{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:25:28Z","timestamp":1793424328512,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":1012,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1111\/ajt.15614","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T13:33:47Z","timestamp":1569332027000},"page":"451-462","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Oral fosfomycin for the treatment of lower urinary tract infections among kidney transplant recipients\u2014Results of a Spanish multicenter cohort"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5333-7529","authenticated-orcid":false,"given":"Francisco","family":"L\u00f3pez-Medrano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Tiago","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-8001","authenticated-orcid":false,"given":"Mario","family":"Fern\u00e1ndez-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Orig\u00fcen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Calvo-Cano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Luna-Huerta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza","family":"Merino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domingo","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Jironda-Gallegos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Escudero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Gioia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Roca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Cordero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dar\u00edo","family":"Janeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"S\u00e1nchez-Sobrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Milagro","family":"Montero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Redondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Candel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"P\u00e9rez-Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Armi\u00f1anzas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Gonz\u00e1lez-Rico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Carmen","family":"Fari\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Rodrigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Loeches","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda O.","family":"L\u00f3pez-Oliva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Montejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Lauzurica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Horcajada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Pascual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0238-1364","authenticated-orcid":false,"given":"Amado","family":"Andr\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Aguado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/ajt.15614_bib1","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1093\/ndt\/gfq531","article-title":"Acute graft pyelonephritis in renal transplant recipients: incidence, risk factors and long-term outcome","volume":"26","author":"Fiorante","year":"2011","journal-title":"Nephrol Dial Transplant."},{"key":"10.1111\/ajt.15614_bib2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/tid.12547","article-title":"Progressive increase of resistance in Enterobacteriaceae urinary isolates from kidney transplant recipients over the past decade: narrowing of the therapeutic options","volume":"18","author":"Orig\u00fcen","year":"2016","journal-title":"Transpl Infect Dis."},{"key":"10.1111\/ajt.15614_bib3","unstructured":"US Food and Drug Administration. Drug safety communications. FDA warns about increased risk of ruptures or tears in the aorta blood vessel with fluoroquinolone antibiotics in certain patients. https:\/\/www.fda.gov\/media\/119532\/download. Accessed July 26, 2019."},{"key":"10.1111\/ajt.15614_bib4","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1001\/jamainternmed.2015.5389","article-title":"Risk of aortic dissection and aortic aneurysm in patients taking oral fluoroquinolone","volume":"175","author":"Lee","year":"2015","journal-title":"JAMA Intern Med."},{"key":"10.1111\/ajt.15614_bib5","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.jacc.2018.06.067","article-title":"Oral fluoroquinolone and the risk of aortic dissection","volume":"72","author":"Lee","year":"2018","journal-title":"J Am Coll Cardiol."},{"key":"10.1111\/ajt.15614_bib6","doi-asserted-by":"crossref","unstructured":"Goldman JD, Julian K. Urinary tract infections in solid organ transplant recipients: guidelines from the American Society of Transplantation Infectious Diseases Community of Practice [published online ahead of print February 21, 2019]. Clin Transplant. https:\/\/doi.org\/10.1111\/ctr.13507.","DOI":"10.1111\/ctr.13507"},{"key":"10.1111\/ajt.15614_bib7","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1126\/science.166.3901.122","article-title":"Phosphonomycin, a new antibiotic produced by strains of streptomyces","volume":"166","author":"Hendlin","year":"1969","journal-title":"Science."},{"key":"10.1111\/ajt.15614_bib8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1128\/CMR.00068-15","article-title":"Fosfomycin","volume":"29","author":"Falagas","year":"2016","journal-title":"Clin Microbiol Rev."},{"key":"10.1111\/ajt.15614_bib9","doi-asserted-by":"crossref","first-page":"2082693","DOI":"10.1155\/2016\/2082693","article-title":"Fosfomycin: a first-line oral therapy for acute uncomplicated cystitis","volume":"2016","author":"Zhanel","year":"2016","journal-title":"Can J Infect Dis Med Microbiol."},{"key":"10.1111\/ajt.15614_bib10","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1128\/AAC.32.6.938","article-title":"Comparative pharmacokinetics of tromethamine fosfomycin and calcium fosfomycin in young and elderly adults","volume":"32","author":"Borsa","year":"1988","journal-title":"Antimicrob Agents Chemother."},{"key":"10.1111\/ajt.15614_bib11","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1007\/s40265-013-0143-y","article-title":"Fosfomycin trometamol: a review of its use as a single-dose oral treatment for patients with acute lower urinary tract infections and pregnant women with asymptomatic bacteriuria","volume":"73","author":"Keating","year":"2013","journal-title":"Drugs."},{"key":"10.1111\/ajt.15614_bib12","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s10096-007-0456-4","article-title":"Antimicrobial susceptibility of multidrug-resistant Gram negative bacteria to fosfomycin","volume":"27","author":"Falagas","year":"2008","journal-title":"Eur J Clin Microbiol Infect Dis."},{"key":"10.1111\/ajt.15614_bib13","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1128\/AAC.00721-09","article-title":"Susceptibility of urinary tract bacteria to fosfomycin","volume":"53","author":"Maraki","year":"2009","journal-title":"Antimicrob Agents Chemother."},{"key":"10.1111\/ajt.15614_bib14","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.1128\/AAC.00402-12","article-title":"Experience with fosfomycin for treatment of urinary tract infections due to multidrug-resistant organisms","volume":"56","author":"Neuner","year":"2012","journal-title":"Antimicrob Agents Chemother."},{"key":"10.1111\/ajt.15614_bib15","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1097\/TP.0b013e318298dd26","article-title":"The use of fosfomycin to treat urinary tract infections in kidney transplant recipients","volume":"96","author":"Reid","year":"2013","journal-title":"Transplantation."},{"key":"10.1111\/ajt.15614_bib16","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/phar.1924","article-title":"Fosfomycin for the treatment of cystitis in the abdominal solid organ transplant population","volume":"37","author":"Loethen","year":"2017","journal-title":"Pharmacotherapy."},{"key":"10.1111\/ajt.15614_bib17","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1097\/TP.0000000000002427","article-title":"Fosfomycin-trometamol for urinary tract infections in kidney transplant recipients","volume":"103","author":"ten Doesschate","year":"2019","journal-title":"Transplantation."},{"issue":"10","key":"10.1111\/ajt.15614_bib18","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1093\/cid\/ciy1121","article-title":"Clinical practice guideline for the management of asymptomatic bacteriuria: 2019 Update by the Infectious Diseases Society of America","volume":"68","author":"Nicolle","year":"2019","journal-title":"Clin Infect Dis."},{"issue":"Suppl","key":"10.1111\/ajt.15614_bib19","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ijantimicag.2011.09.009","article-title":"Critical review of current definitions of urinary tract infections and proposal of an EAU\/ESIU classification system","volume":"38","author":"Johansen","year":"2011","journal-title":"Int J Antimicrob Agents."},{"key":"10.1111\/ajt.15614_bib20","unstructured":"The European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint tables for interpretation of MICs and zone diameters. Version 9.0, 2019. http:\/\/www.eucast.org. Accessed July 26, 2019."},{"issue":"Suppl 1","key":"10.1111\/ajt.15614_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.37201\/req\/s01.00.2021","article-title":"New perspectives for reassessing fosfomycin: applicability in current clinical practice","volume":"32","author":"Candel","year":"2019","journal-title":"Rev Esp Quimioter."},{"key":"10.1111\/ajt.15614_bib22","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1086\/650482","article-title":"Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America","volume":"50","author":"Hooton","year":"2010","journal-title":"Clin Infect Dis."},{"key":"10.1111\/ajt.15614_bib23","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin Microbiol Infect."},{"key":"10.1111\/ajt.15614_bib24","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/1060028017710252","article-title":"Fosfomycin tromethamine for the treatment of cystitis in abdominal solid organ transplant recipients with renal dysfunction","volume":"51","author":"Kerstenetzky","year":"2017","journal-title":"Ann Pharmacother."},{"key":"10.1111\/ajt.15614_bib25","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1093\/jac\/dkw178","article-title":"Treatment of MDR urinary tract infections with oral fosfomycin: a retrospective analysis","volume":"71","author":"Seroy","year":"2016","journal-title":"J Antimicrob Chemother."},{"key":"10.1111\/ajt.15614_bib26","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ijantimicag.2014.05.020","volume":"44","author":"Kresken","year":"2014","journal-title":"Int J Antimicrob Agents."},{"key":"10.1111\/ajt.15614_bib27","doi-asserted-by":"crossref","unstructured":"van Driel AA, Notermans DW, Meima A, et al. Antibiotic resistance of Escherichia coli isolated from uncomplicated UTI in general practice patients over a 10-year period. Eur J Clin Microbiol Infect Dis. 2019.","DOI":"10.1007\/s10096-019-03655-3"},{"key":"10.1111\/ajt.15614_bib28","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1128\/JCM.03484-13","article-title":"Fosfomycin susceptibility in carbapenem-resistant Enterobacteriaceae from Germany","volume":"52","author":"Kaase","year":"2014","journal-title":"J Clin Microbiol."},{"key":"10.1111\/ajt.15614_bib29","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s10156-010-0079-z","article-title":"A randomized comparative study of single-dose fosfomycin and 5-day ciprofloxacin in female patients with uncomplicated lower urinary tract infections","volume":"16","author":"Ceran","year":"2010","journal-title":"J Infect Chemother."},{"key":"10.1111\/ajt.15614_bib30","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.4065\/80.10.1298","article-title":"Chronic nitrofurantoin-induced lung disease","volume":"80","author":"Mendez","year":"2005","journal-title":"Mayo Clin Proc."},{"key":"10.1111\/ajt.15614_bib31","doi-asserted-by":"crossref","first-page":"43035","DOI":"10.1038\/srep43035","article-title":"Long-term use of ceftriaxone sodium induced changes in gut microbiota and immune system","volume":"7","author":"Guo","year":"2017","journal-title":"Sci Rep."},{"key":"10.1111\/ajt.15614_bib32","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s40168-016-0187-9","article-title":"Microbial diversity in individuals and their household contacts following typical antibiotic courses","volume":"4","author":"Abeles","year":"2016","journal-title":"Microbiome."},{"key":"10.1111\/ajt.15614_bib33","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1093\/jac\/dkx043","article-title":"Ecological impact of ciprofloxacin on commensal enterococci in healthy volunteers","volume":"72","author":"de Lastours","year":"2017","journal-title":"J Antimicrob Chemother."},{"key":"10.1111\/ajt.15614_bib34","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/BF01643751","article-title":"Influence of fosfomycin on the intestinal and pharyngeal flora of man","volume":"19","author":"Knothe","year":"1991","journal-title":"Infection."},{"key":"10.1111\/ajt.15614_bib35","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ijantimicag.2018.09.013","article-title":"Resistance to fosfomycin: mechanisms, frequency and clinical consequences","volume":"53","author":"Falagas","year":"2019","journal-title":"Int J Antimicrob Agents."},{"key":"10.1111\/ajt.15614_bib36","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cmi.2016.12.005","article-title":"Intravenous fosfomycin-back to the future. Systematic review and meta-analysis of the clinical literature","volume":"23","author":"Grabein","year":"2017","journal-title":"Clin Microbiol Infect."},{"key":"10.1111\/ajt.15614_bib37","doi-asserted-by":"crossref","first-page":"e007363","DOI":"10.1136\/bmjopen-2014-007363","article-title":"Fosfomycin versus meropenem in bacteraemic urinary tract infections caused by extended-spectrum beta-lactamase-producing Escherichia coli (FOREST): study protocol for an investigator-driven randomised controlled trial","volume":"5","author":"Rosso-Fern\u00e1ndez","year":"2015","journal-title":"BMJ Open."},{"key":"10.1111\/ajt.15614_bib38","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ijantimicag.2013.09.010","article-title":"Outcomes of critically ill intensive care unit patients treated with fosfomycin for infections due to pandrug-resistant and extensively drug-resistant carbapenemase-producing Gram-negative bacteria","volume":"43","author":"Pontikis","year":"2014","journal-title":"Int J Antimicrob Agents."},{"key":"10.1111\/ajt.15614_bib39","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1517\/13543780902967624","article-title":"Fosfomycin for the treatment of infections caused by Gram-positive cocci with advanced antimicrobial drug resistance: a review of microbiological, animal and clinical studies","volume":"18","author":"Falagas","year":"2009","journal-title":"Expert Opin Investig Drugs."},{"key":"10.1111\/ajt.15614_bib40","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1093\/cid\/ciw118","article-title":"Implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America","volume":"62","author":"Barlam","year":"2016","journal-title":"Clin Infect Dis."},{"key":"10.1111\/ajt.15614_bib41","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1186\/s12879-016-1888-1","article-title":"Oral fosfomycin for treatment of urinary tract infection: a retrospective cohort study","volume":"16","author":"Matthews","year":"2016","journal-title":"BMC Infect Dis."},{"key":"10.1111\/ajt.15614_bib42","article-title":"Experience with fosfomycin in the treatment of complicated urinary tract infections caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae","volume":"6","author":"Bielen","year":"2019","journal-title":"Ther Adv Infect Dis."}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.15614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.15614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajt.15614","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522221984?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522221984?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.15614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:25:50Z","timestamp":1761629150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522221984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S1600613522221984"],"URL":"https:\/\/doi.org\/10.1111\/ajt.15614","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral fosfomycin for the treatment of lower urinary tract infections among kidney transplant recipients\u2014Results of a Spanish multicenter cohort","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.15614","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}