{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:31:10Z","timestamp":1790775070953,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"vor","delay-in-days":1814,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000885","name":"Children's Cancer Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000885","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Blood and Marrow Transplant Research Fund"},{"DOI":"10.13039\/100009378","name":"Leukemia and Lymphoma Research","doi-asserted-by":"publisher","award":["R6029-07"],"award-info":[{"award-number":["R6029-07"]}],"id":[{"id":"10.13039\/100009378","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK050456"],"award-info":[{"award-number":["P30 DK050456"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL114512-01"],"award-info":[{"award-number":["R01 HL114512-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AI056299"],"award-info":[{"award-number":["P01 AI056299"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NCI P01 CA067493"],"award-info":[{"award-number":["NCI P01 CA067493"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["8UL1TR000114"],"award-info":[{"award-number":["8UL1TR000114"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA77598"],"award-info":[{"award-number":["P30 CA77598"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HB037164"],"award-info":[{"award-number":["N01HB037164"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 CA157971"],"award-info":[{"award-number":["R01 CA157971"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["CA177119"],"award-info":[{"award-number":["CA177119"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000901","name":"Juvenile Diabetes Research Foundation International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1111\/ajt.14338","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T03:22:42Z","timestamp":1493868162000},"page":"3098-3113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines"],"prefix":"10.1016","volume":"17","author":[{"given":"K.L.","family":"Hippen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.S.","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Lemire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.A.","family":"Hanse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.C.","family":"Tennis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.C.","family":"Merkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kelekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Riley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.L.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.H.","family":"June","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.A.","family":"Turka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.S.","family":"Kean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.L.","family":"MacMillan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.S.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.E.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.H.","family":"Munn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.R.","family":"Blazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/ajt.14338_bib1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.immuni.2009.04.006","article-title":"Human T regulatory cell therapy: Take a billion or so and call me in the morning","volume":"30","author":"Riley","year":"2009","journal-title":"Immunity"},{"key":"10.1111\/ajt.14338_bib2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nri3212","article-title":"Advances in graft-versus-host disease biology and therapy","volume":"12","author":"Blazar","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1111\/ajt.14338_bib3","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s10875-008-9242-z","article-title":"T regulatory cells in autoimmune diabetes: Past challenges, future prospects","volume":"28","author":"Bluestone","year":"2008","journal-title":"J Clin Immunol"},{"key":"10.1111\/ajt.14338_bib4","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1182\/blood-2010-07-293795","article-title":"Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics","volume":"117","author":"Brunstein","year":"2011","journal-title":"Blood"},{"key":"10.1111\/ajt.14338_bib5","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1182\/blood-2015-06-653667","article-title":"Umbilical cord blood-derived T regulatory cells to prevent GVHD: Kinetics, toxicity profile, and clinical effect","volume":"127","author":"Brunstein","year":"2016","journal-title":"Blood"},{"key":"10.1111\/ajt.14338_bib6","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.smim.2011.07.008","article-title":"Clinical perspectives for regulatory T cells in transplantation tolerance","volume":"23","author":"Hippen","year":"2011","journal-title":"Semin Immunol"},{"key":"10.1111\/ajt.14338_bib7","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.immuni.2011.03.029","article-title":"A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity","volume":"35","author":"Haribhai","year":"2011","journal-title":"Immunity"},{"key":"10.1111\/ajt.14338_bib8","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1111\/j.1600-6143.2011.03558.x","article-title":"Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease","volume":"11","author":"Hippen","year":"2011","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.14338_bib9","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.immuni.2015.02.004","article-title":"Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy","volume":"42","author":"Noval Rivas","year":"2015","journal-title":"Immunity"},{"key":"10.1111\/ajt.14338_bib10","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.4049\/jimmunol.181.8.5396","article-title":"The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation","volume":"181","author":"Chen","year":"2008","journal-title":"J Immunol"},{"key":"10.1111\/ajt.14338_bib11","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.4049\/jimmunol.173.7.4433","article-title":"Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells","volume":"173","author":"Moseman","year":"2004","journal-title":"J Immunol"},{"key":"10.1111\/ajt.14338_bib12","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1126\/science.281.5380.1191","article-title":"Prevention of allogeneic fetal rejection by tryptophan catabolism","volume":"281","author":"Munn","year":"1998","journal-title":"Science"},{"key":"10.1111\/ajt.14338_bib13","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nm1196","article-title":"Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy","volume":"11","author":"Muller","year":"2005","journal-title":"Nat Med"},{"key":"10.1111\/ajt.14338_bib14","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1053\/j.gastro.2003.08.031","article-title":"Inhibition of indoleamine 2,3-dioxygenase augments trinitrobenzene sulfonic acid colitis in mice","volume":"125","author":"Gurtner","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1111\/ajt.14338_bib15","doi-asserted-by":"crossref","first-page":"R50","DOI":"10.1186\/ar2205","article-title":"Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in mice","volume":"9","author":"Szanto","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"10.1111\/ajt.14338_bib16","doi-asserted-by":"crossref","first-page":"5062","DOI":"10.1182\/blood-2009-06-227587","article-title":"Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality","volume":"114","author":"Jasperson","year":"2009","journal-title":"Blood"},{"key":"10.1111\/ajt.14338_bib17","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1182\/blood-2007-06-096081","article-title":"Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality","volume":"111","author":"Jasperson","year":"2008","journal-title":"Blood"},{"key":"10.1111\/ajt.14338_bib18","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1172\/JCI31911","article-title":"Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase","volume":"117","author":"Sharma","year":"2007","journal-title":"J Clin Investig"},{"key":"10.1111\/ajt.14338_bib19","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.immuni.2010.11.022","article-title":"Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice","volume":"33","author":"Sharma","year":"2010","journal-title":"Immunity"},{"key":"10.1111\/ajt.14338_bib20","doi-asserted-by":"crossref","first-page":"6102","DOI":"10.1182\/blood-2008-12-195354","article-title":"Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes","volume":"113","author":"Sharma","year":"2009","journal-title":"Blood"},{"key":"10.1111\/ajt.14338_bib21","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.immuni.2013.01.013","article-title":"An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos","volume":"38","author":"Sharma","year":"2013","journal-title":"Immunity"},{"key":"10.1111\/ajt.14338_bib22","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev-immunol-032712-095956","article-title":"Metabolic regulation of T lymphocytes","volume":"31","author":"MacIver","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"10.1111\/ajt.14338_bib23","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/mt.sj.6300134","article-title":"Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules","volume":"15","author":"Suhoski","year":"2007","journal-title":"Mol Ther"},{"key":"10.1111\/ajt.14338_bib24","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1182\/blood-2008-01-132951","article-title":"Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells","volume":"112","author":"Hippen","year":"2008","journal-title":"Blood"},{"key":"10.1111\/ajt.14338_bib25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nri2474","article-title":"Epigenetic control of FOXP3 expression: The key to a stable regulatory T-cell lineage?","volume":"9","author":"Huehn","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1111\/ajt.14338_bib26","doi-asserted-by":"crossref","first-page":"976","DOI":"10.4049\/jimmunol.1102964","article-title":"Expression of Helios in peripherally induced Foxp3+ regulatory T cells","volume":"188","author":"Gottschalk","year":"2012","journal-title":"J Immunol"},{"key":"10.1111\/ajt.14338_bib27","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1084\/jem.20062512","article-title":"Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression","volume":"204","author":"Deaglio","year":"2007","journal-title":"J Exp Med"},{"key":"10.1111\/ajt.14338_bib28","first-page":"1","article-title":"Human CD39hi regulatory T cells present stronger stability and function under inflammatory conditions","volume":"13","author":"Gu","year":"2016","journal-title":"Cell Mol Immunol"},{"key":"10.1111\/ajt.14338_bib29","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.4049\/jimmunol.1203547","article-title":"IL-7 modulates in vitro and in vivo human memory T regulatory cell functions through the CD39\/ATP axis","volume":"191","author":"Younas","year":"2013","journal-title":"J Immunol"},{"key":"10.1111\/ajt.14338_bib30","doi-asserted-by":"crossref","first-page":"67ra68","DOI":"10.1126\/scitranslmed.3001975","article-title":"Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease","volume":"3","author":"Gatza","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.1111\/ajt.14338_bib31","doi-asserted-by":"crossref","first-page":"18782","DOI":"10.1073\/pnas.0810199105","article-title":"Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction","volume":"105","author":"Wise","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/ajt.14338_bib32","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nrc.2016.71","article-title":"From Krebs to clinic: Glutamine metabolism to cancer therapy","volume":"16","author":"Altman","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"10.1111\/ajt.14338_bib33","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/ni.3504","article-title":"CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis","volume":"17","author":"Cibrian","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1111\/ajt.14338_bib34","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O\u2019Neill","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"10.1111\/ajt.14338_bib35","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/nri3874","article-title":"Synchronizing transcriptional control of T cell metabolism and function","volume":"15","author":"Man","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"10.1111\/ajt.14338_bib36","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.it.2014.12.005","article-title":"Fatty acid metabolism in the regulation of T cell function","volume":"36","author":"Lochner","year":"2015","journal-title":"Trends Immunol"},{"key":"10.1111\/ajt.14338_bib37","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.immuni.2014.06.005","article-title":"Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development","volume":"41","author":"O\u2019Sullivan","year":"2014","journal-title":"Immunity"},{"key":"10.1111\/ajt.14338_bib38","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.cell.2015.03.021","article-title":"IL-7-induced glycerol transport and TAG synthesis promotes memory CD8+ T cell longevity","volume":"161","author":"Cui","year":"2015","journal-title":"Cell"},{"key":"10.1111\/ajt.14338_bib39","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev.immunol.17.1.221","article-title":"Mature T lymphocyte apoptosis\u2013immune regulation in a dynamic and unpredictable antigenic environment","volume":"17","author":"Lenardo","year":"1999","journal-title":"Annu Rev Immunol"},{"key":"10.1111\/ajt.14338_bib40","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jaut.2014.10.002","article-title":"Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells","volume":"56","author":"Bell","year":"2015","journal-title":"J Autoimmun"},{"key":"10.1111\/ajt.14338_bib41","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1056\/NEJMoa1108188","article-title":"Interleukin-2 and regulatory T cells in graft-versus-host disease","volume":"365","author":"Koreth","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1111\/ajt.14338_bib42","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1056\/NEJMoa1105143","article-title":"Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis","volume":"365","author":"Saadoun","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1111\/ajt.14338_bib43","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1158\/1078-0432.CCR-13-3205","article-title":"Ultra low-dose IL-2 for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation mediates expansion of regulatory T cells without diminishing antiviral and antileukemic activity","volume":"20","author":"Kennedy-Nasser","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1111\/ajt.14338_bib44","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.4161\/onci.21716","article-title":"IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan","volume":"1","author":"Metz","year":"2012","journal-title":"Oncoimmunology"},{"key":"10.1111\/ajt.14338_bib45","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0891-5849(98)00163-4","article-title":"Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical","volume":"25","author":"Benov","year":"1998","journal-title":"Free Radic Biol Med"},{"key":"10.1111\/ajt.14338_bib46","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1038\/emboj.2011.307","article-title":"Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases","volume":"30","author":"Strasser","year":"2011","journal-title":"EMBO J"},{"key":"10.1111\/ajt.14338_bib47","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1182\/blood-2010-10-311894","article-title":"Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation","volume":"117","author":"Di Ianni","year":"2011","journal-title":"Blood"},{"key":"10.1111\/ajt.14338_bib48","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1182\/blood-2014-03-564401","article-title":"HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse","volume":"124","author":"Martelli","year":"2014","journal-title":"Blood"},{"key":"10.1111\/ajt.14338_bib49","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bcp.2016.02.020","article-title":"Aryl hydrocarbon receptor (AHR) regulation of L-Type Amino Acid Transporter 1 (LAT-1) expression in MCF-7 and MDA-MB-231 breast cancer cells","volume":"106","author":"Tomblin","year":"2016","journal-title":"Biochem Pharmacol"},{"key":"10.1111\/ajt.14338_bib50","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/ni.2556","article-title":"Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation","volume":"14","author":"Sinclair","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1111\/ajt.14338_bib51","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.immuni.2011.10.003","article-title":"The end and after: How dying cells impact the living organism","volume":"35","author":"Green","year":"2011","journal-title":"Immunity"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.14338","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522252393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522252393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/ajt.14338\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:17:58Z","timestamp":1761628678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522252393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S1600613522252393"],"URL":"https:\/\/doi.org\/10.1111\/ajt.14338","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.14338","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}