{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:41:17Z","timestamp":1791859277682,"version":"4.3.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006396","name":"Alexion Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1111\/ajt.15364","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T21:14:13Z","timestamp":1553030053000},"page":"2876-2888","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":143,"title":["Safety and efficacy of eculizumab in the prevention of antibody-mediated rejection in living-donor kidney transplant recipients requiring desensitization therapy: A randomized trial"],"prefix":"10.1016","volume":"19","author":[{"given":"William H.","family":"Marks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizam","family":"Mamode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Stegall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd E.","family":"Ratner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn D.","family":"Cornell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajda T.","family":"Rowshani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Colvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Dain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Boice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Glotz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1111\/ajt.15364_bib1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/ajt.12589","article-title":"Diagnosis and management of antibody-mediated rejection: current status and novel approaches","volume":"14","author":"Djamali","year":"2014","journal-title":"Am J Transplant."},{"issue":"8","key":"10.1111\/ajt.15364_bib2","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.2215\/CJN.02940311","article-title":"Incompatible live-donor kidney transplantation in the United States: results of a national survey","volume":"6","author":"Garonzik Wang","year":"2011","journal-title":"Clin J Am Soc Nephrol."},{"issue":"15","key":"10.1111\/ajt.15364_bib3","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1001\/jama.293.15.1883","article-title":"Kidney paired donation and optimizing the use of live donor organs","volume":"293","author":"Segev","year":"2005","journal-title":"JAMA."},{"issue":"8","key":"10.1111\/ajt.15364_bib4","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1681\/ASN.2009101065","article-title":"Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation","volume":"21","author":"Lefaucheur","year":"2010","journal-title":"J Am Soc Nephrol."},{"issue":"10","key":"10.1111\/ajt.15364_bib5","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1111\/j.1600-6143.2011.03640.x","article-title":"Revisiting traditional risk factors for rejection and graft loss after kidney transplantation","volume":"11","author":"Dunn","year":"2011","journal-title":"Am J Transplant."},{"issue":"12","key":"10.1111\/ajt.15364_bib6","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1681\/ASN.2012070664","article-title":"Donor-specific antibodies adversely affect kidney allograft outcomes","volume":"23","author":"Mohan","year":"2012","journal-title":"J Am Soc Nephrol."},{"issue":"12","key":"10.1111\/ajt.15364_bib7","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1111\/j.1600-6143.2008.02441.x","article-title":"Alloantibody levels and acute humoral rejection early after positive crossmatch kidney transplantation","volume":"8","author":"Burns","year":"2008","journal-title":"Am J Transplant."},{"issue":"11","key":"10.1111\/ajt.15364_bib8","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nrneph.2012.212","article-title":"The role of complement in antibody-mediated rejection in kidney transplantation","volume":"8","author":"Stegall","year":"2012","journal-title":"Nat Rev Nephrol."},{"issue":"4","key":"10.1111\/ajt.15364_bib9","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.smim.2011.08.021","article-title":"Humoral immunity and antibody-mediated rejection in solid organ transplantation","volume":"23","author":"Montgomery","year":"2011","journal-title":"Semin Immunol."},{"key":"10.1111\/ajt.15364_bib10","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3389\/fmed.2017.00066","article-title":"Complement in kidney transplantation","volume":"4","author":"Cernoch","year":"2017","journal-title":"Front Med (Lausanne)."},{"issue":"10","key":"10.1111\/ajt.15364_bib11","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1111\/j.1600-6143.2011.03686.x","article-title":"Systematic review: kidney transplantation compared with dialysis in clinically relevant outcomes","volume":"11","author":"Tonelli","year":"2011","journal-title":"Am J Transplant."},{"issue":"2","key":"10.1111\/ajt.15364_bib12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/ajt.12982","article-title":"Quantifying renal allograft loss following early antibody-mediated rejection","volume":"15","author":"Orandi","year":"2015","journal-title":"Am J Transplant."},{"issue":"1","key":"10.1111\/ajt.15364_bib13","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.trre.2008.08.004","article-title":"Antibody-mediated rejection: treatment alternatives and outcomes","volume":"23","author":"Singh","year":"2009","journal-title":"Transplant Rev (Orlando)."},{"issue":"4","key":"10.1111\/ajt.15364_bib14","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.humimm.2016.01.018","article-title":"Current outcomes of chronic active antibody mediated rejection - a large single center retrospective review using the updated BANFF 2013 criteria","volume":"77","author":"Redfield","year":"2016","journal-title":"Hum Immunol."},{"issue":"2","key":"10.1111\/ajt.15364_bib15","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1600-6143.2007.02072.x","article-title":"Clinical relevance of preformed HLA donor-specific antibodies in kidney transplantation","volume":"8","author":"Lefaucheur","year":"2008","journal-title":"Am J Transplant."},{"issue":"10","key":"10.1111\/ajt.15364_bib16","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/tri.12621","article-title":"Difference in outcomes after antibody-mediated rejection between abo-incompatible and positive cross-match transplantations","volume":"28","author":"Couzi","year":"2015","journal-title":"Transpl Int."},{"issue":"12","key":"10.1111\/ajt.15364_bib17","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1097\/01.ASN.0000145878.92906.9F","article-title":"Evaluation of intravenous immunoglobulin as an agent to lower allosensitization and improve transplantation in highly sensitized adult patients with end-stage renal disease: report of the NIH IG02 trial","volume":"15","author":"Jordan","year":"2004","journal-title":"J Am Soc Nephrol."},{"issue":"6","key":"10.1111\/ajt.15364_bib18","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1097\/00007890-200009270-00006","article-title":"Plasmapheresis and intravenous immune globulin provides effective rescue therapy for refractory humoral rejection and allows kidneys to be successfully transplanted into cross-match-positive recipients","volume":"70","author":"Montgomery","year":"2000","journal-title":"Transplantation."},{"issue":"10","key":"10.1111\/ajt.15364_bib19","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1097\/TP.0000000000001650","article-title":"Long-term outcomes of kidney transplantation in patients with high levels of preformed DSA: the Necker high-risk transplant program","volume":"101","author":"Amrouche","year":"2017","journal-title":"Transplantation."},{"issue":"4","key":"10.1111\/ajt.15364_bib20","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/TP.0000000000002049","article-title":"The treatment of antibody-mediated rejection in kidney transplantation: an updated systematic review and meta-analysis","volume":"102","author":"Wan","year":"2018","journal-title":"Transplantation."},{"issue":"2","key":"10.1111\/ajt.15364_bib21","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/TP.0b013e3181919a16","article-title":"Living donor kidney transplantation across positive crossmatch: the University of Illinois at Chicago experience","volume":"87","author":"Thielke","year":"2009","journal-title":"Transplantation."},{"issue":"4","key":"10.1111\/ajt.15364_bib22","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1056\/NEJMoa1012376","article-title":"Desensitization in HLA-incompatible kidney recipients and survival","volume":"365","author":"Montgomery","year":"2011","journal-title":"N Engl J Med."},{"issue":"10","key":"10.1111\/ajt.15364_bib23","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1056\/NEJMoa1508380","article-title":"Survival benefit with kidney transplants from HLA-incompatible live donors","volume":"374","author":"Orandi","year":"2016","journal-title":"N Engl J Med."},{"issue":"10070","key":"10.1111\/ajt.15364_bib24","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0140-6736(16)31595-1","article-title":"Post-listing survival for highly sensitised patients on the UK kidney transplant waiting list: a matched cohort analysis","volume":"389","author":"Manook","year":"2017","journal-title":"Lancet."},{"key":"10.1111\/ajt.15364_bib25","doi-asserted-by":"crossref","first-page":"6804678","DOI":"10.1155\/2017\/6804678","article-title":"Desensitization: overcoming the immunologic barriers to transplantation","volume":"2017","author":"Sethi","year":"2017","journal-title":"J Immunol Res."},{"issue":"11","key":"10.1111\/ajt.15364_bib26","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1111\/j.1600-6143.2011.03757.x","article-title":"Terminal complement inhibition decreases antibody-mediated rejection in sensitized renal transplant recipients","volume":"11","author":"Stegall","year":"2011","journal-title":"Am J Transplant."},{"issue":"1","key":"10.1111\/ajt.15364_bib27","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1600-6143.2008.02451.x","article-title":"The use of antibody to complement protein C5 for salvage treatment of severe antibody-mediated rejection","volume":"9","author":"Locke","year":"2009","journal-title":"Am J Transplant."},{"issue":"4","key":"10.1111\/ajt.15364_bib28","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1600-6143.2008.02159.x","article-title":"Banff 07 classification of renal allograft pathology: updates and future directions","volume":"8","author":"Solez","year":"2008","journal-title":"Am J Transplant."},{"issue":"2","key":"10.1111\/ajt.15364_bib29","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1600-6143.2005.01178.x","article-title":"A comparison of plasmapheresis versus high-dose IVIG desensitization in renal allograft recipients with high levels of donor specific alloantibody","volume":"6","author":"Stegall","year":"2006","journal-title":"Am J Transplant."},{"issue":"1","key":"10.1111\/ajt.15364_bib30","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/TP.0b013e318176ae2c","article-title":"Renal transplantation in patients with positive lymphocytotoxicity crossmatches: one center\u2019s experience","volume":"86","author":"Magee","year":"2008","journal-title":"Transplantation."},{"issue":"9","key":"10.1111\/ajt.15364_bib31","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/TP.0b013e3181d21e7f","article-title":"Use of intravenous immune globulin and rituximab for desensitization of highly HLA-sensitized patients awaiting kidney transplantation","volume":"89","author":"Vo","year":"2010","journal-title":"Transplantation."},{"issue":"Suppl 4","key":"10.1111\/ajt.15364_bib32","first-page":"39","article-title":"Terminal complement inhibition decreases early acute humoral rejection in sensitized renal transplant recipients [abstract 1]","volume":"10","author":"Stegall","year":"2010","journal-title":"Am J Transplant."},{"issue":"370","key":"10.1111\/ajt.15364_bib33","first-page":"386","article-title":"Small-sample confidence intervals for p1\u2013 p2 and p1\/p2 in 2 \u00d7 2 contingency tables","volume":"75","author":"Santner","year":"1980","journal-title":"J Am Stat Assoc."},{"key":"10.1111\/ajt.15364_bib34","series-title":"Statistical Methods for Research Workers","author":"Fisher","year":"1925"},{"issue":"1","key":"10.1111\/ajt.15364_bib35","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics."},{"issue":"4","key":"10.1111\/ajt.15364_bib36","doi-asserted-by":"crossref","first-page":"922","DOI":"10.2215\/CJN.08140910","article-title":"Desensitization protocols and their outcome","volume":"6","author":"Marfo","year":"2011","journal-title":"Clin J Am Soc Nephrol."},{"key":"10.1111\/ajt.15364_bib37","unstructured":"Glotz D, Russ G, Rostaing L, et al. Prevention of acute antibody-mediated rejection in sensitized deceased-donor kidney transplant recipients: 1-year outcomes presented at American Society of Nephrology, Kidney Week November 3-8, 2015, San Diego. 2015."},{"issue":"4","key":"10.1111\/ajt.15364_bib38","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.1600-6143.2007.02137.x","article-title":"Peritubular capillaritis in renal allografts: prevalence, scoring system, reproducibility and clinicopathological correlates","volume":"8","author":"Gibson","year":"2008","journal-title":"Am J Transplant."},{"issue":"11","key":"10.1111\/ajt.15364_bib39","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1111\/j.1600-6143.2010.03261.x","article-title":"A critical appraisal of methods to grade transplant glomerulitis in renal allograft biopsies","volume":"10","author":"Batal","year":"2010","journal-title":"Am J Transplant."},{"key":"10.1111\/ajt.15364_bib40","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/tri.13340","article-title":"A method to reduce variability in scoring antibody-mediated rejection in renal allografts: implications for clinical trials - a retrospective study","volume":"32","author":"Smith","year":"2018","journal-title":"Transpl Int."},{"issue":"6","key":"10.1111\/ajt.15364_bib41","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/j.1600-6143.2011.03964.x","article-title":"Intragraft gene expression in positive crossmatch kidney allografts: ongoing inflammation mediates chronic antibody-mediated injury","volume":"12","author":"Dean","year":"2012","journal-title":"Am J Transplant."},{"issue":"3","key":"10.1111\/ajt.15364_bib42","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.1600-6143.2009.02985.x","article-title":"Baseline donor-specific antibody levels and outcomes in positive crossmatch kidney transplantation","volume":"10","author":"Gloor","year":"2010","journal-title":"Am J Transplant."},{"issue":"23","key":"10.1111\/ajt.15364_bib43","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1056\/NEJMoa1208981","article-title":"Terminal complement inhibitor eculizumab in atypical hemolytic\u2013uremic syndrome","volume":"368","author":"Legendre","year":"2013","journal-title":"N Engl J Med."},{"issue":"5","key":"10.1111\/ajt.15364_bib44","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/ki.2014.423","article-title":"Efficacy and safety of eculizumab in atypical hemolytic uremic syndrome from 2-year extensions of phase 2 studies","volume":"87","author":"Licht","year":"2015","journal-title":"Kidney Int."},{"issue":"12","key":"10.1111\/ajt.15364_bib45","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1056\/NEJMoa061648","article-title":"The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria","volume":"355","author":"Hillmen","year":"2006","journal-title":"N Engl J Med."},{"issue":"13","key":"10.1111\/ajt.15364_bib46","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1056\/NEJMoa1302506","article-title":"Complement-binding anti-HLA antibodies and kidney-allograft survival","volume":"369","author":"Loupy","year":"2013","journal-title":"N Engl J Med."},{"issue":"2","key":"10.1111\/ajt.15364_bib47","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1681\/ASN.2017050589","article-title":"Complement-activating anti-HLA antibodies in kidney transplantation: allograft gene expression profiling and response to treatment","volume":"29","author":"Lefaucheur","year":"2018","journal-title":"J Am Soc Nephrol."},{"issue":"5","key":"10.1111\/ajt.15364_bib48","doi-asserted-by":"crossref","first-page":"e1002572","DOI":"10.1371\/journal.pmed.1002572","article-title":"Complement-activating donor-specific anti-HLA antibodies and solid organ transplant survival: a systematic review and meta-analysis","volume":"15","author":"Bouquegneau","year":"2018","journal-title":"PLoS Med."}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.15364","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.15364","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajt.15364","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522092723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522092723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.15364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:25:33Z","timestamp":1761629133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522092723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S1600613522092723"],"URL":"https:\/\/doi.org\/10.1111\/ajt.15364","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and efficacy of eculizumab in the prevention of antibody-mediated rejection in living-donor kidney transplant recipients requiring desensitization therapy: A randomized trial","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.15364","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}