{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:09:44Z","timestamp":1790424584038,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":1173,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1111\/ajt.15340","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T23:42:30Z","timestamp":1551829350000},"page":"2434-2445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Markers of graft microvascular endothelial injury may identify harmful donor-specific anti-HLA antibodies and predict kidney allograft loss"],"prefix":"10.1016","volume":"19","author":[{"given":"Kevin","family":"Louis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Hertig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Taupin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Buob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Jamme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Brocheriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosu","family":"Luque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Jouanneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nacera","family":"Ouali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Audouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rondeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chun","family":"Xu-Dubois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/ajt.15340_bib1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3389\/fimmu.2014.00505","article-title":"Vascular endothelium as a target of immune response in renal transplant rejection","volume":"5","author":"Piotti","year":"2014","journal-title":"Front Immunol."},{"key":"10.1111\/ajt.15340_bib2","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1046\/j.1523-1755.2001.059002488.x","article-title":"Unusual expression of human lymphocyte antigen class II in normal renal microvascular endothelium","volume":"59","author":"Muczynski","year":"2001","journal-title":"Kidney Int."},{"key":"10.1111\/ajt.15340_bib3","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1073\/pnas.1011811108","article-title":"Human endothelial cells generate Th17 and regulatory T cells under inflammatory conditions","volume":"108","author":"Taflin","year":"2011","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1111\/ajt.15340_bib4","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1600-6143.2012.04325.x","article-title":"Microcirculation inflammation associates with outcome in renal transplant patients with de novo donor-specific antibodies","volume":"13","author":"de Kort","year":"2013","journal-title":"Am J Transplant."},{"key":"10.1111\/ajt.15340_bib5","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/ki.2015.64","article-title":"The diffuse extent of peritubular capillaritis in renal allograft rejection is an independent risk factor for graft loss","volume":"88","author":"Kozakowski","year":"2015","journal-title":"Kidney Int."},{"key":"10.1111\/ajt.15340_bib6","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/ctr.12258","article-title":"The specificity of acute and chronic microvascular alterations in renal allografts","volume":"27","author":"Filippone","year":"2013","journal-title":"Clin Transplant."},{"key":"10.1111\/ajt.15340_bib7","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/ajt.14625","article-title":"The Banff 2017 Kidney Meeting Report: revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials","volume":"18","author":"Haas","year":"2018","journal-title":"Am J Transplant."},{"key":"10.1111\/ajt.15340_bib8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/MNH.0000000000000398","article-title":"Evolving criteria for the diagnosis of antibody-mediated rejection in renal allografts","volume":"27","author":"Haas","year":"2018","journal-title":"Curr Opin Nephrol Hypertens."},{"key":"10.1111\/ajt.15340_bib9","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/ki.2015.103","article-title":"Interactions of DPP-4 and integrin beta1 influences endothelial-to-mesenchymal transition","volume":"88","author":"Shi","year":"2015","journal-title":"Kidney Int."},{"key":"10.1111\/ajt.15340_bib10","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1172\/JCI82719","article-title":"Endothelial-to-mesenchymal transition drives atherosclerosis progression","volume":"125","author":"Chen","year":"2015","journal-title":"J Clin Invest."},{"key":"10.1111\/ajt.15340_bib11","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/ndt\/gft516","article-title":"Endothelial-to-mesenchymal transition and renal fibrosis in ischaemia\/reperfusion injury are mediated by complement anaphylatoxins and Akt pathway","volume":"29","author":"Curci","year":"2014","journal-title":"Nephrol Dial Transplant."},{"key":"10.1111\/ajt.15340_bib12","doi-asserted-by":"crossref","first-page":"ra85","DOI":"10.1126\/scisignal.2001158","article-title":"HLA class I molecules partner with integrin beta4 to stimulate endothelial cell proliferation and migration","volume":"3","author":"Zhang","year":"2010","journal-title":"Sci Signal."},{"key":"10.1111\/ajt.15340_bib13","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1111\/j.1600-6143.2009.02761.x","article-title":"Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining","volume":"9","author":"Sis","year":"2009","journal-title":"Am J Transplant."},{"key":"10.1111\/ajt.15340_bib14","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1097\/01.tp.0000231447.34240.3c","article-title":"Anti-HLA antibodies can induce endothelial cell survival or proliferation depending on their concentration","volume":"82","author":"Jindra","year":"2006","journal-title":"Transplantation."},{"key":"10.1111\/ajt.15340_bib15","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1111\/ajt.13644","article-title":"HLA class II antibody activation of endothelial cells promotes Th17 and disrupts regulatory T lymphocyte expansion","volume":"16","author":"Lion","year":"2016","journal-title":"Am J Transplant."},{"key":"10.1111\/ajt.15340_bib16","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1681\/ASN.2014070679","article-title":"Markers of endothelial-to-mesenchymal transition: evidence for antibody-endothelium interaction during antibody-mediated rejection in kidney recipients","volume":"27","author":"Xu-Dubois","year":"2015","journal-title":"J Am Soc Nephrol."},{"key":"10.1111\/ajt.15340_bib17","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.tem.2016.06.004","article-title":"Partial epithelial-to-mesenchymal transition and other new mechanisms of kidney fibrosis","volume":"27","author":"Lovisa","year":"2016","journal-title":"Trends Endocrinol Metab."},{"key":"10.1111\/ajt.15340_bib18","doi-asserted-by":"crossref","first-page":"8746303","DOI":"10.1155\/2017\/8746303","article-title":"Endothelial cells in antibody-mediated rejection of kidney transplantation: pathogenesis mechanisms and therapeutic implications","volume":"2017","author":"Wang","year":"2017","journal-title":"J Immunol Res."},{"key":"10.1111\/ajt.15340_bib19","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1111\/j.1600-6143.2010.03201.x","article-title":"NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: evidence for NK cell involvement in antibody-mediated rejection","volume":"10","author":"Hidalgo","year":"2010","journal-title":"Am J Transplant."},{"key":"10.1111\/ajt.15340_bib20","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1681\/ASN.2013111149","article-title":"Molecular microscope strategy to improve risk stratification in early antibody-mediated kidney allograft rejection","volume":"25","author":"Loupy","year":"2014","journal-title":"J Am Soc Nephrol."},{"key":"10.1111\/ajt.15340_bib21","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nrneph.2016.85","article-title":"Molecular assessment of disease states in kidney transplant biopsy samples","volume":"12","author":"Halloran","year":"2016","journal-title":"Nat Rev Nephrol."},{"key":"10.1111\/ajt.15340_bib22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/TP.0b013e3181e065de","article-title":"Evidence for antibody-mediated injury as a major determinant of late kidney allograft failure","volume":"90","author":"Gaston","year":"2010","journal-title":"Transplantation."},{"key":"10.1111\/ajt.15340_bib23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1600-6143.2010.03364.x","article-title":"Significance of C4d Banff scores in early protocol biopsies of kidney transplant recipients with preformed donor-specific antibodies (DSA)","volume":"11","author":"Loupy","year":"2011","journal-title":"Am J Transplant."},{"key":"10.1111\/ajt.15340_bib24","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1681\/ASN.2014040399","article-title":"Subclinical rejection phenotypes at 1 year post-transplant and outcome of kidney allografts","volume":"26","author":"Loupy","year":"2015","journal-title":"J Am Soc Nephrol."},{"key":"10.1111\/ajt.15340_bib25","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1681\/ASN.2014111120","article-title":"IgG donor-specific anti-human HLA antibody subclasses and kidney allograft antibody-mediated injury","volume":"27","author":"Lefaucheur","year":"2016","journal-title":"J Am Soc Nephrol."},{"key":"10.1111\/ajt.15340_bib26","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1111\/ajt.12317","article-title":"Microcirculation lesions alone are not reliable for identifying antibody-mediated rejection","volume":"13","author":"Halloran","year":"2013","journal-title":"Am J Transplant."},{"issue":"5","key":"10.1111\/ajt.15340_bib27","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1111\/j.1600-6143.2011.03931.x","article-title":"A new diagnostic algorithm for antibody-mediated microcirculation inflammation in kidney transplants","volume":"12","author":"Sis","year":"2012","journal-title":"Am J Transplant."},{"key":"10.1111\/ajt.15340_bib28","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/ki.2015.99","article-title":"Peritubular capillaritis in the renal allograft takes center stage","volume":"88","author":"Racusen","year":"2015","journal-title":"Kidney Int."},{"key":"10.1111\/ajt.15340_bib29","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/ki.2015.276","article-title":"Clinical and molecular significance of microvascular inflammation in transplant kidney biopsies","volume":"89","author":"Gupta","year":"2016","journal-title":"Kidney Int."},{"issue":"4","key":"10.1111\/ajt.15340_bib30","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.kint.2018.03.015","article-title":"Complement-binding anti-HLA antibodies are independent predictors of response to treatment in kidney recipients with antibody-mediated rejection","volume":"94","author":"Viglietti","year":"2018","journal-title":"Kidney Int."},{"key":"10.1111\/ajt.15340_bib31","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.kint.2016.10.040","article-title":"Differences in pathologic features and graft outcomes in antibody-mediated rejection of renal allografts due to persistent\/recurrent versus de novo donor-specific antibodies","volume":"91","author":"Haas","year":"2017","journal-title":"Kidney Int."},{"key":"10.1111\/ajt.15340_bib32","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1111\/ajt.14161","article-title":"The value of protocol biopsies to identify patients with de novo donor-specific antibody at high risk for allograft loss","volume":"17","author":"Schinstock","year":"2017","journal-title":"Am J Transplant."},{"key":"10.1111\/ajt.15340_bib33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/TP.0b013e31827a19cc","article-title":"Consensus guidelines on the testing and clinical management issues associated with HLA and non-HLA antibodies in transplantation","volume":"95","author":"Tait","year":"2013","journal-title":"Transplantation."},{"key":"10.1111\/ajt.15340_bib34","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/ki.2012.190","article-title":"Donor-specific HLA-DQ antibodies may contribute to poor graft outcome after renal transplantation","volume":"82","author":"DeVos","year":"2012","journal-title":"Kidney Int."},{"key":"10.1111\/ajt.15340_bib35","doi-asserted-by":"crossref","first-page":"e3094","DOI":"10.1097\/MD.0000000000003094","article-title":"Clinical significance of HLA-DQ antibodies in the development of chronic antibody-mediated rejection and allograft failure in kidney transplant recipients","volume":"95","author":"Lee","year":"2016","journal-title":"Medicine (Baltimore)."},{"key":"10.1111\/ajt.15340_bib36","doi-asserted-by":"crossref","first-page":"5201098","DOI":"10.1155\/2017\/5201098","article-title":"From humoral theory to performant risk stratification in kidney transplantation","volume":"2017","author":"Lefaucheur","year":"2017","journal-title":"J Immunol Res."}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.15340","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.15340","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajt.15340","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S160061352209219X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S160061352209219X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.15340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:25:03Z","timestamp":1761629103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S160061352209219X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S160061352209219X"],"URL":"https:\/\/doi.org\/10.1111\/ajt.15340","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Markers of graft microvascular endothelial injury may identify harmful donor-specific anti-HLA antibodies and predict kidney allograft loss","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.15340","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}