{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:23:45Z","timestamp":1790493825174,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"vor","delay-in-days":1905,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32AI125222"],"award-info":[{"award-number":["T32AI125222"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008069","name":"University of California, San Francisco","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008069","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1111\/ajt.14344","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T09:26:48Z","timestamp":1494408408000},"page":"2444-2450","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pancreas-After-Islet Transplantation in Nonuremic Type 1 Diabetes: A Strategy for Restoring Durable Insulin Independence"],"prefix":"10.1016","volume":"17","author":[{"given":"S.A.","family":"Wisel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.R.","family":"Roll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Harbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.E.","family":"Freise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.B.","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Posselt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.G.","family":"Stock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/ajt.14344_bib1","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1097\/TP.0000000000000217","article-title":"Single-donor islet transplantation and long-term insulin independence in select patients with type 1 diabetes mellitus","volume":"98","author":"Al-Adra","year":"2014","journal-title":"Transplantation"},{"key":"10.1111\/ajt.14344_bib2","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1111\/j.1600-6143.2011.03977.x","article-title":"Potent induction immunotherapy promotes long-term insulin independence after islet transplantation in type 1 diabetes","volume":"12","author":"Bellin","year":"2012","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.14344_bib3","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.2337\/dc15-0094","article-title":"Five-year metabolic, functional, and safety results of patients with type 1 diabetes transplanted with allogenic islets within the Swiss-French GRAGIL network","volume":"38","author":"Lablanche","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1111\/ajt.14344_bib4","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.diabet.2013.10.003","article-title":"Treating diabetes with islet transplantation: Lessons from the past decade in Lille","volume":"40","author":"Vantyghem","year":"2014","journal-title":"Diabetes Metab"},{"key":"10.1111\/ajt.14344_bib5","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s00592-014-0627-6","article-title":"Five-year follow-up of patients with type 1 diabetes transplanted with allogeneic islets: The UIC experience","volume":"51","author":"Qi","year":"2014","journal-title":"Acta Diabetol"},{"key":"10.1111\/ajt.14344_bib6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.5500\/wjt.v3.i4.48","article-title":"Current status of clinical islet transplantation","volume":"3","author":"Pepper","year":"2013","journal-title":"World J Transplant"},{"key":"10.1111\/ajt.14344_bib7","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/ajt.13536","article-title":"A comparative analysis of the safety, efficacy, and cost of islet versus pancreas transplantation in nonuremic patients with type 1 diabetes","volume":"16","author":"Moassesfar","year":"2016","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.14344_bib8","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1111\/j.1600-6143.2011.03729.x","article-title":"Posttransplant donor-specific anti-HLA antibodies negatively impact pancreas transplantation outcome","volume":"11","author":"Cantarovich","year":"2011","journal-title":"Am J Transplant"},{"issue":"Suppl 2","key":"10.1111\/ajt.14344_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/ajt.13196","article-title":"OPTN\/SRTR 2013 annual data report: Pancreas","volume":"15","author":"Kandaswamy","year":"2015","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.14344_bib10","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1111\/ajt.13468","article-title":"Pancreas after islet transplantation: A first report of the international pancreas transplant registry","volume":"16","author":"Gruessner","year":"2016","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.14344_bib11","doi-asserted-by":"crossref","first-page":"e1126036","DOI":"10.1080\/19382014.2015.1126036","article-title":"Islet-after-failed-pancreas and pancreas-after-failed islet transplantation: Two complementary rescue strategies to control diabetes","volume":"7","author":"Andres","year":"2016","journal-title":"Islets"},{"key":"10.1111\/ajt.14344_bib12","first-page":"235","article-title":"Clinical islet transplantation at the University of California San Francisco","volume":"24","author":"Posselt","year":"2010","journal-title":"Clin Transpl"},{"key":"10.1111\/ajt.14344_bib13","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2337\/diab.37.4.413","article-title":"Automated method for isolation of human pancreatic islets","volume":"37","author":"Ricordi","year":"1988","journal-title":"Diabetes"},{"key":"10.1111\/ajt.14344_bib14","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/TP.0b013e3181b443ae","article-title":"Successful clinical islet isolation using a GMP-manufactured collagenase and neutral protease","volume":"88","author":"Szot","year":"2009","journal-title":"Transplantation"},{"key":"10.1111\/ajt.14344_bib15","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1148\/radiol.2291021632","article-title":"Percutaneous transhepatic pancreatic islet cell transplantation in type 1 diabetes mellitus: Radiologic aspects","volume":"229","author":"Owen","year":"2003","journal-title":"Radiology"},{"key":"10.1111\/ajt.14344_bib16","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","article-title":"Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen","volume":"343","author":"Shapiro","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1111\/ajt.14344_bib17","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1097\/TP.0b013e3181fe1377","article-title":"Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade","volume":"90","author":"Posselt","year":"2010","journal-title":"Transplantation"},{"key":"10.1111\/ajt.14344_bib18","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1111\/j.1600-6143.2010.03073.x","article-title":"Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab","volume":"10","author":"Posselt","year":"2010","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.14344_bib19","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.ecl.2007.07.010","article-title":"Pancreas-kidney and pancreas transplantation for the treatment of diabetes mellitus","volume":"36","author":"Lipshutz","year":"2007","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1111\/ajt.14344_bib20","doi-asserted-by":"crossref","first-page":"901","DOI":"10.3727\/096368911X612468","article-title":"HLA class I sensitization in islet transplant recipients: Report from the collaborative islet transplant registry","volume":"21","author":"Naziruddin","year":"2012","journal-title":"Cell Transplant"},{"key":"10.1111\/ajt.14344_bib21","doi-asserted-by":"crossref","first-page":"951","DOI":"10.4239\/wjd.v5.i6.951","article-title":"Pancreas transplantation: The wake forest experience in the new millennium","volume":"5","author":"Rogers","year":"2014","journal-title":"World J Diabetes"},{"key":"10.1111\/ajt.14344_bib22","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1111\/ajt.12443","article-title":"Acute cellular and antibody-mediated rejection of the pancreas allograft: Incidence, risk factors and outcomes","volume":"13","author":"Niederhaus","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1111\/ajt.14344_bib23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/MOT.0b013e32835c51b5","article-title":"Immunological monitoring after pancreas transplantation","volume":"18","author":"Margreiter","year":"2013","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1111\/ajt.14344_bib24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1056\/NEJM199807093390202","article-title":"Reversal of lesions of diabetic nephropathy after pancreas transplantation","volume":"339","author":"Fioretto","year":"1998","journal-title":"N Engl J Med"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.14344","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522251387?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522251387?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/ajt.14344\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:17:24Z","timestamp":1761628644000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522251387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S1600613522251387"],"URL":"https:\/\/doi.org\/10.1111\/ajt.14344","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pancreas-After-Islet Transplantation in Nonuremic Type 1 Diabetes: A Strategy for Restoring Durable Insulin Independence","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.14344","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}