{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:39:20Z","timestamp":1792521560090,"version":"4.5.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":1012,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1111\/ajt.15584","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:23:09Z","timestamp":1566865389000},"page":"553-563","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Belatacept-based immunosuppression: A calcineurin inhibitor-sparing regimen in heart transplant recipients"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3113-7301","authenticated-orcid":false,"given":"Manon","family":"Launay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"Guitard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Dorent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoann","family":"Prevot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Prion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Beaumont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Kably","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucien","family":"Lecuyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane M.","family":"Billaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Guillemain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1111\/ajt.15584_bib1","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1159\/000351648","article-title":"Calcineurin inhibitor nephrotoxicity: a review and perspective of the evidence","volume":"37","author":"Issa","year":"2013","journal-title":"Am J Nephrol."},{"issue":"5","key":"10.1111\/ajt.15584_bib2","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.immuni.2016.04.020","article-title":"CD28 costimulation: from mechanism to therapy","volume":"44","author":"Esensten","year":"2016","journal-title":"Immunity."},{"key":"10.1111\/ajt.15584_bib3","unstructured":"Bristol-Myers Squibb. Summary of Product Characteristics of Nulojix. http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Product_Information\/human\/002098\/WC500108355.pdf. Accessed July 11, 2018."},{"issue":"8","key":"10.1111\/ajt.15584_bib4","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1056\/NEJMoa050085","article-title":"Costimulation blockade with belatacept in renal transplantation","volume":"353","author":"Vincenti","year":"2005","journal-title":"N Engl J Med."},{"issue":"2","key":"10.1111\/ajt.15584_bib5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/01.TP.0000438635.44461.2e","article-title":"Safety of belatacept bridging immunosuppression in hepatitis C-positive liver transplant recipients with renal dysfunction","volume":"97","author":"LaMattina","year":"2014","journal-title":"Transplantation."},{"issue":"8","key":"10.1111\/ajt.15584_bib6","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1111\/ajt.12810","article-title":"Belatacept-based immunosuppression in de novo liver transplant recipients: 1-year experience from a phase II randomized study","volume":"14","author":"Klintmalm","year":"2014","journal-title":"Am J Transplant."},{"issue":"1","key":"10.1111\/ajt.15584_bib7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/TP.0000000000001873","article-title":"Maintenance belatacept-based immunosuppression in lung transplantation recipients who failed calcineurin inhibitors","volume":"102","author":"Iasella","year":"2018","journal-title":"Transplantation."},{"issue":"4","key":"10.1111\/ajt.15584_bib8","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/tri.12731","article-title":"Belatacept for renal rescue in lung transplant patients","volume":"29","author":"Timofte","year":"2016","journal-title":"Transpl Int."},{"issue":"11","key":"10.1111\/ajt.15584_bib9","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.healun.2005.03.019","article-title":"Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection","volume":"24","author":"Stewart","year":"2005","journal-title":"J Heart Lung Transplant."},{"key":"10.1111\/ajt.15584_bib10","unstructured":"Agence de la biom\u00e9decine - Le rapport annuel m\u00e9dical et scientifique 2017. https:\/\/www.agencebiomedecine.fr\/annexes\/bilan2017\/donnees\/organes\/03-coeur\/synthese.htm. Accessed July 2, 2019."},{"issue":"7","key":"10.1111\/ajt.15584_bib11","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1097\/TP.0000000000000404","article-title":"Belatacept maintenance in a heart transplant recipient","volume":"98","author":"Enderby","year":"2014","journal-title":"Transplantation."},{"key":"10.1111\/ajt.15584_bib12","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1111\/ajt.15003","article-title":"Belatacept rescue for delayed kidney allograft function in a patient with previous combined heart-liver transplant","volume":"18","author":"Kumar","year":"2018","journal-title":"Am J Transpl."},{"issue":"6","key":"10.1111\/ajt.15584_bib13","doi-asserted-by":"crossref","first-page":"e255","DOI":"10.1097\/TP.0000000000002153","article-title":"Fulminant acute respiratory distress syndrome after calcineurin inhibitor-belatacept conversion in a lung transplant recipient","volume":"102","author":"Brugi\u00e8re","year":"2018","journal-title":"Transplantation."},{"issue":"4","key":"10.1111\/ajt.15584_bib14","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1111\/ajt.13613","article-title":"CD57(+) CD4 T cells underlie belatacept-resistant allograft rejection","volume":"16","author":"Espinosa","year":"2016","journal-title":"Am J Transplant."},{"issue":"1","key":"10.1111\/ajt.15584_bib15","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.transproceed.2016.01.003","article-title":"invasive tracheobronchial aspergillosis in a lung transplant recipient receiving belatacept as salvage maintenance immunosuppression: a case report","volume":"48","author":"Haidar","year":"2016","journal-title":"Transplant Proc."},{"key":"10.1111\/ajt.15584_bib16","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1097\/TP.0000000000002291","article-title":"Belatacept in solid organ transplant: review of current literature across transplant types","volume":"102","author":"Perez","year":"2018","journal-title":"Transplantation."},{"issue":"1","key":"10.1111\/ajt.15584_bib17","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000346346","article-title":"Burkitt\u2019s lymphoma presenting as late-onset posttransplant lymphoproliferative disorder following kidney and pancreas transplantation: case report and review of the literature","volume":"6","author":"Naik","year":"2013","journal-title":"Case Rep Oncol."},{"issue":"1","key":"10.1111\/ajt.15584_bib18","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/ajt.13886","article-title":"Efficacy and safety outcomes of extended criteria donor kidneys by subtype: subgroup analysis of BENEFIT-EXT at 7 years after transplant","volume":"17","author":"Florman","year":"2017","journal-title":"Am J Transplant."},{"issue":"7","key":"10.1111\/ajt.15584_bib19","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1111\/ajt.14738","article-title":"Posttransplant reduction in preexisting donor-specific antibody levels after belatacept-versus cyclosporine-based immunosuppression: post hoc analyses of BENEFIT and BENEFIT-EXT","volume":"18","author":"Bray","year":"2018","journal-title":"Am J Transplant."},{"issue":"9","key":"10.1111\/ajt.15584_bib20","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1097\/TP.0000000000002192","article-title":"Conversion to belatacept in maintenance kidney transplant patients: a retrospective multicenter European study","volume":"102","author":"Darres","year":"2018","journal-title":"Transplantation."},{"issue":"11","key":"10.1111\/ajt.15584_bib21","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1111\/ctr.12843","article-title":"Long-term outcome after early cyclosporine withdrawal in kidney transplantation: ten years after","volume":"30","author":"Tabibzadeh","year":"2016","journal-title":"Clin Transpl."}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.15584","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.15584","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajt.15584","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522222084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522222084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.15584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:25:33Z","timestamp":1761629133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522222084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S1600613522222084"],"URL":"https:\/\/doi.org\/10.1111\/ajt.15584","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Belatacept-based immunosuppression: A calcineurin inhibitor-sparing regimen in heart transplant recipients","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.15584","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}