option for patients with type 2 diabetes mellitus","volume":"51","author":"Dailey","year":"2015","journal-title":"Drugs Today (Barc)"},{"key":"10.1111\/ajt.14316_bib29","doi-asserted-by":"crossref","first-page":"F188","DOI":"10.1152\/ajprenal.00518.2013","article-title":"Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia","volume":"306","author":"Rieg","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1111\/ajt.14316_bib30","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/ehjcvp\/pvw014","article-title":"SGLT1 does compensate for SGLT2 inhibition","volume":"2","author":"Martinez-Martin","year":"2016","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"10.1111\/ajt.14316_bib31","doi-asserted-by":"crossref","first-page":"5335","DOI":"10.1074\/jbc.M117.779520","article-title":"SGLT2 expression is increased in human diabetic nephropathy: SGLT2 inhibition decreases renal lipid accumulation, inflammation and the development of nephropathy in diabetic mice","volume":"292","author":"Wang","year":"2017","journal-title":"J Biol Chem"},{"key":"10.1111\/ajt.14316_bib32","first-page":"75","article-title":"Renin mRNA expression and renal dysfunction in tacrolimus-induced acute nephrotoxicity","volume":"11","author":"Nakatani","year":"2003","journal-title":"Int J Mol Med"},{"key":"10.1111\/ajt.14316_bib33","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/hr.2014.79","article-title":"Tacrolimus-induced hypertension and nephrotoxicity in Fawn-Hooded rats are attenuated by dual inhibition of renin-angiotensin system","volume":"37","author":"Hoskova","year":"2014","journal-title":"Hypertens Res"},{"key":"10.1111\/ajt.14316_bib34","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1172\/JCI117251","article-title":"Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells","volume":"93","author":"Kagami","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1111\/ajt.14316_bib35","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1046\/j.1523-1755.1998.00164.x","article-title":"Targeting TGF-beta overexpression in renal disease: Maximizing the antifibrotic action of angiotensin II blockade","volume":"54","author":"Peters","year":"1998","journal-title":"Kidney Int"},{"key":"10.1111\/ajt.14316_bib36","doi-asserted-by":"crossref","first-page":"e0165703","DOI":"10.1371\/journal.pone.0165703","article-title":"Effect of sodium-glucose co-transporter 2 inhibitor, dapagliflozin, on renal renin-angiotensin system in an animal model of type 2","volume":"11","author":"Shin","year":"2016","journal-title":"PLoS One"},{"key":"10.1111\/ajt.14316_bib37","first-page":"510","article-title":"The effect of tacrolimus on reactive oxygen species and total antioxidant status in pancreatic beta cell line","volume":"13","author":"Namvaran","year":"2015","journal-title":"Exp Clin Transplant"},{"key":"10.1111\/ajt.14316_bib38","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1159\/000342117","article-title":"Statin upregulates the expression of klotho, an anti-aging gene, in experimental cyclosporine nephropathy","volume":"120","author":"Yoon","year":"2012","journal-title":"Nephron Exp Nephrol"},{"key":"10.1111\/ajt.14316_bib39","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13098-015-0044-1","article-title":"Insulin stimulates SGLT2-mediated tubular glucose absorption via oxidative stress generation","volume":"7","author":"Nakamura","year":"2015","journal-title":"Diabetol Metab Syndr"},{"key":"10.1111\/ajt.14316_bib40","doi-asserted-by":"crossref","first-page":"e0158810","DOI":"10.1371\/journal.pone.0158810","article-title":"Dapagliflozin, SGLT2 inhibitor attenuates renal ischemia-reperfusion injury","volume":"11","author":"Chang","year":"2016","journal-title":"PLoS One"},{"key":"10.1111\/ajt.14316_bib41","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1056\/NEJMoa1515920","article-title":"Empagliflozin and progression of kidney disease in type 2 diabetes","volume":"375","author":"Wanner","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1111\/ajt.14316_bib42","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1111\/ajt.13322","article-title":"Safe conversion from tacrolimus to belatacept in high immunologic risk kidney transplant recipients with allograft dysfunction","volume":"15","author":"Gupta","year":"2015","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.14316_bib43","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000169066","article-title":"Comparative acute nephrotoxicity of FK-506 and ciclosporin in an isolated in situ autoperfused rat kidney model","volume":"17","author":"Bagnis","year":"1997","journal-title":"Am J Nephrol"},{"key":"10.1111\/ajt.14316_bib44","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1097\/TP.0b013e31824f3dae","article-title":"Acute effects of calcineurin inhibitors on kidney allograft microperfusion visualized by contrast-enhanced sonography","volume":"93","author":"Kihm","year":"2012","journal-title":"Transplantation"},{"issue":"Suppl 2","key":"10.1111\/ajt.14316_bib45","doi-asserted-by":"crossref","first-page":"S165","DOI":"10.2337\/dcS15-3006","article-title":"SGLT2 inhibitors and the diabetic kidney","volume":"39","author":"Fioretto","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1111\/ajt.14316_bib46","doi-asserted-by":"crossref","first-page":"S291","DOI":"10.1681\/ASN.2006080929","article-title":"New-onset diabetes after kidney transplantation: Risk factors","volume":"17","author":"Rodrigo","year":"2006","journal-title":"J Am Soc Nephrol"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.14316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.14316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajt.14316","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522251661?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522251661?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.14316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:17:19Z","timestamp":1761628639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522251661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S1600613522251661"],"URL":"https:\/\/doi.org\/10.1111\/ajt.14316","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Empagliflozin on Tacrolimus-Induced Pancreas Islet Dysfunction and Renal Injury","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.14316","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}