{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:53:39Z","timestamp":1790052819631,"version":"4.0.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":1356,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["J3414"],"award-info":[{"award-number":["J3414"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19AI051731"],"award-info":[{"award-number":["U19AI051731"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1111\/ajt.15067","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T12:03:26Z","timestamp":1534161806000},"page":"724-736","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients"],"prefix":"10.1016","volume":"19","author":[{"given":"Christopher K.","family":"Burghuber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6474-6122","authenticated-orcid":false,"given":"Miriam","family":"Manook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Ezekian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana C.","family":"Gibby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank V.","family":"Leopardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minqing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Jenks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Saccoccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sallie","family":"Permar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alton B.","family":"Farris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal N.","family":"Iwakoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8563-5472","authenticated-orcid":false,"given":"Jean","family":"Kwun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart J.","family":"Knechtle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl 1","key":"10.1111\/ajt.15067_bib1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/ajt.14124","article-title":"OPTN\/SRTR 2015 annual data report: kidney","volume":"17","author":"Hart","year":"2017","journal-title":"Am J Transplant."},{"issue":"8","key":"10.1111\/ajt.15067_bib2","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1034\/j.1600-6143.2003.00180.x","article-title":"Overcoming a positive crossmatch in living-donor kidney transplantation","volume":"3","author":"Gloor","year":"2003","journal-title":"Am J Transplant."},{"issue":"12","key":"10.1111\/ajt.15067_bib3","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1097\/01.TP.0000442782.98131.7c","article-title":"Long-term outcomes of kidney transplantation across a positive complement-dependent cytotoxicity crossmatch","volume":"97","author":"Riella","year":"2014","journal-title":"Transplantation."},{"issue":"9","key":"10.1111\/ajt.15067_bib4","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1111\/j.1600-6143.2010.03226.x","article-title":"Peritransplant immunoadsorption for positive crossmatch deceased donor kidney transplantation","volume":"10","author":"Bartel","year":"2010","journal-title":"Am J Transplant."},{"issue":"3","key":"10.1111\/ajt.15067_bib5","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.1600-6143.2009.02985.x","article-title":"Baseline donor-specific antibody levels and outcomes in positive crossmatch kidney transplantation","volume":"10","author":"Gloor","year":"2010","journal-title":"Am J Transplant."},{"issue":"3","key":"10.1111\/ajt.15067_bib6","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1600-6143.2008.02524.x","article-title":"Positive cross-match living donor kidney transplantation: longer-term outcomes","volume":"9","author":"Haririan","year":"2009","journal-title":"Am J Transplant."},{"issue":"12","key":"10.1111\/ajt.15067_bib7","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1097\/01.ASN.0000145878.92906.9F","article-title":"Evaluation of intravenous immunoglobulin as an agent to lower allosensitization and improve transplantation in highly sensitized adult patients with end-stage renal disease: report of the NIH IG02 trial","volume":"15","author":"Jordan","year":"2004","journal-title":"J Am Soc Nephrol."},{"issue":"4","key":"10.1111\/ajt.15067_bib8","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1056\/NEJMoa1012376","article-title":"Desensitization in HLA-incompatible kidney recipients and survival","volume":"365","author":"Montgomery","year":"2011","journal-title":"N Engl J Med."},{"issue":"1","key":"10.1111\/ajt.15067_bib9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1600-6143.2012.04291.x","article-title":"Five-year outcomes in living donor kidney transplants with a positive crossmatch","volume":"13","author":"Bentall","year":"2013","journal-title":"Am J Transplant."},{"issue":"4","key":"10.1111\/ajt.15067_bib10","doi-asserted-by":"crossref","first-page":"922","DOI":"10.2215\/CJN.08140910","article-title":"Desensitization protocols and their outcome","volume":"6","author":"Marfo","year":"2011","journal-title":"Clin J Am Soc Nephrol."},{"issue":"1","key":"10.1111\/ajt.15067_bib11","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1365-2567.2006.02487.x","article-title":"Proteasomal chymotrypsin-like peptidase activity is required for essential functions of human monocyte-derived dendritic cells","volume":"120","author":"Naujokat","year":"2007","journal-title":"Immunology."},{"issue":"1","key":"10.1111\/ajt.15067_bib12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1600-6143.2008.02461.x","article-title":"Proteasome inhibition causes apoptosis of normal human plasma cells preventing alloantibody production","volume":"9","author":"Perry","year":"2009","journal-title":"Am J Transplant."},{"issue":"5","key":"10.1111\/ajt.15067_bib13","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/TP.0b013e3182081333","article-title":"The impact of proteasome inhibition on alloantibody-producing plasma cells in vivo","volume":"91","author":"Diwan","year":"2011","journal-title":"Transplantation."},{"issue":"12","key":"10.1111\/ajt.15067_bib14","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1097\/TP.0b013e318190af83","article-title":"Bortezomib provides effective therapy for antibody- and cell-mediated acute rejection","volume":"86","author":"Everly","year":"2008","journal-title":"Transplantation."},{"issue":"3","key":"10.1111\/ajt.15067_bib15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/TP.0b013e3181c6ff8d","article-title":"Proteasome inhibitor-based primary therapy for antibody-mediated renal allograft rejection","volume":"89","author":"Walsh","year":"2010","journal-title":"Transplantation."},{"issue":"1","key":"10.1111\/ajt.15067_bib16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/ajt.13050","article-title":"Prospective iterative trial of proteasome inhibitor-based desensitization","volume":"15","author":"Woodle","year":"2015","journal-title":"Am J Transplant."},{"issue":"8","key":"10.1111\/ajt.15067_bib17","doi-asserted-by":"crossref","first-page":"E280","DOI":"10.1111\/petr.12347","article-title":"HLA desensitization with bortezomib in a highly sensitized pediatric patient","volume":"18","author":"May","year":"2014","journal-title":"Pediatr Transplant."},{"issue":"5","key":"10.1111\/ajt.15067_bib18","doi-asserted-by":"crossref","first-page":"e2635","DOI":"10.1097\/MD.0000000000002635","article-title":"Desensitization using bortezomib and high-dose immunoglobulin increases rate of deceased donor kidney transplantation","volume":"95","author":"Jeong","year":"2016","journal-title":"Medicine (Baltimore)."},{"issue":"2","key":"10.1111\/ajt.15067_bib19","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1681\/ASN.2017070818","article-title":"A randomized trial of bortezomib in late antibody-mediated kidney transplant rejection","volume":"29","author":"Eskandary","year":"2018","journal-title":"J Am Soc Nephrol."},{"issue":"4","key":"10.1111\/ajt.15067_bib20","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/ajt.12636","article-title":"Antibody desensitization therapy in highly sensitized lung transplant candidates","volume":"14","author":"Snyder","year":"2014","journal-title":"Am J Transplant."},{"issue":"6","key":"10.1111\/ajt.15067_bib21","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1111\/ajt.13688","article-title":"Antibody-mediated rejection in sensitized nonhuman primates: modeling human biology","volume":"16","author":"Burghuber","year":"2016","journal-title":"Am J Transplant."},{"issue":"7","key":"10.1111\/ajt.15067_bib22","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1681\/ASN.2016070727","article-title":"Humoral compensation after bortezomib treatment of allosensitized recipients","volume":"28","author":"Kwun","year":"2017","journal-title":"J Am Soc Nephrol."},{"issue":"2","key":"10.1111\/ajt.15067_bib23","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/ajt.12590","article-title":"Banff 2013 meeting report: inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions","volume":"14","author":"Haas","year":"2014","journal-title":"Am J Transplant."},{"issue":"1","key":"10.1111\/ajt.15067_bib24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/ajt.14107","article-title":"The Banff 2015 kidney meeting report: current challenges in rejection classification and prospects for adopting molecular pathology","volume":"17","author":"Loupy","year":"2017","journal-title":"Am J Transplant."},{"issue":"6","key":"10.1111\/ajt.15067_bib25","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/TP.0000000000000132","article-title":"Differential effect of bortezomib on HLA class I and class II antibody","volume":"98","author":"Philogene","year":"2014","journal-title":"Transplantation."},{"issue":"12","key":"10.1111\/ajt.15067_bib26","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1681\/ASN.V12122807","article-title":"Flow cytometric crossmatching in primary renal transplant recipients with a negative anti-human globulin enhanced cytotoxicity crossmatch","volume":"12","author":"Karpinski","year":"2001","journal-title":"J Am Soc Nephrol."},{"issue":"4","key":"10.1111\/ajt.15067_bib27","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/01.TP.0000047311.77702.59","article-title":"Identification of the antibodies involved in B-cell crossmatch positivity in renal transplantation","volume":"75","author":"Le Bas-Bernardet","year":"2003","journal-title":"Transplantation."},{"key":"10.1111\/ajt.15067_bib28","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1182\/bloodadvances.2017010991","article-title":"Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates","volume":"1","author":"Kwun","year":"2017","journal-title":"Blood Adv."},{"key":"10.1111\/ajt.15067_bib29","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.trim.2016.08.001","article-title":"Immunological characterization of de novo and recall alloantibody suppression by CTLA4Ig in a mouse model of allosensitization","volume":"38","author":"Kim","year":"2016","journal-title":"Transplant Immunol."},{"key":"10.1111\/ajt.15067_bib30","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/jcp.24572","article-title":"CD40 signaling drives B lymphocytes into an intermediate memory-like state, poised between na\u00efve and plasma cells","volume":"229","author":"Upadhyay","year":"2014","journal-title":"J Cell Physiol."},{"issue":"4","key":"10.1111\/ajt.15067_bib31","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1056\/NEJMoa1506027","article-title":"Belatacept and long-term outcomes in kidney transplantation","volume":"374","author":"Vincenti","year":"2016","journal-title":"N Engl J Med."},{"issue":"1","key":"10.1111\/ajt.15067_bib32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ajt.12526","article-title":"Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection","volume":"14","author":"Kim","year":"2014","journal-title":"Am J Transplant."},{"issue":"3","key":"10.1111\/ajt.15067_bib33","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1681\/ASN.2017060679","article-title":"Control of humoral response in renal transplantation by belatacept depends on a direct effect on B cells and impaired T follicular helper-B cell crosstalk","volume":"29","author":"Leibler","year":"2018","journal-title":"J Am Soc Nephrol."},{"issue":"12","key":"10.1111\/ajt.15067_bib34","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/ni.1954","article-title":"Plasma cells negatively regulate the follicular helper T cell program","volume":"11","author":"Pelletier","year":"2010","journal-title":"Nat Immunol."},{"issue":"9","key":"10.1111\/ajt.15067_bib35","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.4049\/jimmunol.1500940","article-title":"Cutting edge: CTLA-4Ig inhibits memory B cell responses and promotes allograft survival in sensitized recipients","volume":"195","author":"Chen","year":"2015","journal-title":"J Immunol."},{"issue":"3","key":"10.1111\/ajt.15067_bib36","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.4049\/jimmunol.1100016","article-title":"CD28 expressed on malignant plasma cells induces a prosurvival and immunosuppressive microenvironment","volume":"187","author":"Nair","year":"2011","journal-title":"J Immunol."},{"issue":"10","key":"10.1111\/ajt.15067_bib37","doi-asserted-by":"crossref","first-page":"4717","DOI":"10.4049\/jimmunol.1402260","article-title":"CD28 promotes plasma cell survival, sustained antibody responses, and BLIMP-1 upregulation through its distal PYAP proline motif","volume":"194","author":"Rozanski","year":"2015","journal-title":"J Immunol."},{"issue":"1","key":"10.1111\/ajt.15067_bib38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1189\/jlb.1HI0514-243R","article-title":"Characterization of B and plasma cells in blood, bone marrow, and secondary lymphoid organs of rhesus macaques by multicolor flow cytometry","volume":"97","author":"Neumann","year":"2015","journal-title":"J Leukoc Biol."},{"issue":"5","key":"10.1111\/ajt.15067_bib39","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1056\/NEJMoa1612567","article-title":"IgG endopeptidase in highly sensitized patients undergoing transplantation","volume":"377","author":"Jordan","year":"2017","journal-title":"N Engl J Med."},{"issue":"8","key":"10.1111\/ajt.15067_bib40","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1681\/ASN.2014030249","article-title":"Cytomegalovirus and anemia: not just for transplant anymore","volume":"25","author":"Seifert","year":"2014","journal-title":"J Am Soc Nephrol."},{"key":"10.1111\/ajt.15067_bib41","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1182\/asheducation-2010.1.281","article-title":"Hematologic disorders after solid organ transplantation","volume":"2010","author":"Smith","year":"2010","journal-title":"Hematology Am Soc Hematol Educ Program."},{"issue":"3","key":"10.1111\/ajt.15067_bib42","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.transproceed.2011.11.052","article-title":"Spectrum of cytomegalovirus-induced renal pathology in renal allograft recipients","volume":"44","author":"Rane","year":"2012","journal-title":"Transplant Proc."},{"issue":"10","key":"10.1111\/ajt.15067_bib43","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1097\/00007890-199505270-00011","article-title":"Endocapillary glomerulitis in the renal allograft","volume":"59","author":"Olsen","year":"1995","journal-title":"Transplantation."},{"issue":"1","key":"10.1111\/ajt.15067_bib44","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1053\/j.ajkd.2008.02.362","article-title":"Cytomegalovirus glomerulitis in a renal allograft","volume":"52","author":"Cathro","year":"2008","journal-title":"Am J Kidney Dis."},{"issue":"7","key":"10.1111\/ajt.15067_bib45","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1034\/j.1600-6143.2002.20717.x","article-title":"Cytomegalovirus-induced glomerular vasculopathy in renal allografts: a report of two cases","volume":"2","author":"Onuigbo","year":"2002","journal-title":"Am J Transplant."},{"issue":"4","key":"10.1111\/ajt.15067_bib46","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/ndt\/16.4.861","article-title":"Acute allograft glomerulopathy associated with CMV viraemia","volume":"16","author":"Browne","year":"2001","journal-title":"Nephrol Dial Transplant."},{"issue":"11","key":"10.1111\/ajt.15067_bib47","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1681\/ASN.V8111801","article-title":"Does cytomegalovirus cause glomerular injury in renal allograft recipients?","volume":"8","author":"Birk","year":"1997","journal-title":"J Am Soc Nephrol."},{"issue":"8","key":"10.1111\/ajt.15067_bib48","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1097\/TP.0b013e31824836ae","article-title":"ABO-incompatible kidney transplantation enabled by non-antigen-specific immunoadsorption","volume":"93","author":"Morath","year":"2012","journal-title":"Transplantation."}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.15067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.15067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajt.15067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522089869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522089869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.15067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:22:19Z","timestamp":1761628939000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522089869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S1600613522089869"],"URL":"https:\/\/doi.org\/10.1111\/ajt.15067","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.15067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}