{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:47Z","timestamp":1787013827027,"version":"build-2736575974"},"reference-count":71,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":992,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001078","name":"Diabetes Research Institute Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001078","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK100654"],"award-info":[{"award-number":["R01DK100654"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AI102456"],"award-info":[{"award-number":["U01AI102456"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01A1089556"],"award-info":[{"award-number":["P01A1089556"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1111\/ajt.15643","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T15:39:16Z","timestamp":1570635556000},"page":"689-700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Transplantation of PEGylated islets enhances therapeutic efficacy in a diabetic nonhuman primate model"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0573-0646","authenticated-orcid":false,"given":"Cherie L.","family":"Stabler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime A.","family":"Giraldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7817-9387","authenticated-orcid":false,"given":"Dora M.","family":"Berman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerim M.","family":"Gatt\u00e1s-Asfura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A.","family":"Willman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Rabassa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Geary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldo","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman M.","family":"Kenyon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3157-339X","authenticated-orcid":false,"given":"Norma S.","family":"Kenyon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1111\/ajt.15643_bib1","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.2337\/dc17-1779","article-title":"Improved health-related quality of life in a phase 3 islet transplantation trial in type 1 diabetes complicated by severe hypoglycemia","volume":"41","author":"Foster","year":"2018","journal-title":"Diabetes Care."},{"issue":"4","key":"10.1111\/ajt.15643_bib2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","article-title":"Islet transplantation in seven patients with Type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen","volume":"343","author":"Shapiro","year":"2000","journal-title":"N Engl J Med."},{"issue":"7","key":"10.1111\/ajt.15643_bib3","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.2337\/diabetes.54.7.2060","article-title":"Five-year follow-up after clinical islet transplantation","volume":"54","author":"Ryan","year":"2005","journal-title":"Diabetes."},{"issue":"8","key":"10.1111\/ajt.15643_bib4","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1111\/j.1600-6143.2005.00957.x","article-title":"Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosupression: miami experience","volume":"5","author":"Froud","year":"2005","journal-title":"Am J Transplant."},{"key":"10.1111\/ajt.15643_bib5","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3389\/fmed.2018.00202","article-title":"The future of islet transplantation is now","volume":"5","author":"Bottino","year":"2018","journal-title":"Front Med."},{"issue":"2","key":"10.1111\/ajt.15643_bib6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1517\/03009734000000059","article-title":"Isolated human islets trigger an instant blood mediated inflammatory reaction: implications for intraportal islet transplantation as a treatment for patients with type 1 diabetes","volume":"105","author":"Bennet","year":"2000","journal-title":"Ups J Med Sci."},{"issue":"3","key":"10.1111\/ajt.15643_bib7","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/01.tp.0000275401.80187.1e","article-title":"Interference with tissue factor prolongs intrahepatic isllograft survival in a nonhuman primate marginal mass model","volume":"84","author":"Berman","year":"2007","journal-title":"Transplantation."},{"issue":"6","key":"10.1111\/ajt.15643_bib8","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.2337\/diabetes.54.6.1755","article-title":"Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation","volume":"54","author":"Johansson","year":"2005","journal-title":"Diabetes."},{"issue":"9350","key":"10.1111\/ajt.15643_bib9","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/S0140-6736(02)12020-4","article-title":"Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation","volume":"360","author":"Moberg","year":"2002","journal-title":"Lancet."},{"issue":"7","key":"10.1111\/ajt.15643_bib10","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S2213-8587(18)30078-0","article-title":"Islet transplantation versus insulin therapy in patients with type 1 diabetes with severe hypoglycaemia or poorly controlled glycaemia after kidney transplantation (TRIMECO): a multicentre, randomised controlled trial","volume":"6","author":"Lablanche","year":"2018","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"4","key":"10.1111\/ajt.15643_bib11","doi-asserted-by":"crossref","first-page":"970","DOI":"10.2337\/db16-1036","article-title":"\u03b1-1 Antitrypsin enhances islet engraftment by suppression of instant blood-mediated inflammatory reaction","volume":"66","author":"Wang","year":"2017","journal-title":"Diabetes."},{"key":"10.1111\/ajt.15643_bib12","doi-asserted-by":"crossref","first-page":"451035","DOI":"10.1155\/2014\/451035","article-title":"Inflammatory response in islet transplantation","volume":"2014","author":"Kanak","year":"2014","journal-title":"Int J Endocrinol."},{"issue":"2","key":"10.1111\/ajt.15643_bib13","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1600-6143.2011.03796.x","article-title":"Anakinra potentiates the protective effects of etanercept in transplantation of marginal mass human islets in immunodeficient Mice","volume":"12","author":"McCall","year":"2012","journal-title":"Am J Transplant."},{"issue":"2","key":"10.1111\/ajt.15643_bib14","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/TP.0000000000001925","article-title":"Anti-inflammatory strategies in intrahepatic islet transplantation: a comparative study in preclinical models","volume":"102","author":"Citro","year":"2018","journal-title":"Transplantation."},{"issue":"7","key":"10.1111\/ajt.15643_bib15","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1001\/jama.293.7.830","article-title":"Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes","volume":"293","author":"Hering","year":"2005","journal-title":"JAMA."},{"issue":"12","key":"10.1111\/ajt.15643_bib16","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1097\/TP.0b013e31818fe448","article-title":"Long-term insulin independence and improvement in insulin secretion after supplemental islet infusion under exenatide and etanercept","volume":"86","author":"Faradji","year":"2008","journal-title":"Transplantation."},{"issue":"6","key":"10.1111\/ajt.15643_bib17","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1111\/j.1600-6143.2008.02234.x","article-title":"Islet transplantation for brittle type 1 diabetes: the UIC protocol","volume":"8","author":"Gangemi","year":"2008","journal-title":"Am J Transplant."},{"issue":"6","key":"10.1111\/ajt.15643_bib18","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1111\/j.1600-6143.2011.03977.x","article-title":"Potent induction immunotherapy promotes long-term insulin independence after islet transplantation in type 1 diabetes","volume":"12","author":"Bellin","year":"2012","journal-title":"Am J Transplant."},{"issue":"10","key":"10.1111\/ajt.15643_bib19","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.3727\/096368910X564058","article-title":"Improving efficacy of clinical islet transplantation with iodixanol-based islet purification, thymoglobulin induction, and blockage of IL-1b; and TNF-a","volume":"20","author":"Matsumoto","year":"2011","journal-title":"Cell Transplant."},{"issue":"5","key":"10.1111\/ajt.15643_bib20","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/TP.0b013e3181b230ac","article-title":"Surface modification of islets with PEG-lipid for improvement of graft survival in intraportal transplantation","volume":"88","author":"Teramura","year":"2009","journal-title":"Transplantation."},{"issue":"34","key":"10.1111\/ajt.15643_bib21","doi-asserted-by":"crossref","first-page":"5828","DOI":"10.1016\/j.biomaterials.2006.07.039","article-title":"Encapsulation of islets with ultra-thin polyion complex membrane through poly(ethylene glycol)-phospholipids anchored to cell membrane","volume":"27","author":"Miura","year":"2006","journal-title":"Biomaterials."},{"issue":"51","key":"10.1111\/ajt.15643_bib22","doi-asserted-by":"crossref","first-page":"18228","DOI":"10.1021\/ja908887v","article-title":"Noncovalent cell surface engineering with cationic graft copolymers","volume":"131","author":"Wilson","year":"2009","journal-title":"J Am Chem Soc."},{"key":"10.1111\/ajt.15643_bib23","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.actbio.2016.11.060","article-title":"The impact of cell surface PEGylation and short-course immunotherapy on islet graft survival in an allogeneic murine model","volume":"49","author":"Giraldo","year":"2017","journal-title":"Acta Biomater."},{"issue":"11","key":"10.1111\/ajt.15643_bib24","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0142-9612(99)00283-5","article-title":"Treatment of rat pancreatic islets with reactive PEG","volume":"21","author":"Panza","year":"2000","journal-title":"Biomaterials."},{"issue":"3","key":"10.1111\/ajt.15643_bib25","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/jbm.10246","article-title":"Optimization of monomethoxy-polyethylene glycol grafting on the pancreatic islet capsules","volume":"62","author":"Lee","year":"2002","journal-title":"J Biomed Mater Res."},{"issue":"7","key":"10.1111\/ajt.15643_bib26","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1016\/j.actbio.2010.01.031","article-title":"Immunocamouflage: The biophysical basis of immunoprotection by grafted methoxypoly(ethylene glycol) (mPEG)","volume":"6","author":"Le","year":"2010","journal-title":"Acta Biomater."},{"issue":"8","key":"10.1111\/ajt.15643_bib27","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1089\/ten.2006.0009","article-title":"Highly poly(ethylene) glycolylated islets improve long-term islet allograft survival without immunosuppressive medication","volume":"13","author":"Lee","year":"2007","journal-title":"Tissue Eng."},{"issue":"12","key":"10.1111\/ajt.15643_bib28","doi-asserted-by":"crossref","first-page":"833","DOI":"10.2165\/00063030-200115120-00005","article-title":"Current and future applications of immunological attenuation via pegylation of cells and tissue","volume":"15","author":"Chen","year":"2001","journal-title":"BioDrugs."},{"issue":"14","key":"10.1111\/ajt.15643_bib29","doi-asserted-by":"crossref","first-page":"7566","DOI":"10.1073\/pnas.94.14.7566","article-title":"Chemical camouflage of antigenic determinants: stealth erythrocytes","volume":"94","author":"Scott","year":"1997","journal-title":"Proc Natl Acad Sci USA."},{"issue":"10\u201311","key":"10.1111\/ajt.15643_bib30","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3727\/096368908787236657","article-title":"Cell surface modification by activated polyethylene glycol prevents allosensitization after islet transplantation","volume":"17","author":"Wee","year":"2008","journal-title":"Cell Transplant."},{"issue":"2","key":"10.1111\/ajt.15643_bib31","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.transproceed.2012.02.028","article-title":"Synergistic effect of surface modification with poly(ethylene glycol) and immunosuppressants on repetitive pancreatic islet transplantation into antecedently sensitized rat","volume":"45","author":"Jeong","year":"2013","journal-title":"Transplant Proc."},{"issue":"11","key":"10.1111\/ajt.15643_bib32","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/j.biomaterials.2006.12.015","article-title":"Functional and histological evaluation of transplanted pancreatic islets immunoprotected by PEGylation and cyclosporine for 1 year","volume":"28","author":"Lee","year":"2007","journal-title":"Biomaterials."},{"issue":"12","key":"10.1111\/ajt.15643_bib33","doi-asserted-by":"crossref","first-page":"e50265","DOI":"10.1371\/journal.pone.0050265","article-title":"Immuno-isolation of pancreatic isllografts using pegylated nanotherapy leads to long-term normoglycemia in full MHC mismatch recipient mice","volume":"7","author":"Dong","year":"2012","journal-title":"PLoS ONE ONE."},{"issue":"2","key":"10.1111\/ajt.15643_bib34","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jconrel.2005.10.023","article-title":"A combination therapy of PEGylation and immunosuppressive agent for successful islet transplantation","volume":"110","author":"Lee","year":"2006","journal-title":"J Control Release."},{"issue":"8","key":"10.1111\/ajt.15643_bib35","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1111\/j.1600-6143.2006.01414.x","article-title":"Minimization of immunosuppressive therapy after islet transplantation: combined action of heme oxygenase-1 and PEGylation to islet","volume":"6","author":"Lee","year":"2006","journal-title":"Am J Transplant."},{"issue":"8","key":"10.1111\/ajt.15643_bib36","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/j.biomaterials.2012.11.028","article-title":"The effects of 8-arm-PEG-catechol\/heparin shielding system and immunosuppressive drug, FK506 on the survival of intraportally allotransplanted islets","volume":"34","author":"Im","year":"2013","journal-title":"Biomaterials."},{"key":"10.1111\/ajt.15643_bib37","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.biomaterials.2016.01.039","article-title":"Combination strategy of multi-layered surface camouflage using hyperbranched polyethylene glycol and immunosuppressive drugs for the prevention of immune reactions against transplanted porcine islets","volume":"84","author":"Haque","year":"2016","journal-title":"Biomaterials."},{"issue":"31","key":"10.1111\/ajt.15643_bib38","doi-asserted-by":"crossref","first-page":"7961","DOI":"10.1016\/j.biomaterials.2011.06.068","article-title":"Surface camouflage of pancreatic islets using 6-arm-PEG-catechol in combined therapy with tacrolimus and anti-CD154 monoclonal antibody for xenotransplantation","volume":"32","author":"Jeong","year":"2011","journal-title":"Biomaterials."},{"key":"10.1111\/ajt.15643_bib39","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.biomaterials.2018.04.028","article-title":"Polymeric nano-shielded islets with heparin-polyethylene glycol in a non-human primate model","volume":"171","author":"Park","year":"2018","journal-title":"Biomaterials."},{"issue":"14","key":"10.1111\/ajt.15643_bib40","doi-asserted-by":"crossref","first-page":"8132","DOI":"10.1073\/pnas.96.14.8132","article-title":"Long-term survival and function of intrahepatic isllografts in rhesus monkeys treated with humanized anti-CD154","volume":"96","author":"Kenyon","year":"1999","journal-title":"Proc Natl Acad Sci USA."},{"issue":"6","key":"10.1111\/ajt.15643_bib41","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1021\/bc7002814","article-title":"Surface re-engineering of pancreatic islets with recombinant azido-thrombomodulin","volume":"18","author":"Stabler","year":"2007","journal-title":"Bioconjug Chem."},{"issue":"10","key":"10.1111\/ajt.15643_bib42","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.3727\/000000007783472408","article-title":"Automated, high-throughput assays for evaluation of human pancreatic islet function","volume":"16","author":"Cabrera","year":"2007","journal-title":"Cell Transplant."},{"issue":"1","key":"10.1111\/ajt.15643_bib43","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/bit.26442","article-title":"Glucose-stimulated insulin release: parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets","volume":"115","author":"Buchwald","year":"2018","journal-title":"Biotechnol Bioeng."},{"issue":"11","key":"10.1111\/ajt.15643_bib44","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/j.biomaterials.2006.12.015","article-title":"Functional and histological evaluation of transplanted pancreatic islets immunoprotected by PEGylation and cyclosporine for 1 year","volume":"28","author":"Yun Lee","year":"2007","journal-title":"Biomaterials."},{"issue":"2","key":"10.1111\/ajt.15643_bib45","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2337\/diabetes.51.2.265","article-title":"Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates","volume":"51","author":"Adams","year":"2002","journal-title":"Diabetes."},{"issue":"3","key":"10.1111\/ajt.15643_bib46","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nrd1033","article-title":"Effect of pegylation on pharmaceuticals","volume":"2","author":"Harris","year":"2003","journal-title":"Nat Rev Drug Discov."},{"key":"10.1111\/ajt.15643_bib47","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0305-7372(02)80004-4","article-title":"Pegylation: engineering improved pharmaceuticals for enhanced therapy","volume":"28","author":"Molineux","year":"2002","journal-title":"Cancer Treat Rev."},{"issue":"26","key":"10.1111\/ajt.15643_bib48","doi-asserted-by":"crossref","first-page":"12327","DOI":"10.1021\/la051726h","article-title":"Influence of PEG architecture on protein adsorption and conformation","volume":"21","author":"Michel","year":"2005","journal-title":"Langmuir."},{"issue":"5","key":"10.1111\/ajt.15643_bib49","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1021\/la702310t","article-title":"Protein-resistant poly(ethylene oxide)-grafted surfaces: chain density-dependent multiple mechanisms of action","volume":"24","author":"Unsworth","year":"2008","journal-title":"Langmuir."},{"issue":"1","key":"10.1111\/ajt.15643_bib50","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0168-3659(01)00277-2","article-title":"Improvements in protein PEGylation: pegylated interferons for treatment of hepatitis C","volume":"72","author":"Kozlowski","year":"2001","journal-title":"J Control Release."},{"key":"10.1111\/ajt.15643_bib51","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jconrel.2017.04.021","article-title":"Xenotransplantation of layer-by-layer encapsulated non-human primate islets with a specified immunosuppressive drug protocol","volume":"258","author":"Haque","year":"2017","journal-title":"J Control Release."},{"issue":"6","key":"10.1111\/ajt.15643_bib52","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.2337\/diabetes.51.6.1779","article-title":"Inhibition of thrombin abrogates the instant blood-mediated inflammatory reaction triggered by isolated human islets","volume":"51","author":"\u00d6zmen","year":"2002","journal-title":"Diabetes."},{"issue":"26","key":"10.1111\/ajt.15643_bib53","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1056\/NEJMc070201","article-title":"Visualization of early engraftment in clinical islet transplantation by positron-emission tomography","volume":"356","author":"Eich","year":"2007","journal-title":"N Engl J Med."},{"issue":"10","key":"10.1111\/ajt.15643_bib54","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.2337\/diabetes.48.10.1907","article-title":"Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation?","volume":"48","author":"Bennet","year":"1999","journal-title":"Diabetes."},{"issue":"5","key":"10.1111\/ajt.15643_bib55","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s11892-013-0401-0","article-title":"Anti-inflammatory strategies to enhance islet engraftment and survival","volume":"13","author":"Citro","year":"2013","journal-title":"Curr Diab Rep."},{"issue":"1","key":"10.1111\/ajt.15643_bib56","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3109\/2000-1967-181","article-title":"The role of the innate immunity in islet transplantation","volume":"110","author":"Moberg","year":"2005","journal-title":"Ups J Med Sci."},{"issue":"7","key":"10.1111\/ajt.15643_bib57","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.4049\/jimmunol.177.7.4794","article-title":"A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways","volume":"177","author":"Ritis","year":"2006","journal-title":"J Immunol."},{"issue":"5","key":"10.1111\/ajt.15643_bib58","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1177\/193229680800200502","article-title":"Thrombosis and inflammation in intraportal islet transplantation: a review of pathophysiology and emerging therapeutics","volume":"2","author":"Wilson","year":"2008","journal-title":"J Diabetes Sci Technol."},{"issue":"10","key":"10.1111\/ajt.15643_bib59","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.3727\/096368910X564058","article-title":"Improving efficacy of clinical islet transplantation with iodixanol-based islet purification, thymoglobulin induction, and blockage of IL-1\u03b2 and TNF-\u03b1","volume":"20","author":"Matsumoto","year":"2011","journal-title":"Cell Transplant."},{"issue":"5","key":"10.1111\/ajt.15643_bib60","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/09546630410017275","article-title":"A comprehensive review and evaluation of the side effects of the tumor necrosis factor alpha blockers etanercept, infliximab and adalimumab","volume":"15","author":"Scheinfeld","year":"2004","journal-title":"J Dermatol Treat."},{"issue":"8","key":"10.1111\/ajt.15643_bib61","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.2337\/db13-0106","article-title":"Evidence for rapamycin toxicity in pancreatic \u03b2-cells and a review of the underlying molecular mechanisms","volume":"62","author":"Barlow","year":"2013","journal-title":"Diabetes."},{"issue":"11","key":"10.1111\/ajt.15643_bib62","first-page":"2406","article-title":"Long-term metabolic and immunological follow-up of nonimmunosuppressed patients with type 1 diabetes treated with microencapsulated islet allografts","volume":"34","author":"Basta","year":"2011","journal-title":"Diabetes."},{"key":"10.1111\/ajt.15643_bib63","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ebiom.2016.08.034","article-title":"Clinical benefit of islet xenotransplantation for the treatment of type 1 diabetes","volume":"12","author":"Matsumoto","year":"2016","journal-title":"EBioMedicine."},{"issue":"7","key":"10.1111\/ajt.15643_bib64","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1007\/s00125-013-2906-0","article-title":"Sustained function of alginate-encapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient","volume":"56","author":"Jacobs-Tulleneers-Thevissen","year":"2013","journal-title":"Diabetologia."},{"key":"10.1111\/ajt.15643_bib65","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.biomaterials.2017.05.038","article-title":"MRI-sensitive contrast agent with anticoagulant activity for surface camouflage of transplanted pancreatic islets","volume":"138","author":"Hwang","year":"2017","journal-title":"Biomaterials."},{"issue":"53","key":"10.1111\/ajt.15643_bib66","doi-asserted-by":"crossref","first-page":"10652","DOI":"10.1039\/C5CC02570B","article-title":"Assembly of bioactive multilayered nanocoatings on pancreatic islet cells: incorporation of alpha1-antitrypsin into the coatings","volume":"51","author":"Zhi","year":"2015","journal-title":"Chem Commun."},{"issue":"7","key":"10.1111\/ajt.15643_bib67","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1021\/bc800064t","article-title":"Islets surface modification prevents blood-mediated inflammatory responses","volume":"19","author":"Teramura","year":"2008","journal-title":"Bioconjug Chem."},{"issue":"21","key":"10.1111\/ajt.15643_bib68","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.1016\/j.biomaterials.2013.03.041","article-title":"Inhibition of instant blood-mediated inflammatory responses by co-immobilization of sCR1 and heparin on islets","volume":"34","author":"Luan","year":"2013","journal-title":"Biomaterials."},{"key":"10.1111\/ajt.15643_bib69","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.msec.2017.03.295","article-title":"Pancreatic islet surface bioengineering with a heparin-incorporated starPEG nanofilm","volume":"78","author":"Lou","year":"2017","journal-title":"Mater Sci Eng C."},{"issue":"11","key":"10.1111\/ajt.15643_bib70","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s00251-010-0481-9","article-title":"Characterization of Mauritian cynomolgus macaque major histocompatibility complex class I haplotypes by high-resolution pyrosequencing","volume":"62","author":"Budde","year":"2010","journal-title":"Immunogenetics."},{"issue":"2","key":"10.1111\/ajt.15643_bib71","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/ilar\/ilt036","article-title":"Haplessly hoping: macaque major histocompatibility complex made easy","volume":"54","author":"Wiseman","year":"2013","journal-title":"ILAR J."}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.15643","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajt.15643","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522222333?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522222333?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.15643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:26:27Z","timestamp":1761629187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522222333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S1600613522222333"],"URL":"https:\/\/doi.org\/10.1111\/ajt.15643","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transplantation of PEGylated islets enhances therapeutic efficacy in a diabetic nonhuman primate model","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.15643","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}